Neurulation and Neural Tube Defects

Donkelaar, Hans J. ten; Bekker, Mireille N.; Renier, W.O.; Hori, Akira; Shiota, Kohei

doi:10.1007/978-3-642-54687-7_4

Cited by 4 publications

(1 citation statement)

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“…The neural plate and the membranous ring are usually surrounded by normal skin. With time, the membranous ring and the neural plate may become partially epithelialized by cells that grow medially from the skin margins to cover the midline defect [30]. Since most of the patients present late it is not surprising that some patients with myelomeningocele present with infected placode (Fig.…”

Section: Discussionmentioning

confidence: 99%

Clinical profile of cranial and spinal dysraphism in Lagos, Nigeria

et al. 2015

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Cranial and spinal dysraphisms have different incidence in different parts of the world depending on the geographic region, ethnicity, socioeconomic status of the parents, maternal age and parity. Our aim was to determine the current state of neural tube defects in our environment where there is no policy of food supplementation with folic acid. A prospective study of 47 consecutive patients (and their parents) with neural tube defects who presented at the pediatric and neurosurgical unit of Lagos State University Teaching Hospital, Ikeja, Lagos between August 2006 and July 2007 were studied. Most patients were males. The male to female ratio for myelomeningocoele and encephalocele was 2:1 and 1:1.5, respectively. The most common dysraphism was open spinal dysraphism (77%) and this occurred usually at the lumbosacral region (67%). None of the infants was offspring of consanguineous marriage. Most patients were second born. Presentation of patients to the hospital was after 48 hours of delivery in majority of cases. The average maternal age at conception was 27 years (18?37 years). There was no history of preconception use of folic acid in all the mothers of the patients. There is a need to consider an aggressive approach to periconceptional folic acid supplementation for our women and early referral of patients with cranial and spinal dysraphisms. Policy to encourage fortification of a staple food with folic acid is urgently needed.

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Section: Discussionmentioning

confidence: 99%