Neusilin based liquisolid compacts of albendazole: Design, development, characterization and in vitro anthelmintic activity

Abstract

The present investigation deals with enhancement of dissolution rate of high dose drug albendazole (ABZ) using liquisolid compacts. Study of precompression characteristics, influence of excipients on drug release characteristics and to compare drug release profile of the formulated liquisolid compacts with the directly compressible laboratory made formulation. Liquisolid compacts were prepared by using three by twofactorial designs and evaluated for differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), in vitro nthelmintic, in vitro antifungal study and in vitro dissolution study. There was improvement in the dissolution rate and solubility was attributed to decreased melting point and crystallinity of albendazole. In vitro anthelmintic and antifungal activities of neusilin based liquisolid compacts were more than pure albendazole. The drug content of liquisolid compacts was not affected when stored at room temperature for a period of 3 months. This study also provided evidence that it is possible to load high amounts of drug into liquisolid compacts due to the neusilin allows higher liquid adsorption capacities. Neusilin based technique is useful for the preparation of liquisolid compacts of high dose drug like albendazole with enhancement in dissolution rate

Tablet Formulation of 2-((3-(Chloromethyl)benzoyl)oxy)benzoic Acid by Linear and Quadratic Models

“…The 3CH 2 Cl tablet formula used excipients Ne, SLS, CS, MCC, and SDL. Ne was used to prevent the coagulation of 3CH 2 Cl. − The SLS–CS combination improved the flowability of 3CH 2 Cl. SLS can accelerate the tablet hydration through disintegration or dissolution media.…”

Exploration of Neusilin® US2 as an Acceptable Filler in HPMC Matrix Systems—Comparison of Pharmacopoeial and Dynamic Biorelevant Dissolution Study

“…In the silicate family, Neusilin ® is an entirely synthetic MAS, insoluble in water, and available in 11 different grades as an amorphous white powder or granules with the empirical formula Al 2 O 3 •MgO•1.7SiO 2 •xH 2 O. It is prepared using the spray drying process, resulting in an extensive specific surface area (100-300 m 2 /g) [12], high absorption capacity (up to 3.4 mL/g), high porosity [13], and good flow [14] and compression properties [15,16]. In an aqueous medium, it does not form a gel [12].…”

Stress-Dependent Particle Interactions of Magnesium Aluminometasilicates as Their Performance Factor in Powder Flow and Compaction Applications

“…The high porosity and large specific surface area give Neusilin ® significant adsorption capacity [ 33 ]. With respect to this, Neusilin ® is an excellent carrier for solid drug delivery systems and hot-melt extrusion [ 34 , 35 , 36 , 37 , 38 , 39 ]. Moreover, it is known for its ability to improve powder flow properties [ 33 , 40 , 41 , 42 ].…”