Neutral 1,3‐Diindolylureas for Nerve Agent Remediation

Abstract

Efficient neutralization of nerve‐agent simulants by 1,3‐diindolylureas in a neutral medium was investigated (see scheme; DCP=diethylchlorophosphate, DCNP=diethylcyanophosphonate). The rate of hydrolysis of the simulants was found to increase by as much as 45 % in the presence of these compounds. A mechanism based on the simulant complexation was established.

Supramolecular chemistry and chemical warfare agents: from fundamentals of recognition to catalysis and sensing

“…18) and the nerve agent GD (foreground) in a solvent free environment. 35 Complexation results in polarisation of the DCNP PQO bond, resulting in an increased electrophilic character of the phosphorus centre and increased susceptibility to hydrolysis. Reproduced from ref.…”

Supramolecular Detection of a Nerve Agent Simulant by Fluorescent Zn–Salen Oligomer Receptors

“…To date, only a few examples of supramolecular hosts for CWA simulants have been reported in the literature [14,15,16,17,18,19,20,21,22,23,24]. They exploit several non-covalent interactions for the recognition of the guest, such as inclusion within the hydrophobic macrocyclic cavity [14,15,16,17] or hydrogen bond-dependent gel formation [18,19,20,21,22,23,24,25].…”

“…They exploit several non-covalent interactions for the recognition of the guest, such as inclusion within the hydrophobic macrocyclic cavity [14,15,16,17] or hydrogen bond-dependent gel formation [18,19,20,21,22,23,24,25]. …”

Nerve Gas Simulant Sensing by a Uranyl–Salen Monolayer Covalently Anchored on Quartz Substrates

“…[47] Acidic polymers for surface acoustic wave sensorsa nd inverse gas chromatography of DMMP were recently developed. [51][52][53][54][55][56][57][58][59][60][61][62] In recent years, Badjić and co-workers reported on the supramolecular recognitiono fO Pb yu sing am olecular basket as ah ydrophobic host to obtain efficient recognitiono f aromatic OP. Examples of the noncovalent recognition of CWAs imulants include some gels, as well as cyclodextrin and cavitand hosts that grant hydrophobic effects and hydrogen bonds to the guest.…”