Neutral pH and low–glucose degradation product dialysis fluids induce major early alterations of the peritoneal membrane in children on peritoneal dialysis

Comparison of Longitudinal Membrane Function in Peritoneal Dialysis Patients According to Dialysis Fluid Biocompatibility

“…Besides, some studies on peritoneal histology have been published, two of which contained a cross-sectional comparison between adult patients treated with CON or with BIO (19,20). One study in children focused on effects of peritoneal dialysis with biocompatible solutions on morphology and partly on peritoneal solute transport (21).…”

A randomized controlled trial of alanyl-glutamine supplementation in peritoneal dialysis fluid to assess impact on biomarkers of peritoneal health

“…P eritoneal dialysis (PD) is a cost-effective and safe dialysis modality in end-stage renal disease patients. However, currently available peritoneal dialysis fluids (PDFs) show limited biocompatibility, [1][2][3][4] resulting in functional and/or structural injuries of mesothelial cells and peritoneal leukocytes. 2,[5][6][7] Previous studies have accordingly demonstrated that the majority of PD patients experience a complicated course, sometimes necessitating a change to another type of renal replacement therapy.…”

Welche PD-Lösung bei Peritonealdialyse?

“…In Diskussion ist, ob dies über den Volumenstatus allein erklärt werden kann, da in den Interventionsstudien häufig ein kurzfristiger Rückgang der UF gesehen wurde [18][19][20]. Neuere Arbeiten bei kindlichen PD-Patienten zeigen allerdings, dass die Veränderungen am Peritoneum bei biokompatiblen PD-Lösungen sogar verstärkt feststellbar sind, insbesondere die Neoangiogenese [21].…”