Neutralisation titres against SARS-CoV-2 are sustained 6 months after onset of symptoms in individuals with mild COVID-19

Immunological response after mild COVID-19: How long will it last?

“…Baseline blood tests were not performed homogeneously, but with a relatively wide range after symptom onset (median of 49 days, range 29À86), whereas 6 month tests were consistently drawn at a median of 186 days (range 182À192). The increasing pattern of neutralizing antibodies in 3 patients was likely due to a re-exposure [1].…”

“…This manuscript contributes to add a missing tile to the mosaic. The first key-message of this manuscript is that all subjects demonstrated neutralizing activity at baseline as well as 6 months after symptom onset [1].…”

“…There was an absence of significant differences between baseline samples drawn in the second or third month and the corresponding 6 month test. The significantly lower neutralization titres in samples collected at between 2 and 3 months after the symptom onset suggests that the peak occurs at one month [1].…”

“…A third message comes from the observed trend between the neutralization titres at 6 months and the number of symptoms reported, but not the duration of symptoms. Patients in this cohorts reported a median of 5 symptoms (interquartile range -IQR: 4À8), with the most common being fatigue (73%), fever (71%), and headache (67%), elapsing a median of 14 days (IQR: 8À16) [1].…”

“…Participant were 18 years or older, diagnosed between March and July 2020 with mild COVID-19, confirmed by PCR assessment in all but 3 cases, who were assessed by serology. Findings were compared with 41 healthy controls [1].…”