2023
DOI: 10.1038/s41598-023-44484-x
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Neutralization against Omicron sublineages (BA.2/BA.5/BQ.1.1/XBB/XBB.1.5) in bivalent BNT162b2-vaccinated HCWs with or without risk factors, or following BT infection with Omicron

Masayuki Amano,
Sachiko Otsu,
Yukari Uemura
et al.

Abstract: SARS-CoV-2-BA.4/5-adapted-bivalent-BNT162b2-vaccine (bvBNT), developed in response to the recent emergence of immune-evasive Omicron-variants, has been given to individuals who completed at least 2-doses of the monovalent-BNT162b2-vaccine (mvBNT). In the present cohort study, we evaluated neutralization-titers (NT50s) against Wuhan-strain (SCoV2Wuhan) and Omicron-sublineages including BA.2/BA.5/BQ.1.1/XBB/XBB.1.5, and vaccine-elicited S1-binding-IgG in sera from participants-vaccinated with 5th-bvBNT following… Show more

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Cited by 10 publications
(2 citation statements)
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“…We confirmed the role of hybrid immunity, defined as the history of SARS‐CoV‐2 natural infection in vaccinated people, in achieving higher levels of nAbs against all the tested variants. Indeed, in line with previous reports, nAbs titers were constantly higher in HI than in nHI at each time point and against all the variants tested 23–26 …”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…We confirmed the role of hybrid immunity, defined as the history of SARS‐CoV‐2 natural infection in vaccinated people, in achieving higher levels of nAbs against all the tested variants. Indeed, in line with previous reports, nAbs titers were constantly higher in HI than in nHI at each time point and against all the variants tested 23–26 …”
Section: Discussionsupporting
confidence: 92%
“…Indeed, in line with previous reports, nAbs titers were constantly higher in HI than in nHI at each time point and against all the variants tested. [23][24][25][26] When assessing the ability to neutralize the currently prevalent changes were observed neither 3 months or 6 months after the vaccine booster nor did we demonstrate a difference due to hybrid immunity. We did not investigate the role and dynamics of T cell response directed against XBB sublineages, nevertheless, the impact of variants associated mutations on T cell responses seems to be limited, 28,29 by meaning that the preservation of T cells response directed toward more conserved targets in vaccine composition may be considered as a possible tool to increase vaccine effectiveness against future variants.…”
Section: Study Populationmentioning
confidence: 56%