Neutralization potential of Viper russelli russelli (Russell’s viper) venom by ethanol leaf extract of Acalypha indica

Shirwaikar, Annie; Rajendran, Kumar; Bodla, Ramgopal; Kumar, Chandan

doi:10.1016/j.jep.2004.05.010

Cited by 47 publications

(30 citation statements)

References 12 publications

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“…Studies focused in some species to investigate and isolate the bioactive compounds from different part of the plant. The extracts from different parts of the plants belonging to the Asteraceae family showed an antihemorrhagic, antiproteolytic, anti-phospholipase (Abid et al, 2007;Mariane et al, 2011), antilethality (Shirwaikar et al, 2004;Pithayanukul et al, 2009), antiedema, (Ticli et al, 2005;Nishijima et al, 2009), antinecrosis (Bjarnason et al, 1978;Houghton et al, 1992;Chareanchai et al, 2009;Soares et al, 2005), anti-myotoxicity (Theakston and Reid, 1992;Bjarnason and Fox, 1994;Soares et al, 2004) and anticoagulant effect (Bjarnason and Tu, 1978;Bjarnason and Fox, 1994). Our results have some similarities with those research investigations.…”

Section: Discussionsupporting

confidence: 86%

Anti-hemolytic and Anti-cytotoxic Effect of Two Artemisia Species (A. campestris and A. herba-alba) Essential Oil against Snake Venom

Jaouadi

Abdelkafi-Koubaa

Riabi-Ayari

et al. 2016

IJAB

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To cite this paper: Jaouadi, I., Z. Abdelkafi-Koubaa, S. Riabi-Ayari, I. Hassen, M.T. Yakoubi, M. El-Ayeb, M. El-Gazzah and N. Marrakchi, 2016. Antihemolytic and anti-cytotoxic effect of two Artemisia species (A. campestris and A. herba-alba) essential oil against snake venom. AbstractIn this study, we verify the possible activity of Artemisia herba-alba and A. campestris (Asteraceae) essential oil against the snake venoms. The leaves of A. campestris has been used in the folk medicine against snake moisture. The aerial part extracts of both plants have been tested for their action against snake venom. Interaction of A. campestris (E1) and A. herba alba (E2) essential oils with proteins extracted from snake venom has been tested. Lethality in mice, inflammation and cytotoxicity induced by Cerastes cerastes venoms were significantly inhibited by the mixture of different amounts of E1 and E2 and the venom. However, both extracts showed neutralization of the venoms hemolytic activity which is more important with E2. Chemical characterization of E1 and E2 revealed there is an important amount of polyphenols and tannins which are known by their bio-active effect. The result could lead as to think that these components have an action by inhibiting the toxicity of snake venoms in vitro. We can conclude therefore that the use of the essential oil from the two Artemisia species have a curative effect on the snake venom. These results confirmed the traditional use of A. campestris and we discovered a similar effect of A. herba-alba. No data have been reported till now about the essential oil curative effect of both species.

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Section: Discussionsupporting

confidence: 86%

Anti-hemolytic and Anti-cytotoxic Effect of Two Artemisia Species (A. campestris and A. herba-alba) Essential Oil against Snake Venom

Jaouadi

Abdelkafi-Koubaa

Riabi-Ayari

et al. 2016

IJAB

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“…Phenol compounds including: phenolic acids, flavones and flavonols have been isolated in others species of genus Acalypha and are the main inhibitory substances used as the antibacterial, antifungal and antioxidant agents (Alade and Irobi, 1993;Cowan, 1999;Ejechi and Souzey, 1999;Shirwaikar et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…Acalypha is the fourth largest genus in the Euphorbiaceae with about 450 species (Webster, 1994). Several species of the genus Acalypha has been studied and it has been demonstrated that they present antioxidant, wound healing, post-coital antifertility, neutralization of venom, antibacterial, (Okanla et al, 1990;Shirwaikar et al, 2004; Perez apoptosis, antifungal and antitrypanosomal activities Gutierrez and Vargas, 2006;Marwah et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the antimicrobial activity of Acalypha monostachya Cav. (Euphorbiales: Euphorbiaceae)

Canales¹

2011

Afr. J. Pharm. Pharmacol.

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Acalypha monostachya (Euphorbiaceae) is used by the inhabitants of San Rafael and ZapotitlanSalinas, Puebla, Mexico, to alleviate illnesses of bacterial and fungal origin. We analyzed the antimicrobial activity of A. monostachya and some of its chemical features. The extracts were obtained by percolation. The antibacterial and antifungal activities were examined through the disc-diffusion method. The general toxicity was carried out by using Artemia salina. The quenching of free radicals by extracts was evaluated by the decolouration of a methanol solution of DPPH·. Total phenols were determined by Folin Ciocalteu reagent. Gram-positive and negative bacteria were sensitive to methanol and hexane extracts. The methanol extract had a bactericidal effect on Vibrio cholera Tor (MIC = 1000 µg/mL). The fungi strain most sensitive to this extract was T. mentagrophytes (LC 50 = 430 µg/mL). The methanol extract showed inhibition of DPPH· radical (SC 50 = 3.45 µg/ml), 43.4% of total phenolics and was toxic against A. salina (LC 50 = 4.5 µg/mL). The methanol extract showed a variety of phenolic compounds, while hexane extract showed different fatty acids methyl ester. The bacterial, antifungal, antioxidant activities and a qualitative chemical characterization of A. monostachya's extracts are reported here for the first time.

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“…Other toxic effect of cyanide includes binding to affecting neurotransmitter receptor Nmethyl-daspartate (NMDA) receptor to increase the release of glutamate and elevate the activity of acetylcholinesterase, an enzyme that catalyse the degradation of acetylcholine and also increase the generation of reactive oxygen species [10]. Although antidotes to cyanide poisoning exist, these have limitations and side effects [11]. Therefore, search for highly effective and safe agents across different scenarios of cyanide toxicity is essential.…”

Section: Introductionmentioning

confidence: 99%

Neuromodulatory effect of solvent fractions of Africa eggplant (Solanium dadyphyllum) against KCN-induced mitochondria damage, viz. NADH-succinate dehydrogenase, NADH- cytochrome c reductase, and succinate-cytochrome c reductase

et al. 2018

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Background: In the past few years, there has been a tremendous increase in the number of plant-based health supplements with respect to their safety and efficacy in diseases treatment and prevention. Solanum dasyphyllum, also known as Africa eggplant is ethnomedicinally used as an antivenom, pain reliever and anticonvulsant in various part of Nigeria, however, there is no scientific data to support some of these claims. Methods: This study evaluated the protective effect of solvent fractions of Solanum dasyphyllum, hexane fraction of S. dasyphyllum (HFSD), dichloromethane fraction of S. dasyphyllum (DFSD), ethylacetate fraction of S. dasyphyllum (EAFSD), methanolic fraction of S. dasyphyllum (MFSD) and crude fraction of S. dasyphyllum (CFSD) on cyanideinduced oxidative stress and neurotoxicity in vitro in the cerebral cortex. Neuroprotective activities were evaluated by assaying for markers of oxidative stress, neurotoxicity and electron transport system enzymes via evaluating lipid peroxidation (LPO), protein carbonyl (PC), reduced glutathione (GSH), acetylcholinesterase (AChE), NADH-succinate dehydrogenase (NSD), NADH-cytochrome c reductase (NCR), and succinate-cytochrome c reductase (SCR) in the homogenate of cerebral cortex.

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Neutralization potential of Viper russelli russelli (Russell’s viper) venom by ethanol leaf extract of Acalypha indica

Cited by 47 publications

References 12 publications

Anti-hemolytic and Anti-cytotoxic Effect of Two Artemisia Species (A. campestris and A. herba-alba) Essential Oil against Snake Venom

Anti-hemolytic and Anti-cytotoxic Effect of Two Artemisia Species (A. campestris and A. herba-alba) Essential Oil against Snake Venom

Evaluation of the antimicrobial activity of Acalypha monostachya Cav. (Euphorbiales: Euphorbiaceae)

Neuromodulatory effect of solvent fractions of Africa eggplant (Solanium dadyphyllum) against KCN-induced mitochondria damage, viz. NADH-succinate dehydrogenase, NADH- cytochrome c reductase, and succinate-cytochrome c reductase

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