Neutralizing the free radicals could alleviate the disease severity following an infection by positive strand RNA viruses

Pillai, Agieshkumar Balakrishna; JeanPierre, Aashika Raagavi; Mariappan, Vignesh; Ranganadin, Pajanivel; R, Rao S

doi:10.1007/s12192-022-01269-x

Cited by 13 publications

(9 citation statements)

References 81 publications

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“…DENV and other viruses utilise host factors for the initial access, cell invasion, and replication processes. Additionally, studies have demonstrated that RNA viruses, such as DENV and SARS‐CoV‐2, make use of oxidative stress‐induced ambience when entering the host for genome capping and replication, thus contributing to disease severity 70,71 . Furthermore, +ssRNA can modify gene expression or reprogram the functions of host cell defence mechanisms by co‐opting host factors.…”

Section: Clinical Features Of Dengue Eye Diseasementioning

confidence: 99%

“…Additionally, studies have demonstrated that RNA viruses, such as DENV and SARS-CoV-2, make use of oxidative stress-induced ambience when entering the host for genome capping and replication, thus contributing to disease severity. 70,71 Furthermore, +ssRNA can modify gene expression or reprogram the functions of host cell defence mechanisms by coopting host factors. Therefore, antioxidant therapy may be a potential therapeutic approach for treating RNA viral infections.…”

Section: Maculopathymentioning

confidence: 99%

“…Therefore, antioxidant therapy may be a potential therapeutic approach for treating RNA viral infections. 68,70,71 A study has demonstrated that the envelope (E) protein of SARS-CoV-2 binds to extracellular iron or haem molecules. 72,73 This E-protein-haeme complex produces oxygen and water and then converts them to O 2 − , H 2 O 2 , and hydroxyl radicals, leading to ROS attack, a mechanism similar to that underlying DENV-1 evasion.…”

Section: Maculopathymentioning

confidence: 99%

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Dengue fever ophthalmic manifestations: A review and update

Lucena‐Neto

Falcão

Moraes

et al. 2023

Reviews in Medical Virology

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Dengue fever, the most common arbovirus disease, affects an estimated 390 million people annually. Dengue virus (DENV) is an RNA virus of the Flaviviridae family with four different serotypes. Dengue haemorrhagic fever is the deadliest form of dengue infection and is characterised by thrombocytopaenia, hypotension, and the possibility of multi-system organ failure. The mechanism hypothesised for DENV viral replication is intrinsic antibody-dependent enhancement, which refers to Fcγ receptor-mediated viral amplification. This hypothesis suggests that the internalisation of DENV through the Fcγ receptor inhibits antiviral genes by suppressing type-1 interferon-mediated antiviral responses. DENV NS1 antibodies can promote the release of various inflammatory mediators in the nuclear transcription factor pathway (NF-κB-dependent), including monocyte chemoattractant protein (MCP)-1, interleukin (IL)-6, and IL-8. As a result, MCP-1 increases ICAM-1 expression and facilitates leukocyte transmigration. In addition, anti-DENV NS1 antibodies induce endothelial cell apoptosis via a nitric oxide-regulated pathway. A chain reaction involving pre-existing DENV heterotypic antibodies and innate immune cells causes dysfunction in complement system activity and contributes to the action of autoantibodies and anti-endothelial cells, resulting in endothelial cell dysfunction, bloodretinal barrier breakdown, haemorrhage, and plasma leakage. A spectrum of ocular diseases associated with DENV infection, ranging from haemorrhagic to

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Section: Clinical Features Of Dengue Eye Diseasementioning

confidence: 99%

Section: Maculopathymentioning

confidence: 99%

Section: Maculopathymentioning

confidence: 99%

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Dengue fever ophthalmic manifestations: A review and update

Lucena‐Neto

Falcão

Moraes

et al. 2023

Reviews in Medical Virology

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“…Oxidative stress and hyper-inflammatory response secreted by immune cell/dysregulated immune cells during COVID-19 and DENV infection are considered central factors of disruption of tight junction proteins and endothelial leakage [ 58 – 60 ]. Hence, the anti-oxidant potential of MSC therapy might be an effective strategy in restoring endothelial barrier function.…”

Section: Endothelial Barrier Restoration By Mscs By (I) Inhibiting Mm...mentioning

confidence: 99%

Restoration of vascular endothelial integrity by mesenchymal stromal/stem cells in debilitating virus diseases

et al. 2022

Self Cite

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Endothelial dysfunction is one of the key cornerstone complications of emerging and re-emerging viruses which lead to vascular leakage and a high mortality rate. The mechanism that regulates the origin of endothelial dysregulation is not completely elucidated. Currently, there are no potential pharmacological treatments and curable management for such diseases. In this sense, mesenchymal stromal/stem cells (MSCs) has been emerging to be a promising therapeutic strategy in restoring endothelial barrier function in various lung disease, including ALI and ARDS. The mechanism of the role of MSCs in restoring endothelial integrity among single-strand RNA (ssRNA) viruses that target endothelial cells remains elusive. Thus, we have discussed the therapeutic role of MSCs in restoring vascular integrity by (i) inhibiting the metalloprotease activity thereby preventing the cleavage of tight junction proteins, which are essential for maintaining membrane integrity (ii) possessing antioxidant properties which neutralize the excessive ROS production due to virus infection and its associated hyper host immune response (iii) modulating micro RNAs that regulate the endothelial activation and its integrity by downregulating the inflammatory response during ssRNA infection.

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“…However, when free radicals are produced too much or removed too slowly, they will cause damage to the body. Excessive free radicals lead to a series of diseases such as aging and carcinogenesis ( 13 , 14 ). Free radicals mainly include superoxide anion (O 2 -·), molecular hydrogen peroxide, hydroxyl radical (·OH), and singlet oxygen (O 2 ·).…”

Section: Introductionmentioning

confidence: 99%

Effects of spray drying, freeze drying, and vacuum drying on physicochemical and nutritional properties of protein peptide powder from salted duck egg white

Zhu

et al. 2022

Front. Nutr.

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Salted duck egg white contains many kinds of high quality protein, but it is often discarded as food factory waste because of high salinity and other reasons. The discarded salted duck egg white not only causes a waste of resources, but also causes environmental pollution. Using salted duck egg white as raw material, this study was completed to investigate the effects of three drying methods including freeze drying, vacuum drying, and spray drying on physicochemical and nutritional properties of protein powder from salted duck egg white. The results showed that the solubility, foaming and foaming stability, emulsification and emulsification stability of the protein peptide of salted duck egg white decreased to different degrees after drying. The scavenging rates of freeze-dried samples for superoxide anion, hydroxyl radical, and 1,1-Diphenyl-2-picrylhydrazyl (DPPH·) reached 48.76, 85.03, and 80.17%, respectively. Freeze drying had higher scavenging rates than vacuum drying and spray drying. The results of electron microscopy showed that freeze-drying had the least effect on the structure of protein peptide powder of salted duck egg white. The purpose of this experiment was to provide theoretical guidance and technical support for industrial drying of salted duck egg white protein solution.

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Neutralizing the free radicals could alleviate the disease severity following an infection by positive strand RNA viruses

Cited by 13 publications

References 81 publications

Dengue fever ophthalmic manifestations: A review and update

Dengue fever ophthalmic manifestations: A review and update

Restoration of vascular endothelial integrity by mesenchymal stromal/stem cells in debilitating virus diseases

Effects of spray drying, freeze drying, and vacuum drying on physicochemical and nutritional properties of protein peptide powder from salted duck egg white

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