Neutron applications developing at compact accelerator-driven neutron sources

Kiyanagi, Yoshiaki

doi:10.1007/s43673-021-00022-3

Cited by 18 publications

(8 citation statements)

References 48 publications

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“…And the facility can be also devoted to testing the new-generation boron carrier compounds, which are under development by DawonMedax. As well as the clinical use of BNCT, a neutron-generating system can be used as a testing device to evaluate integrated circuits and discrete semiconductor memory devices using thermal neutron irradiation [52].…”

Section: Discussionmentioning

confidence: 99%

Advances of LINAC-based boron neutron capture therapy in Korea

Bae¹,

Kim²,

Seo³

et al. 2022

AAPPS Bull.

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Boron neutron capture therapy (BNCT) has been attracting interest as a new radiation modality for cancer therapy because it can selectively destroy cancer cells while maintaining the healthy state of surrounding normal cells. Many experimental trials have demonstrated significant BNCT treatment efficacy using neutron beams from research reactors. However, nuclear reactor technology cannot be scaled to sites in hospitals delivering patient treatment. Therefore, compact accelerator-based neutron sources that could be installed in many hospitals are under development or have even been commissioned at many facilities around the world. In Korea, a radio-frequency (RF) linac-based BNCT (A-BNCT) facility is under development by DawonMedax (DM). It provides the highly efficient production of an epithermal neutron beam with an optimized neutron energy spectrum range of 0.1~10 keV. With a 2-mA 10-MeV proton beam from the accelerator, the irradiation port epithermal neutron flux is higher than 1 × 109 n/cm2⋅s. Comprehensive verification and validation of the system have been conducted with the measurement of both proton and neutron beam characteristics. Significant therapeutic effects from BNCT have been confirmed by DM in both in vitro and in vivo non-clinical trials. Further, during exposure to epithermal neutrons, all other unintended radiation is controlled to levels meeting International Atomic Energy Agency (IAEA) recommendations. Recently, the Korean FDA has accepted an investigational new drug (IND) and the first-in-human clinical trial of BNCT is now being prepared. This paper introduces the principles of BNCT and accelerator-based neutron sources for BNCT and reports the recent advances of DM A-BNCT facility which is the main part of this paper.

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Section: Discussionmentioning

confidence: 99%

Advances of LINAC-based boron neutron capture therapy in Korea

Bae¹,

Kim²,

Seo³

et al. 2022

AAPPS Bull.

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“…Fast neutron, uncharged elementary particle with high penetration abilities, [1] is widely used in special nuclear material DOI: 10.1002/adfm.202308263 seeking, [2] nondestructive neutron imaging, [3,4] fast neutron cancer therapy [5,6] and nuclear accident emergency response. [7,8] These applications are predicated on precise detection of neutron energy, neutrons fluence and temporal evolution characteristics.…”

Section: Introductionmentioning

confidence: 99%

2D Perovskite Neutron Scintillators with Nanosecond Time Resolution and Linearity Energy Response

Wan,

Jin,

Gao

et al. 2023

Adv Funct Materials

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Fast and high‐linearity detection of fast neutron is vital for special nuclear material seeking, nuclear accident emergency response, nondestructive neutron imaging, and neutron cancer therapy. Neutron scintillators with fast time resolution and linear energy response are indispensable for precisely acquiring the energy and temporal evolution of fast neutron, but none of the conventional neutron scintillators, whether organic, two‐component or inorganic, have performed well in this regard. To address these challenges, it is urgent to develop novel neutron scintillators. Here, 2D hybrid perovskite single crystals (C4H12N)2PbBr4 (BA2PbBr4) successfully combined with fast response time of 2.66 ns and linear energy response to fast neutrons, γ ray, and α particle, is reported. The rapid response time and linear energy response of 2D hybrid perovskite scintillator originate from intensive states density of lead halide frameworks, which are the key fluorescence emitters under neutron irradiation. This effectively suppresses the ionization quenching effect during the fluorescence process. This work represents a milestone in fast neutron detection, demonstrating a new type of neutron scintillator based on 2D hybrid perovskite single crystals with fast and high‐linearity detection characteristics, having great potential in high precision neutron spectrum measurement and nuclear reaction kinetics monitoring.

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“…The types of neutron sources under construction are mainly include reactor neutron source [ 3 ], accelerator-driven neutron source [ 4 ], and isotopic neutron source [ 5 ]. Recent developments in the field of neutron sources have reignited interest in accelerator-driven neutron sources to supply high-intensity neutron beams to support and develop neutron activities [ 6 ]. Tungsten is mainly used as the target material of accelerator-driven neutron source, especially spallation neutron source [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Water Corrosion of Tungsten Target for Accelerator-Driven Neutron Source

Xie

Sun

et al. 2022

Materials

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The water corrosion of tungsten as a target material can affect the safe operation of accelerator-driven neutron source. This paper reported the corrosion behaviors of tungsten in ultrapure water and tap water for 7, 14, 21, 30 and 60 days. Moreover, ICP-MS, XRD, XPS, SEM-EDS and LSCM were used to analyze the components in solutions, crystalline structures, chemical compositions and surface morphologies. It was found that the dissolution of tungsten, due to corrosion, reached its maximum between 30 days and 60 days in both solutions. The cube-shape substance, CaWO4, was the main corrosion product after tungsten in tap water. The tungsten oxide was changed from WO3 to WO2 during the corrosion of tungsten in ultrapure water. Compared with tungsten in ultrapure water, tungsten in tap water had its surface completely destroyed, with a dense diamond shape. Therefore, based on the analysis from this study, the corrosion mechanisms of tungsten in ultrapure and tap water were revealed.

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Neutron applications developing at compact accelerator-driven neutron sources

Cited by 18 publications

References 48 publications

Advances of LINAC-based boron neutron capture therapy in Korea

Advances of LINAC-based boron neutron capture therapy in Korea

2D Perovskite Neutron Scintillators with Nanosecond Time Resolution and Linearity Energy Response

Water Corrosion of Tungsten Target for Accelerator-Driven Neutron Source

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