Large container radiation imaging systems have a wide range of applications and play an important role in national defense and security inspection areas. In recent years, the development of detectors with photon counting capability will help to improve the detection performance of inspection systems. With individual pulses as the output, the photon-counting system carries energy and time information of radiating particles. The no-load count rate is high in large container radiation imaging systems and the pulse width is narrow under the standard of more than 90% no-pileup rate. Therefore, high-speed voltage comparators are more suitable for obtaining energy information. The chosen time interval to recognize crosstalk signals is 5 to 10ns, which can be achieved by most of the main control chips in data processing systems. The Steel Penetration model is simulated, and the results show that energy and time information have different optimal application conditions, but both can improve the performance of large container radiation imaging systems.