In light of Gödel's undecidability results (incomplete theorems) for math, quantum indeterminism indicates that physics and the Universe may be indeterministic, incomplete, and open in nature, and therefore demand no single unification theory of everything. The Universe is dynamic and so are the underlying physical models and spacetime. As the 4-d spacetime evolves dimension by dimension in the early universe, consistent yet different models emerge one by one with different sets of particles and interactions. A new set of first principles are proposed for building such models with new understanding of supersymmetry, mirror symmetry, and the dynamic phase transition mechanism âĂŞ spontaneous symmetry breaking. Under this framework, we demonstrate that different models with no theory of everything operate in a hierarchical yet consistent way at different phases or scenarios of the Universe. In particular, the arrow of time is naturally explained and the Standard Model of physics is elegantly extended to time zero of the Universe.