Neutron therapy of resistant thyroid gland cancer

Choynzonov, E. L.; Gribova, O. V.; Startseva, Zh. A.; Lisin, V. A.; Novikov, V. A.; Мусабаева, Л. И.

doi:10.1063/1.5001594

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…Schaub et al [83] presented 2 promising observations of Merkel cell carcinoma treated with FNT, noting a potential relationship between high-LET neutron beam irradiation and elevated immune response. Choynzonov et al [49] reported 45 patients with resistant forms of thyroid cancer, 32.8% of them responding to FNT (alone or combined with surgery); the only manifestation of local toxicity was skin epidermitis grade 1 to 3.…”

Section: Clinical Experiencementioning

confidence: 99%

Fast and Furious: Fast Neutron Therapy in Cancer Treatment

Гордон

Гулидов

Fatkhudinov

et al. 2022

International Journal of Particle Therapy

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Fast neutron therapy has been used for decades. In conjunction with recent advances in photonic techniques, fast neutrons are no longer of much oncologic interest, which is not unequivocally positive, given their undoubted therapeutic value. This mini-review recalls the history of medical research on fast neutrons, considers their physical and radiobiological properties alongside their benefits for cancer treatment, and discusses their place in modern radiation oncology.

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Section: Clinical Experiencementioning

confidence: 99%

Fast and Furious: Fast Neutron Therapy in Cancer Treatment

Гордон

Гулидов

Fatkhudinov

et al. 2022

International Journal of Particle Therapy

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“…И в 1999 г. к отечественным исследованиям присоединились специалисты Центра нейтронной терапии в городе Снежинск Челябинской области. Усилиями трех научных институтов было проведено лечение больных злокачественными новообразованиями головы и шеи, молочной железы, саркомами мягких тканей, остеогенными саркомами [4][5][6][7].…”

Section: Introductionunclassified

Combined Treatment of Salivary Gland Cancer Patients with the Use of High-Let Radiation

Gribova,

Startseva,

Choynzonov

et al. 2023

MEDICAL RADIOLOGY AND RADIATION SAFETY

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The purpose: To evaluate the efficiency of combined treatment of patients with salivary gland cancer using neutron therapy. Material and methods: The study included 130 patients with salivary gland cancer who underwent combined treatment with adjuvant neutron or standard photon radiotherapy. Neutron therapy was performed on a cyclotron U-120. The average energy of fast neutrons was 6.3 MeV. Results: There was observed a significant decrease in the frequency of relapses in the group of patients who received a postoperative course of NT compared with the control group (21.1 % vs. 45 %, p<0.05). The five-year overall survival in the study group was 73.8±9.5 %, in the control group ‒ 43.2±9.4% (p<0.05). The value of five-year relapse-free survival in the study group was 65.6±7.5 %, in the control group ‒ 34.8±9.1 % (p<0.05). Erythema of the skin in the irradiation area (grade I) was the most frequent type of local acute radiation reaction and was observed in 60 % of patients in the study group and in 25 % of patients in the control group. The most frequent late complication in both groups of patients was skin atrophy and subcutaneous fibrosis (grade I on the RTOG/EORTC scale). In the study group, this indicator was 34.4 %, in the control group ‒ 20 % (p>0.05). Conclusion: Thus, the study confirmed the high effectiveness of fast neutron therapy against malignant tumors of the salivary glands. Neutron therapy does not cause serious complications, encourages to increase of patients life expectancy and to decrease the number of relapses after combined treatment in comparison with standard methods of treatment.

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“…Parotid gland cancer comprises 0.5-1% of all malignances [1] and from 10% to 46% of all major salivary glands cancers. Therapeutic approach to parotid gland cancer is usually based on the combined modality treatment including surgery and radiation therapy [2,3]. Parotidectomy with resection of the facial nerve is performed most frequently and many authors consider this volume of surgery to be equal to the radical treatment.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Functional Factors and Life Quality of Patients with Parotid Gland Cancer after Multimodal Treatment Including Radiation Therapy

Choynzonov

Авдеенко²,

Balatskaya³

et al. 2015

AMR

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Patients with parotid gland cancer underwent parotidectomy followed by neutron therapy. Organ-preserving surgery with fascial nerve preservation was performed in 28 patients. Dynamics of recovery processes in n. facialis and mimic musculature innerveted by this facial nerve was assessed by electroneuromyographic method. The quantitative evaluation of the quality of life of patients was carried out in accordance with International Protocol of the European Organization for Research and Treatment of Cancer. Organ-preserving surgery followed by neutron therapy for parotid gland cancer was found to result no in significant functional impairments of mimic musculature, speech and eating, thus allowing the terms of social adaptation to be reduced and life quality of patients to be improved.

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Neutron therapy of resistant thyroid gland cancer

Cited by 4 publications

References 18 publications

Fast and Furious: Fast Neutron Therapy in Cancer Treatment

Fast and Furious: Fast Neutron Therapy in Cancer Treatment

Combined Treatment of Salivary Gland Cancer Patients with the Use of High-Let Radiation

Evaluation of Functional Factors and Life Quality of Patients with Parotid Gland Cancer after Multimodal Treatment Including Radiation Therapy

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