GFR or Gas-cooled Fast Reactor is one type of fast generation-IV that uses a very high cooling temperature. Thus, it is necessary to have the right reactor core design so that the power distribution of neutrons produced reaches a safe and even limit point. The use of a uniform (homogeneous) reactor core can produce peaking power. This is very avoidable because it will cause a reactor accident. In this study, researchers tried to compare the results of the analysis for two heterogeneous reactor core designs including the configuration of 3 fuel variations and 5 fuel variations using UN-PuN fuel. This study aims to determine the keff value produced by both types of fuel variations during 5 years of burn-up and determine the characteristics of neutron flux, fission rate, and fission product during 15 years of burn-up. This study was started by calculating the homogeneous and heterogeneous core of 3 and 5 fuel variations with neutron transport simulation involving OpenMC. The calculation results show that the heterogeneous core configuration of 5 fuel variations for the keff value is more optimal than 3 fuel variations, because it has the smallest excess reactivity value. The neutron flux and fission rate characteristics for 5 fuel variations are more evenly distributed when compared to 3 fuel variations to maintain neutron lifetime and reactor life in operation. Burn-up residual plutonium material and minor actinide waste for 5 fuel variations have less mass than 3 fuel variations. The results of neutronic analysis of GFR reactors with heterogeneous reactor core designs for 5 fuel variations are better in terms of reactor criticality, neutron power distribution, and waste produced. Finally, optimization of the UN-PuN fuel volume fraction of 60 % provides the optimal keff value