Neutropenia and neutrophil‐to‐lymphocyte ratio in a healthy Korean population: race and sex should be considered

Kweon, Oh Joo; Lee, M.-K.; Kim, H.-J.; Chung, Jin-Ho; Choi, Sehoon

doi:10.1111/ijlh.12489

Cited by 26 publications

(16 citation statements)

References 24 publications

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“…The NLR reference range has not been extensively studied. Kweon et al reported that the median NLR values are 1.53 and 1.54 for Korean men and women, respectively, and the upper 2.5 th percentile values are 3.51 and 3.54, respectively [ 51 ]. In Belgian subjects, the upper limit of the 95% CI is 3.53, with a mean of 1.65 [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Baseline peripheral blood neutrophil-to-lymphocyte ratio could predict survival in patients with adult polymyositis and dermatomyositis: A retrospective observational study

Hur

et al. 2018

PLoS ONE

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Recent studies have suggested that neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein-to-albumin ratio (CAR) are emerging markers of disease activity and prognosis in patients with chronic inflammatory diseases, cardiovascular diseases, or malignancies. Therefore, we investigated the clinical significance and prognostic value of the NLR and CAR in adult patients with polymyositis and dermatomyositis. The medical records of 197 patients with newly diagnosed polymyositis/dermatomyositis between August 2003 and November 2016 were retrospectively reviewed. Survival and causes of death were recorded during an average 33-month observational period. Clinical and laboratory findings were compared between survivors and non-survivors. Using receiver operating characteristic curves, the NLR and CAR cut-off values for predicting survival were calculated. Univariate and multivariate analyses using Cox proportional hazard models were performed to identify factors associated with survival. Twenty-six patients (13.2%) died during the study period, and the 5-year survival-rate was estimated to be 82%. The non-survivor group exhibited older age and a higher prevalence of interstitial lung disease (ILD), acute interstitial pneumonia, and acute exacerbation of ILD compared to that in the survivor group. NLR and CAR values were significantly higher in the non-survivors and in patients with polymyositis/ dermatomyositis-associated ILD, and the death rates increased across NLR and CAR quartiles. Furthermore, when stratified according to the NLR or CAR optimal cut-off values, patients with a high NLR (>4.775) or high CAR (>0.0735) had a significantly lower survival rate than patients with low NLR or CAR, respectively. In addition, old age (>50 years), the presence of acute interstitial pneumonia, hypoproteinemia (serum protein <5.5 g/dL), and high NLR (but not high CAR) were independent predictors for mortality. The results indicate PLOS ONE | https://doi.org/10.1371/journal.pone

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Section: Discussionmentioning

confidence: 99%

Baseline peripheral blood neutrophil-to-lymphocyte ratio could predict survival in patients with adult polymyositis and dermatomyositis: A retrospective observational study

Hur

et al. 2018

PLoS ONE

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“…Recently, in a multicenter cross-sectional study of a healthy Indian population, Sairam et al [ 39 ] found lower levels of platelets in elderly people. Kweon et al [ 40 ] investigated median PLRs in a healthy Korean population and suggested that the PLR cutoff values for disease evaluation should be established separately according to age. Therefore, we should consider age when evaluating the relationship between the PLR and mortality among critically ill patients with AKI.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of platelet-to-lymphocyte ratios among critically ill patients with acute kidney injury

et al. 2017

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BackgroundInflammation plays an important role in the initiation and progression of acute kidney injury (AKI). However, evidence regarding the prognostic effect of the platelet-to-lymphocyte ratio (PLR), a novel systemic inflammation marker, among patients with AKI is scarce. In this study, we investigated the value of the PLR in predicting the outcomes of critically ill patients with AKI.MethodsPatient data were extracted from the Multiparameter Intelligent Monitoring in Intensive Care Database III version 1.3. PLR cutoff values were determined using smooth curve fitting or quintiles and were used to categorize the subjects into groups. The clinical outcomes were 30-day and 90-day mortality in the intensive care unit (ICU). Cox proportional hazards models were used to evaluate the association between the PLR and survival.ResultsA total of 10,859 ICU patients with AKI were enrolled. A total of 2277 thirty-day and 3112 ninety-day deaths occurred. A U-shaped relationship was observed between the PLR and both 90-day and 30-day mortality, with the lowest risk being at values ranging from 90 to 311. The adjusted HR (95% CI) values for 90-day mortality given risk values < 90 and > 311 were 1.25 (1.12–1.39) and 1.19 (1.08–1.31), respectively. Similar trends were observed for 30-day mortality or when quintiles were used to group patients according to the PLR. Statistically significant interactions were found between the PLR and both age and heart rate. Younger patients (aged < 65 years) and those with more rapid heart rates (≥89.4 beats per minute) tended to have poorer prognoses only when the PLR was < 90, whereas older patients (aged ≥ 65 years) and those with slower heart rates (<89.4 beats per minute) had higher risk only when the PLR was > 311 (P < 0.001 for age and P < 0.001 for heart rate).ConclusionsThe preoperative PLR was associated in a U-shaped pattern with survival among patients with AKI. The PLR appears to be a novel, independent prognostic marker of outcomes in critically ill patients with AKI.

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“…A meta-analysis of 26 cross-sectional or longitudinal studies demonstrated that increased levels of C-reactive protein (CRP) in schizophrenic patients was parallel to the severity of positive symptoms but not associated with the initiation of antipsychotic medication; and the researchers suggested that CRP might be a marker of systemic low-grade inflammation [30]. The NLR can be derived from the white blood cell count, and is inexpensive, replicable and also it has been found to be significantly correlated with CRP [31]. It has been suggested as a new indicator of low-grade inflammation and a predictor of clinical outcomes inneuroimmune disorders [10,11].…”

Section: Discussionmentioning

confidence: 99%

The effect of electroconvulsive therapy on hematologic inflammatory markers in schizophrenia in association with type of antipsychotic medication

Önen

Taymur

2020

The European Research Journal

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Objectives: In recent years there has been an increased interest on the role of inflammation in the pathophysiology of schizophrenia and a search for readily applicable prognostic markers. The impact of electroconvulsive therapy (ECT) on inflammatory function in schizophrenia is still unclear. The aim of this retrospective study is to compare pre-and post-ECT values of red cell distribution width (RDW), mean platelet volume (MPV), mean cell hemoglobin (MCH), mean cell hemoglobin concentration (MCHC), neutrophil-tolymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) which are considered to be inflammatory markers, and to discuss the findings in context of neuroinflammatory ethiology of schizophrenia. Methods: Inpatient files were reviewed via complete blood count (CBC), sociodemographic and clinical characteristics (e.g. gender, age, Body Mass Index (BMI), type of psychotropic medication). A total of 58 schizophrenic patients who underwent ECT were were compared in terms of pre-and post-ECT values of RDW, MPV, MCH, MCHC, NLR and PLR in association with type of psychotropic medication. Results: It was found that MPV, RDW, MCH and MCHC levels significantly decreased after ECT (p < 0.05), but no significant difference was found in terms of NLR and PLR (p > 0.05). When compared according to the type of psychotropic medication during ECT, MPV and MCHC were decreased after ECT in both typicaland atypical antipsychoticintervention groups (p < 0.05). ECT-related inflammatory marker changes were more likely to be associated with atypical antipsychotic medication use during ECT. Conclusions: Our results indicate that recurrent ECT sessions caused a change in the function of the immune system which might be considered to explain the therapeutic effects of ECT in schizophrenia.

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Neutropenia and neutrophil‐to‐lymphocyte ratio in a healthy Korean population: race and sex should be considered

Abstract: Our data indicate that the normal range of absolute neutrophil counts should be adjusted and cutoff values for neutropenia should be re-established according to sex and race. NLR and PLR cutoff values for disease evaluation should be established separately according to race and age.

Cited by 26 publications

References 24 publications

Baseline peripheral blood neutrophil-to-lymphocyte ratio could predict survival in patients with adult polymyositis and dermatomyositis: A retrospective observational study

Baseline peripheral blood neutrophil-to-lymphocyte ratio could predict survival in patients with adult polymyositis and dermatomyositis: A retrospective observational study

Prognostic value of platelet-to-lymphocyte ratios among critically ill patients with acute kidney injury

The effect of electroconvulsive therapy on hematologic inflammatory markers in schizophrenia in association with type of antipsychotic medication

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