Neutropenia and Thrombocytopenia Induced By Quetiapine Monotherapy: A Case Report and Review of Literature

Arslan, Filiz Civil; Aykut, Demet Sağlam; İnce, Canan; Ti̇ryaki̇, Ahmet

doi:10.5455/bcp.20151219072235

Cited by 12 publications

(8 citation statements)

References 24 publications

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“…In patients with schizophrenia, quetiapine (600-1,200 mg/day, case reports) is associated with neutropenia, leukopenia (236-239), agranulocytosis, and thrombocytopenia (240). The mechanism by which quetiapine causes these adverse effects is still unclear, but some authors have proposed that this drug acts directly as a cytotoxic agent on immune cells, thus producing cell death; additionally, some products of quetiapine oxidation could induce apoptosis by oxidative stress (241). Other authors have suggested a bone marrow depression by quetiapine consumption, which could be produced by an inhibitory effect on leukopoiesis.…”

Section: Quetiapinementioning

confidence: 99%

Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics

et al. 2020

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Atypical antipsychotics (AAP) or second-generation antipsychotics are the clinical option for schizophrenia treatment during acute psychoses, but they are also indicated for maintenance during lifetime, even though they are being used for other psychiatric conditions in clinical practice such as affective disorders and autism spectrum disorder, among others. These drugs are differentiated from typical antipsychotics based on their clinical profile and are a better choice because they cause fewer side effects regarding extrapyramidal symptoms (EPS). Even though they provide clear therapeutic benefits, AAP induce peripheral effects that trigger phenotypic, functional, and systemic changes outside the Central Nervous System (CNS). Metabolic disease is frequently associated with AAP and significantly impacts the patient's quality of life. However, other peripheral changes of clinical relevance are present during AAP treatment, such as alterations in the immune and endocrine systems as well as the intestinal microbiome. These less studied alterations also have a significant impact in the patient's health status. This manuscript aims to revise the peripheral immunological, endocrine, and intestinal microbiome changes induced by AAP consumption recommended in the clinical guidelines for schizophrenia and other psychiatric disorders.

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Section: Quetiapinementioning

confidence: 99%

Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics

et al. 2020

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“…There are case reports that suggest development of agranulocytosis, neutropenia and thrombocytopenic purpura due to quetiapine. 9 , 11 – 13) Our patient didn’t have any abnormal clinical or laboratory test results except EEG disturbances before initiation of quetiapine treatment. Patient’s hematological and biochemical parameters were in normal range before quetiapine treatment.…”

Section: Discussionmentioning

confidence: 74%

Quetiapine Induced Autoimmune Hemolytic Anemia in a Child Patient: A Case Report

Arıcı

Altun

Acıpayam

2018

Clin Psychopharmacol Neurosci

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Autoimmune hemolytic anemia is a disease characterized with destruction of erythrocytes as a result of antibody produce against patient’s own erythrocytes and anemia. Autoimmune hemolytic anemia can be roughly stratified into two groups according to serological features and secondary causes including drugs induced hemolytic anemia. Drugs induced autoimmune hemolytic anemia is very rare in pediatric patients. Even though hematological side effects such as leucopenia, agranulocytosis, eosinophilia, thrombocytopenic purpura and aplastic anemia might occur due to psychotropic drug use; to the best of our knowledge there is no autoimmune hemolytic anemia case due to quetiapine, an atypical antipsychotics, in literature. We hereby describe the first child case of autoimmune hemolytic anemia during quetiapine treatment.We also are pointing out that one should keep in mind serious hematological side effects with atypical antipsychotic drug use with this case report.

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“…There are case reports that suggest development of agranulocytosis, neutropenia and thrombocytopenic purpura due to quetiapine. 9,[11][12][13] Our patient didn't have any abnormal clinical or laboratory test results except EEG disturbances before initiation of quetiapine treatment. Patient's hematological and biochemical parameters were in normal range before quetiapine treatment.…”

Section: -9)mentioning

confidence: 71%

Quetiapine Induced Autoimmune Hemolytic Anemia in a Child Patient: A Case Report

Arıcı

Altun

Acıpayam

2018

Clin Psychopharmacol Neurosci

View full text Add to dashboard Cite

Autoimmune hemolytic anemia is a disease characterized with destruction of erythrocytes as a result of antibody produce against patient's own erythrocytes and anemia. Autoimmune hemolytic anemia can be roughly stratified into two groups according to serological features and secondary causes including drugs induced hemolytic anemia. Drugs induced autoimmune hemolytic anemia is very rare in pediatric patients. Even though hematological side effects such as leucopenia, agranulocytosis, eosinophilia, thrombocytopenic purpura and aplastic anemia might occur due to psychotropic drug use; to the best of our knowledge there is no autoimmune hemolytic anemia case due to quetiapine, an atypical antipsychotics, in literature. We hereby describe the first child case of autoimmune hemolytic anemia during quetiapine treatment.We also are pointing out that one should keep in mind serious hematological side effects with atypical antipsychotic drug use with this case report.

show abstract

Neutropenia and Thrombocytopenia Induced By Quetiapine Monotherapy: A Case Report and Review of Literature

Cited by 12 publications

References 24 publications

Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics

Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics

Quetiapine Induced Autoimmune Hemolytic Anemia in a Child Patient: A Case Report

Quetiapine Induced Autoimmune Hemolytic Anemia in a Child Patient: A Case Report

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