Neutropenic Enterocolitis: An Uncommon, but Fearsome Complication of Leukemia

Babakhanlou, Rodrick; Ravandi‐Kashani, Farhad; Kontoyiannis, Dimitrios P.

doi:10.14740/jh1105

Cited by 5 publications

(17 citation statements)

References 37 publications

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“…The current approach to treating acute leukemia, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), incorporates the combination of potent chemotherapeutic agents and targeted molecular therapies with the goal of achieving complete remission (CR) or even cure [1][2][3][4]. Patients undergoing treatment for acute leukemia are at risk of life-threatening complications, either from the disease itself or from its therapy [3]. These complications can be either infectious or non-infectious, with a common involvement of the intestinal tract [3].…”

Section: Introductionmentioning

confidence: 99%

“…Patients undergoing treatment for acute leukemia are at risk of life-threatening complications, either from the disease itself or from its therapy [3]. These complications can be either infectious or non-infectious, with a common involvement of the intestinal tract [3]. Severe chemotherapy-induced neutropenia is one complication frequently observed, placing the patient at increased risk of infections [3,[5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…These complications can be either infectious or non-infectious, with a common involvement of the intestinal tract [3]. Severe chemotherapy-induced neutropenia is one complication frequently observed, placing the patient at increased risk of infections [3,[5][6][7][8]. Neutropenia is defined as an absolute neutrophil count (ANC) of < 1,500/µL and is being classified as mild, moderate and severe [3,[6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…Severe chemotherapy-induced neutropenia is one complication frequently observed, placing the patient at increased risk of infections [3,[5][6][7][8]. Neutropenia is defined as an absolute neutrophil count (ANC) of < 1,500/µL and is being classified as mild, moderate and severe [3,[6][7][8]. Severe neutropenia, defined as an ANC of < 500/µL, can be the result from intensive cytotoxic chemotherapy during the management of hematological malignancies [3,7].…”

Section: Introductionmentioning

confidence: 99%

“…Neutropenia is defined as an absolute neutrophil count (ANC) of < 1,500/µL and is being classified as mild, moderate and severe [3,[6][7][8]. Severe neutropenia, defined as an ANC of < 500/µL, can be the result from intensive cytotoxic chemotherapy during the management of hematological malignancies [3,7]. In up to 30% of cases, the gastrointestinal tract (GIT) is the source of infection in neutropenic patients, especially if neutropenia is prolonged or severe [6,9].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Anorectal Infections in Neutropenic Leukemia Patients: A Common Clinical Challenge

Babakhanlou,

Ravandi-Kashani,

Hita

et al. 2024

J Hematol

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Anorectal infections in neutropenic leukemia patients are a significant and potentially life-threatening complication. The pathogenesis of this condition is not entirely understood and believed to be multifactorial, including mucosal injury as a result of cytotoxic drugs, profound neutropenia and impaired host defense. Establishing an early diagnosis is key and often made clinically on the basis of signs and symptoms, but also from imaging studies demonstrating perianal inflammation or fluid collection. The management of anorectal infections in neutropenic leukemia patients is not straightforward, as there are no well-conducted studies on this entity. This review seeks to provide a framework into the pathophysiology and clinical presentation of anorectal infections in neutropenic leukemia patients, propose a diagnostic approach and to discuss controversies in the management of this condition.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Anorectal Infections in Neutropenic Leukemia Patients: A Common Clinical Challenge

Babakhanlou,

Ravandi-Kashani,

Hita

et al. 2024

J Hematol

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Case report: Herbal treatment of neutropenic enterocolitis after chemotherapy for breast cancer

Xu,

Cui,

Liu

et al. 2023

Open Life Sciences

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In this case report, a 53-year-old woman was diagnosed with severe NE after receiving chemotherapy for breast cancer. The patient with breast cancer was treated with a single cycle of docetaxel (140 mg) + epirubicin (130 mg) + cyclophosphamide (0.9 g) chemotherapy. However, the woman presented with symptoms of fatigue and diarrhea 5 days later accompanied with severe neutropenia according to the routine blood test. The computed tomography examination displayed the thickening and swelling of the colorectal wall. After the diagnosis of NE, the woman received antibiotics and supportive treatment, but her symptoms were not improved. The Chinese herbal medicine (CHM) diagnostic pattern was then designed for the patient. The patient was administered with two CHM decoctions. One decoction contained 24 kinds of herbal materials, and the other one was called pure ginseng decoction. These two decoctions were administered to the patient 2 or 3 times per day to tonify the spleen, nourish Qi and blood, and remove phlegm and damp heat symptoms. After the CHM treatment lasting for 10 days, the symptoms of the patient were improved, and she was discharged. In conclusion, CHM treatment played an indispensable role in curing the woman with chemotherapy-induced NE.

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Advanced Photocatalytic Degradation of Cytarabine from Pharmaceutical Wastewaters

Berbentea,

Ciopec,

Duteanu

et al. 2024

Toxics

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The need to develop advanced wastewater treatment techniques and their use has become a priority, the main goal being the efficient removal of pollutants, especially those of organic origin. This study presents the photo-degradation of a pharmaceutical wastewater containing Kabi cytarabine, using ultraviolet (UV) radiation, and a synthesized catalyst, a composite based on bismuth and iron oxides (BFO). The size of the bandgap was determined by UV spectroscopy, having a value of 2.27 eV. The specific surface was determined using the BET method, having a value of 0.7 m2 g−1. The material studied for the photo-degradation of cytarabine presents a remarkable photo-degradation efficiency of 97.9% for an initial concentration 0f 10 mg/L cytarabine Kabi when 0.15 g of material was used, during 120 min of interaction with UV radiation at 3 cm from the irradiation source. The material withstands five photo-degradation cycles with good results. At the same time, through this study, it was possible to establish that pyrimidine derivatives could be able to combat infections caused by Escherichia coli and Candida parapsilosis.

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Neutropenic Enterocolitis: An Uncommon, but Fearsome Complication of Leukemia

Cited by 5 publications

References 37 publications

Anorectal Infections in Neutropenic Leukemia Patients: A Common Clinical Challenge

Anorectal Infections in Neutropenic Leukemia Patients: A Common Clinical Challenge

Case report: Herbal treatment of neutropenic enterocolitis after chemotherapy for breast cancer

Advanced Photocatalytic Degradation of Cytarabine from Pharmaceutical Wastewaters

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