Neutrophil activation by Campylobacter concisus

Sørensen, Nina Breinholt; Nielsen, Hans Linde; Varming, Kim; Nielsen, Henrik

doi:10.1186/1757-4749-5-17

Cited by 17 publications

(12 citation statements)

References 21 publications

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“…In addition to CD11b upregulation, activated neutrophils typically undergo a NADPH-oxidase-dependent respiratory burst, resulting in the release of noxious reactive oxygen species (ROS) [13]. To evaluate neutrophil oxidative burst after parasite infection, we treated cells with DHR 123, a cell-permeable probe that converts into fluorescent Rho 123 upon oxidation [14].…”

Section: Resultsmentioning

confidence: 99%

Interactions between Neutrophils and Leishmania braziliensis Amastigotes Facilitate Cell Activation and Parasite Clearance

Carlsen¹,

Jie

Liang

et al. 2015

J Innate Immun

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Leishmania braziliensis and Leishmania amazonensis are both causative agents of cutaneous leishmaniasis in South America. However, patient prognosis and the host immune response differ considerably depending on the infecting parasite species. The mechanisms underlying these differences appear to be multifactorial, with both host and parasite components contributing to disease outcome. As neutrophils are a prominent component of the inflammatory infiltrate in chronic cutaneous, diffuse cutaneous and mucocutaneous lesions, we examined neutrophil activation and microbicidal activity against amastigotes of L. amazonensis and L. braziliensis. We found that murine neutrophils internalized L. braziliensis amastigotes with greater efficiency than did L. amazonensis amastigotes. Additionally, L. braziliensis infection was a potent trigger for neutrophil activation, oxidative burst, degranulation and the production of interleukin (IL)-22 and IL-10, while L. amazonensis amastigotes poorly induced these responses. Finally, neutrophils were able to kill L. braziliensis amastigotes, especially when cells were activated with phorbol myristate acetate. L. amazonensis amastigotes, however, were highly resistant to neutrophil microbicidal mechanisms. This study reveals, for the first time, differential neutrophil responsiveness to distinct species of Leishmania amastigotes and highlights the complexity of neutrophil-amastigote interactions during chronic leishmaniasis.

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Section: Resultsmentioning

confidence: 99%

Interactions between Neutrophils and Leishmania braziliensis Amastigotes Facilitate Cell Activation and Parasite Clearance

Carlsen¹,

Jie

Liang

et al. 2015

J Innate Immun

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“…Assays of interaction with epithelial cells [13][14][15][16] and neutrophil cells [30] demonstrate a pathogenic potential worthy of interest for the study of gastrointestinal disease.…”

Section: Discussionmentioning

confidence: 99%

Psychometric scores and persistence of irritable bowel afterCampylobacter concisusinfection

Nielsen¹,

Engberg

Ejlertsen

et al. 2014

Scandinavian Journal of Gastroenterology

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“…Some C. concisus strains, mostly those isolated from patients with IBD, have been shown to upregulate surface expression of lipopolysaccharides (LPS) receptors including Toll-like receptor (TLR) 4 and myeloid differentiation factor 2 in HT-29 cells (Ismail et al, 2013 ). Activation of neutrophil adherence molecule CD11b and oxidative burst response have been shown in neutrophils following C. concisus infection (Sørensen et al, 2013 ). Additionally, by using transcriptomics analysis, assembly of IFI16 inflammasome has been observed in both intestinal epithelial cells and macrophages following C. concisus infection (Kaakoush et al, 2015 ; Deshpande et al, 2016 ).…”

Section: Concisusmentioning

confidence: 99%

The Clinical Importance of Campylobacter concisus and Other Human Hosted Campylobacter Species

Liu

Wang

et al. 2018

Front. Cell. Infect. Microbiol.

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Historically, Campylobacteriosis has been considered to be zoonotic; the Campylobacter species that cause human acute intestinal disease such as Campylobacter jejuni and Campylobacter coli originate from animals. Over the past decade, studies on human hosted Campylobacter species strongly suggest that Campylobacter concisus plays a role in the development of inflammatory bowel disease (IBD). C. concisus primarily colonizes the human oral cavity and some strains can be translocated to the intestinal tract. Genome analysis of C. concisus strains isolated from saliva samples has identified a bacterial marker that is associated with active Crohn's disease (one major form of IBD). In addition to C. concisus, humans are also colonized by a number of other Campylobacter species, most of which are in the oral cavity. Here we review the most recent advancements on C. concisus and other human hosted Campylobacter species including their clinical relevance, transmission, virulence factors, disease associated genes, interactions with the human immune system and pathogenic mechanisms.

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Neutrophil activation by Campylobacter concisus

Cited by 17 publications

References 21 publications

Interactions between Neutrophils and <b><i>Leishmania braziliensis</i></b> Amastigotes Facilitate Cell Activation and Parasite Clearance

Interactions between Neutrophils and <b><i>Leishmania braziliensis</i></b> Amastigotes Facilitate Cell Activation and Parasite Clearance

Psychometric scores and persistence of irritable bowel afterCampylobacter concisusinfection

The Clinical Importance of Campylobacter concisus and Other Human Hosted Campylobacter Species

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