Neutrophil alkaline phosphatase activity in respiratory viral infection

Kubota, Masaru; Haruta, T

doi:10.1007/s10156-006-0480-9

Cited by 6 publications

(3 citation statements)

References 11 publications

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“…Muc1 expression is also quite high in sputum specimens taken from individuals with chronic obstructive lung disease (COPD). [ 91–95 ] All these data support the results of immunohistochemical staining from the present study.…”

Section: Discussionsupporting

confidence: 90%

Assessment of toxicological effects of favipiravir (T‐705) on the lung tissue of rats: An experimental study

Erbaş,

Celep,

Tekiner

et al. 2023

J Biochem & Molecular Tox

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This study aimed to present new data on the side effects of favipiravir on healthy lung tissue and the respiratory system. In the study, two different durations (5 and 10 days) were preferred to determine the effect of favipiravir treatment due to clinical improvement rates of approximately 5 and 10 days during the use of favipiravir in COVID‐19 patients. In addition, after 10 days of favipiravir treatment, animals were kept for 5 days without any treatment to determine the regeneration of lung tissues. Favipiravir was administered to rats by oral gavage at a daily dose of 200 mg/kg for 5 and 10 days, as in previous studies. At the end of the experiment, the histopathological and biochemical effects of favipiravir in the lung tissue were investigated. The data obtained from the study showed that favipiravir increased oxidative stress parameters, expression of apoptotic markers, and pro‐inflammatory markers in lung tissue. Since malondialdehydes is an oxidant parameter, it increased in favipiravir‐administered groups; It was determined that the antioxidant parameters glutathione, superoxide dismutase, glutathione peroxidase, and catalase decreased. Other markers used in the analysis are Bcl‐2, Bax, NF‐κB, interleukin (IL)‐6, Muc1, iNOS, P2X7R, IL‐6 and caspase‐3. The levels of Bax, caspase‐3, NF‐κB, IL‐6, Muc1, and P2X7R were increased in the Fav‐treated groups compared with the control. However, the levels of Bcl‐2 decreased in the Fav‐treated groups. The present study proves that favipiravir, widely used today, causes side effects in lung tissue.

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Section: Discussionsupporting

confidence: 90%

Assessment of toxicological effects of favipiravir (T‐705) on the lung tissue of rats: An experimental study

Erbaş,

Celep,

Tekiner

et al. 2023

J Biochem & Molecular Tox

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“…CRP on admission was significantly higher in LKD patients. They also had significantly higher NAP activity, a good marker for neutrophil activation 9 . These results indicate that the inflammatory response is stronger in LKD patients than in other‐KD patients.…”

Section: Resultsmentioning

confidence: 76%

Kawasaki disease with lymphadenopathy and fever as sole initial manifestations

Kubota

Usami

Yamakawa

et al. 2008

J Paediatrics Child Health

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“…Щелочная фосфатаза нейтрофилов находится преимущественно в специфических гранулах, и нормальные значения активности фермента могут колебаться в широких пределах, что может быть связано с созреванием гранул в ходе гранулоцитопоэза [13]. К моменту выхода нейтрофила в периферическую кровь содержание щелочной фосфатазы в клетках выше, чем в нейтрофилах костного мозга [13]. Имеются сведения о повышении активности фермента при острых бактериальных инфекциях [3].…”

Section: Discussionunclassified

The functional status of neutrophils in children with morbidity of chronic adenoiditis

Кологривова¹,

Плешко²,

Sherbik³

et al. 2017

Immunopathol Allergol Infectol

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Neutrophils have recently been attracting significant attention, due to appearance of new information on functional heterogeneity of this cell population that significantly determines pathways and features of pathological process. Objective: to determine morphological and functional features of neutrophils and structure of pharyngeal tonsil in children with adenoiditis and otitis media with effusion. Materials and Methods: In 38 children aged 3 to 7 years (25 - with uncomplicated chronic adenoiditis, 13 - with adenoiditis complicated with secretory otitis media) activity of acid and alkaline phosphatases and activity of cationic proteins was determined in peripheral blood neutrophils by cytochemical methods; NBT test was performed. Relative area of follicles, diffuse lymphoid tissue, blood vessels, fibrous tissue, as well as the presence and composition of intraepithelial infiltration, type of surface epithelium was evaluated on histological specimens of biopsies obtained during adenotomy (10 - in patients with uncomplicated chronic adenoiditis, 13 - with chronic adenoiditis complicated with secretory otitis media). Results: Decrease of the relative area of follicles (p = 0.04) as well as decline of the activity of acid phosphatase in the blood neutrophils [0.26 (0.22, 0.32) vs 0.32 (0.28; 0.36); p = 0.03] was observed during complicated course of chronic adenoiditis compared to uncomplicated form of the disease. Activity of oxygen-dependent mechanisms of cytotoxicity of peripheral blood neutrophils, assessed in NBT-test, did not differ between children with complicated and uncomplicated course of chronic adenoiditis. Conclusion: Reduced neutrophil acid phosphatase activity with intact ability to generate reactive oxygen species may be one of the causative factors of chronic adenoiditis, subepithelial morphological rearrangements in lymphoid tissue and development of exudative otitis media.

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Neutrophil alkaline phosphatase activity in respiratory viral infection

Cited by 6 publications

References 11 publications

Assessment of toxicological effects of favipiravir (T‐705) on the lung tissue of rats: An experimental study

Assessment of toxicological effects of favipiravir (T‐705) on the lung tissue of rats: An experimental study

Kawasaki disease with lymphadenopathy and fever as sole initial manifestations

The functional status of neutrophils in children with morbidity of chronic adenoiditis

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