Neutrophil anomaly and tuberculosis

Promyelocytic Leukaemoid Reaction: An Atypical Presentation of Mycobacterial Infection

“…Few abnor mal morphological features in tuberculosis have been reported [8,9]. Promyelocytes are not usually seen in the peripheral blood of normal individuals.…”

“…Neutrophil anomalies have been reported in tuber culosis [8,9]. One of these was Pelger-Huet nuclear anomaly [8], and the other was the abnormal peroxi dase-positive primary granules characteristic of Chediak-Steinbrink-Higashi syndrome [9], The former morphological abnormality is usually seen in myelo proliferative and preleukaemic disorders [11,12], Ca meron [3] has reported a case of tuberculosis pre senting as myelomonocytic leukaemia which showed a favourable response to antituberculous chemother apy.…”

“…One of these was Pelger-Huet nuclear anomaly [8], and the other was the abnormal peroxi dase-positive primary granules characteristic of Chediak-Steinbrink-Higashi syndrome [9], The former morphological abnormality is usually seen in myelo proliferative and preleukaemic disorders [11,12], Ca meron [3] has reported a case of tuberculosis pre senting as myelomonocytic leukaemia which showed a favourable response to antituberculous chemother apy. Albeit various mechanisms have been postulated to explain the blood dyscrasias in tuberculosis [3,13], the current view favours the immunological alteration of the body by disseminated tuberculosis [3,13].…”