Neutrophil anti-neutrophil cytoplasmic autoantibody proteins: bactericidal increasing protein, lactoferrin, cathepsin, and elastase as serological markers of inflammatory bowel and other diseases

Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract comprising Crohn’s disease and ulcerative colitis. Although the pathogenesis of the disease is not clearly defined yet, environmental, genetic and other factors contribute to the onset of the disease. Apart from the clinical and histopathological findings, several serological biomarkers are also employed to detect IBD. One of the most thoroughly studied biomarker is anti-neutrophil cytoplasmic autoantibody (ANCA). We herein provide an overview of the current knowledge on the use of ANCA and certain ANCA proteins, such as bactericidal increasing protein, lactoferrin, cathepsin G and elastase, as serological markers for IBD and other diseases.

MRP8/14 and neutrophil elastase for predicting treatment response and occurrence of flare in patients with juvenile idiopathic arthritis

“…This biomarker has not been studied in JIA with regard to treatment response and flare prediction. NE has been assessed in respiratory diseases [ 12 ] and auto-immune inflammatory bowel disorders [ 13 ], and generally serves as a marker of inflammation.…”

Use of a Granulocyte Immunofluorescence Assay Designed for Humans for Detection of Antineutrophil Cytoplasmic Antibodies in Dogs with Chronic Enteropathies

“…In human patients with ulcerative colitis, pANCA are more commonly identified in patients with a more clinically aggressive disease course . The PR‐3 autoantibodies may be of importance in ulcerative colitis, and their presence has been documented in this disease . Due to the nature of our study, prospective follow‐up on patients with ANCA was not possible.…”

“…15 The PR-3 autoantibodies may be of importance in ulcerative colitis, and their presence has been documented in this disease. 16 Due to the nature of our study, prospective follow-up on patients with ANCA was not possible. The small number of patients in which specific antigen identification was observed may further support a loss of sensitivity by ANCA, antineutrophil cytoplasmic antibodies; SCWT, softcoated wheaten terrier; PLE/PLN, protein-losing enteropathy/protein-losing nephropathy.…”

“…Alternatively, the underlying antigen may be different in the majority of affected dogs. In humans, the main ANCA proteins that have been identified are lactoferrin, elastase and bactericidal increasing protein . Further research to identify the specific proteins targeted by canine ANCA is required, although they may be similar to those documented in human patients.…”

The diagnostic and prognostic value of serological markers of inflammatory bowel diseases (a literature review)

“…Основной антигенной мишенью сANCA выступает протеиназа 3 (PR3), pANCA -миелопероксидаза, классические высокоспецифичные маркеры ANCA-ассоциированных васкулитов. Атипичный паттерн свечения xANCA определяется различными антигенами нейтрофильных гранул, включая эластазу, катепсин G, лактоферрин, лизоцим, бактерицидный, увеличивающий проницаемость белок (BPI), азурозидин, и отмечается у пациентов c аутоиммунным гепатитом (50%), ПСХ (40%), ПБХ (5%), ревматоидным артритом (5-10%) и ВЗК [34,35].…”