Neutrophil Chemotaxis in Patients with Pustulotic Arthro-Osteitis

Jurik, Anne Grethe; Ternowitz, Thomas; Graudal, H

doi:10.1159/000248698

Cited by 10 publications

(3 citation statements)

References 20 publications

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“…Bone scan generally shows increased activity in the affected sites. Treatment is usually symptomatic with NSAID, with limited success, although there are reports of successful treatment with colchicine [14,15].…”

Section: Discussionmentioning

confidence: 99%

SAPHO Syndrome

et al. 1993

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Four women with pustulosis palmoplantaris (PPP) and associated sternocostoclavicular hyperostosis are described. The connection between the two diseases is not coincidental: it is encountered in 9.4% of PPP patients, and was reported in the French literature as part of the SAPHO (synovitis acne pustulosis hyperostosis osteomyelitis) syndrome. This syndrome is linked to the spondyloarthropathies, having an increased prevalence of HLA B27 and occurrence of sacroiliitis. None of our patients had HLA B27, but HLA A26 was found in the 3 patients examined. No conclusion can be drawn from this finding, however, since this antigen is found in 21.7% of Ashkenazi Jews. Recognition of this syndrome by dermatologists will improve diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

SAPHO Syndrome

et al. 1993

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“…Limited evidence suggests that sulfasalazine may be used as an adjunct in combination with other drugs in the treatment of SAPHO [77]. Colchicine is used in some areas because of its known efficacy in neutrophil inhibition [17,78]. Apremilast, a phosphodiesterase-4 inhibitor, was reported efficient in a small series of patients [79].…”

Section: Treatment Of Synovitis Acne Pustulosis Hyperostosis and Oste...mentioning

confidence: 99%

Pro and contra: is synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) a spondyloarthritis variant?

Furer

Kishimoto

Tomita

et al. 2022

Current Opinion in Rheumatology

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Purpose of reviewThe purpose of this review is to present the up-to-date evidence on the epidemiology, pathogenesis, musculoskeletal manifestations, and imaging of the synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome and to discuss its relationship with spondyloarthritis (SpA).Recent findingsSAPHO is a rare inflammatory disorder of bone, joints, and skin, with a worldwide distribution that predominantly affects the middle-age adults. The hallmark of the syndrome is a constellation of sterile inflammatory osteitis, hyperostosis, and synovitis involving the anterior chest wall, associated with acneiform and neutrophilic dermatoses, such as palmoplantar pustulosis and severe acne. The axial skeleton, sacroiliac, and peripheral joints can be involved in a similar fashion to SpA. The pathogenesis of the syndrome is multifactorial. The diagnosis is mainly based on the clinical and typical radiological features. The treatment approach is based on the off-label use of antibiotics, bisphosphonates, disease-modifying antirheumatic drugs, and anticytokine biologics.SummaryThe SAPHO syndrome shares common features with SpA-related diseases, yet also shows some unique pathogenetic and clinical features. The nosology of SAPHO remains a subject of controversy, awaiting further research into the pathogenetic and clinical aspects of this syndrome. A better understanding of these aspects will improve the diagnostics and clinical care of patients with SAPHO.

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“…Um diese heterogene Erkrankung abzubilden, wurden in der Literatur verschiedene Begrifflichkeiten verwendet wie z. B. nichtbakterielle Osteitis (NBO), chronisch sklerosierende Osteomyelitis und pustulöse Arthroosteitis 1 – 4 . International hat sich im Kindesalter weitgehend der Begriff der CNO durchgesetzt.…”

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Die Chronisch Nichtbakterielle Osteomyelitis (CNO) im Kindes- und Jugendalter

Schnabel,

Girschick,

Hahn

et al. 2023

Arthritis und Rheuma

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ZUSAMMENFASSUNGDie CNO zählt zu den autoinflammatorischen Knochenerkrankungen mit dem Leitsymptom muskuloskelettaler Schmerz. Das breite klinische Spektrum, das Fehlen validierter Diagnosekriterien und die unvollständig verstandene Pathophysiologie machen die Diagnose CNO zu einer Herausforderung. Die Patienten können systemische Entzündungszeichen aufweisen, pathognomonische Laborbefunde existieren jedoch nicht. Die Ganzkörper-Magnetresonanztomografie stellt mittlerweile den Goldstandard (bei Verfügbarkeit) in der CNO-Diagnostik dar. Der histologische Befund einer Knochenbiopsie zeigt kein CNO-spezifisches Entzündungsmuster, kann aber bei unifokaler/atypischer Manifestation für die Differenzierung zu Malignität oder bakteriellen Infektionen notwendig sein. In erster Linie kommen therapeutisch nichtsteroidale Antirheumatika (NSAR) zum Einsatz. In refraktären Fällen oder bei Wirbelsäulenbeteiligung sollte auf Zweitlinien-Medikamente wie Bisphosphonate oder TNF-Inhibitoren zurückgegriffen werden. Der Krankheitsverlauf ist schwer vorhersehbar. Da eine unkontrollierte Krankheitsaktivität zu Komplikationen wie Wirbelkörperfrakturen führen kann, ist eine zeitnahe Diagnosestellung und Therapie wichtig für den Krankheitsverlauf.

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Neutrophil Chemotaxis in Patients with Pustulotic Arthro-Osteitis

Cited by 10 publications

References 20 publications

SAPHO Syndrome

SAPHO Syndrome

Pro and contra: is synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) a spondyloarthritis variant?

Die Chronisch Nichtbakterielle Osteomyelitis (CNO) im Kindes- und Jugendalter

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