Neutrophil Count on Admission Predicts Acute Symptomatic Hydrocephalus After Aneurysmal Subarachnoid Hemorrhage

Cuoco, Joshua A.; Guilliams, Evin L.; Klein, Brendan J.; Benko, Michael J.; Darden, Jordan; Olasunkanmi, Adeolu; Witcher, Mark R.; Rogers, Cara M.; Marvin, Eric A.; Patel, Biraj M.; Entwistle, John J.

doi:10.1016/j.wneu.2021.09.059

Cited by 9 publications

(6 citation statements)

References 25 publications

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“…There was only one study with adjusted estimates for acute hydrocephalus for women compared to men (OR 0.67, 95% CI 0.18–2.43) and was not included in the meta-analysis [ 6 ]. There was one study [ 13 ] with the adjusted estimates (OR 0.5, 95% CI 0.13–10.19) for chronic hydrocephalus in men compared to women that were not significant for the male sex and not included in the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

Is sex a predictor for delayed cerebral ischaemia (DCI) and hydrocephalus after aneurysmal subarachnoid haemorrhage (aSAH)? A systematic review and meta-analysis

et al. 2022

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Objectives DCI and hydrocephalus are the most common complications that predict poor outcomes after aSAH. The relationship between sex, DCI and hydrocephalus are not well established; thus, we aimed to examine sex differences in DCI and hydrocephalus following aSAH in a systematic review and meta-analysis. Methods A systematic search was conducted using the PubMed, Scopus and Medline databases from inception to August 2022 to identify cohort, case control, case series and clinical studies reporting sex and DCI, acute and chronic shunt-dependent hydrocephalus (SDHC). Random-effects meta-analysis was used to pool estimates for available studies. Results There were 56 studies with crude estimates for DCI and meta-analysis showed that women had a greater risk for DCI than men (OR 1.24, 95% CI 1.11–1.39). The meta-analysis for adjusted estimates for 9 studies also showed an association between sex and DCI (OR 1.61, 95% CI 1.27–2.05). For acute hydrocephalus, only 9 studies were included, and meta-analysis of unadjusted estimates showed no association with sex (OR 0.95, 95%CI 0.78–1.16). For SDHC, a meta-analysis of crude estimates from 53 studies showed that women had a somewhat greater risk of developing chronic hydrocephalus compared to men (OR 1.14, 95% CI 0.99–1.31). In meta-analysis for adjusted estimates from 5 studies, no association of sex with SDHC was observed (OR 0.87, 95% CI 0.57–1.33). Conclusions Female sex is associated with the development of DCI; however, an association between sex and hydrocephalus was not detected. Strategies to target females to reduce the development of DCI may decrease overall morbidity and mortality after aSAH.

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Section: Resultsmentioning

confidence: 99%

Is sex a predictor for delayed cerebral ischaemia (DCI) and hydrocephalus after aneurysmal subarachnoid haemorrhage (aSAH)? A systematic review and meta-analysis

et al. 2022

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“…Although white blood cells only account for 0.2% of whole blood, they play an important role in protecting human health [1]. White blood cells are generally divided into neutrophils, eosinophils, basophils, monocytes, and lymphocytes [2], and changes in these cell counts can be used as the basis for diagnosing certain diseases or evaluating the therapeutic efect of certain diseases [3][4][5][6][7][8][9]. Terefore, the accuracy and efciency of white blood cell detection and classifcation are very important for the auxiliary diagnosis of diseases [10].…”

Section: Introductionmentioning

confidence: 99%

A Method for Expanding the Training Set of White Blood Cell Images

Yang

Zang

et al. 2022

Journal of Healthcare Engineering

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In medicine, the count of different types of white blood cells can be used as the basis for diagnosing certain diseases or evaluating the treatment effects of diseases. The recognition and counting of white blood cells have important clinical significance. But the effect of recognition based on machine learning is affected by the size of the training set. At present, researchers mainly rely on image rotation and cropping to expand the dataset. These methods either add features to the white blood cell image or require manual intervention and are inefficient. In this paper, a method for expanding the training set of white blood cell images is proposed. After rotating the image at any angle, Canny is used to extract the edge of the black area caused by the rotation and then fill the black area to achieve the purpose of expanding the training set. The experimental results show that after using the method proposed in this paper to expand the training set to train the three models of ResNet, MobileNet, and ShuffleNet, and comparing the original dataset and the method trained by the simple rotated image expanded dataset, the recognition accuracy of the three models is obviously improved without manual intervention.

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“…Previously, our group found that a neutrophil count ≥9.80 × 10 3 /uL on admission was predictive of acute symptomatic hydrocephalus after aneurysmal subarachnoid hemorrhage in an adjusted multivariate logistic regression model ( 14 ). Secondary analysis demonstrated that 81.25% of patients who developed shunt dependence exhibited a neutrophil count ≥9.80 × 10 3 /uL on admission (p = 0.003) ( 14 ). Here, we sought to further investigate this preliminary finding in an independent analysis to evaluate for potential associations between immunologic counts on admission and shunt-dependent hydrocephalus following aSAH.…”

Section: Introductionmentioning

confidence: 98%

“…In the context of aSAH, there is growing evidence to suggest that an immune-mediated inflammatory response in the central nervous system is a key mechanism of early brain injury following rupture and associated clinical sequelae ( 9 , 10 ). Data from pre-clinical and clinical studies have demonstrated the activation and proliferation of various leukocyte subsets (e.g., neutrophils, monocytes) following aSAH in murine models and humans ( 9 – 14 ). Previously, our group found that a neutrophil count ≥9.80 × 10 3 /uL on admission was predictive of acute symptomatic hydrocephalus after aneurysmal subarachnoid hemorrhage in an adjusted multivariate logistic regression model ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

“…Data from pre-clinical and clinical studies have demonstrated the activation and proliferation of various leukocyte subsets (e.g., neutrophils, monocytes) following aSAH in murine models and humans ( 9 – 14 ). Previously, our group found that a neutrophil count ≥9.80 × 10 3 /uL on admission was predictive of acute symptomatic hydrocephalus after aneurysmal subarachnoid hemorrhage in an adjusted multivariate logistic regression model ( 14 ). Secondary analysis demonstrated that 81.25% of patients who developed shunt dependence exhibited a neutrophil count ≥9.80 × 10 3 /uL on admission (p = 0.003) ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

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Monocyte Count on Admission Is Predictive of Shunt-Dependent Hydrocephalus After Aneurysmal Subarachnoid Hemorrhage

et al. 2022

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The authors sought to evaluate whether immunologic counts on admission were associated with shunt-dependent hydrocephalus following aneurysmal subarachnoid hemorrhage. A retrospective analysis of 143 consecutive patients with aneurysmal subarachnoid hemorrhage over a 9-year period was performed. A stepwise algorithm was followed for external ventricular drain weaning and determining the necessity of shunt placement. Data were compared between patients with and without shunt-dependent hydrocephalus. Overall, 11.19% of the cohort developed shunt-dependent hydrocephalus. On multivariate logistic regression analysis, acute hydrocephalus (OR: 61.027, 95% CI: 3.890–957.327; p = 0.003) and monocyte count on admission (OR: 3.362, 95% CI: 1.024–11.037; p = 0.046) were found to be independent predictors for shunt dependence. Receiver operating characteristic curve analysis for the prediction of shunt-dependent hydrocephalus confirmed that monocyte count exhibited an acceptable area under the curve (AUC = 0.737, 95% CI: 0.601–0.872; p < 0.001). The best predictive cutoff value to discriminate between successful external ventricular drain weaning and shunt-dependent hydrocephalus was identified as a monocyte count ≥0.80 × 103/uL at initial presentation. These preliminary data demonstrate that a monocyte count ≥0.80 × 103/uL at admission predicts shunt-dependent hydrocephalus in patients with aneurysmal subarachnoid hemorrhage; however, further large-scale prospective trials and validation are necessary to confirm these findings.

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Neutrophil Count on Admission Predicts Acute Symptomatic Hydrocephalus After Aneurysmal Subarachnoid Hemorrhage

Cited by 9 publications

References 25 publications

Is sex a predictor for delayed cerebral ischaemia (DCI) and hydrocephalus after aneurysmal subarachnoid haemorrhage (aSAH)? A systematic review and meta-analysis

Is sex a predictor for delayed cerebral ischaemia (DCI) and hydrocephalus after aneurysmal subarachnoid haemorrhage (aSAH)? A systematic review and meta-analysis

A Method for Expanding the Training Set of White Blood Cell Images

Monocyte Count on Admission Is Predictive of Shunt-Dependent Hydrocephalus After Aneurysmal Subarachnoid Hemorrhage

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