Neutrophil/eosinophil‐rich type of primary cutaneous anaplastic large cell lymphoma: a clinicopathological, immunophenotypic and molecular study of nine cases

Kong, Yunyi; Dai, Bo; Kong, Jincheng; Lu, Haizhou; Shi, Daren

doi:10.1111/j.1365-2559.2009.03359.x

Cited by 26 publications

(13 citation statements)

References 14 publications

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“…Although the conventional variant does not have a predilection for immunocompromised individuals, the pyogenic variant is seen in those with HIV, 15 transplant recipients, 16 and hematologic malignancies including young individuals. 10,17 Microscopically, ALCL has diffuse, cohesive sheets of large pleomorphic tumor cells, strongly CD30þ, similar to ALKþ ALCL ( Figure 1). Even among the conventional variants, a rich inflammatory infiltrate is present, which can lead to a misdiagnosis of an inflammatory process in the skin.…”

Section: Lymphoproliferative Neoplasms Mature T-cell and Nk-cell Lympmentioning

confidence: 99%

Cutaneous Hematolymphoid and Histiocytic Proliferations in Children

Gru

Dehner

2018

Pediatr Dev Pathol

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This article focuses on cutaneous hematopoietic neoplasms that are more likely to be encountered in the pediatric age-group and includes both lymphoproliferative and histiocytic disorders. The cutaneous hematologic disorders in children have a different epidemiologic profile to what is seen during adulthood. Although mycosis fungoides is the most frequent form of cutaneous lymphoma in adults, it is very rare in children. Because lymphoblastic leukemias and lymphomas are more frequent in the pediatric setting, cutaneous leukemic infiltrates are relatively common in this age-group. Similarly, histiocytic disorders are more common in children, particularly Langerhans cell histiocytosis and juvenile xanthogranuloma. Notably, the histiocytic disorders have undergone significant modifications on their nomenclature in the basis of the molecular characteristics that are present in them. A summary of the most frequent cutaneous hematopoietic disorders in children will be discussed further in this review.

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Section: Lymphoproliferative Neoplasms Mature T-cell and Nk-cell Lympmentioning

confidence: 99%

Cutaneous Hematolymphoid and Histiocytic Proliferations in Children

Gru

Dehner

2018

Pediatr Dev Pathol

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“…Of these 11 cases, 5 also lacked CD4 and CD8 expression. 7,9,[21][22][23][24][25][26] Only 1 of our CD4 2 / CD8 2 cases expressed TIA-1, demonstrating that most of these double-negative cases do not express a cytotoxic phenotype. Although several studies reported on loss of T-cell markers expression, detailed phenotypic aberrations and loss of all T-cell markers were never described.…”

Section: Discussionmentioning

confidence: 99%

Phenotypic Variability in Primary Cutaneous Anaplastic Large T-cell Lymphoma

Massone

Cerroni

2014

The American Journal of Dermatopathology

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Primary cutaneous anaplastic large T-cell lymphoma (pcALCL) is a well-defined entity characterized by neoplastic cells expressing CD30, CD2, CD3, CD4, and CD5. Cases with different phenotype have been reported, including variable loss of CD2, CD3, and CD5, and expression of cytotoxic phenotype (CD8⁺) and/or of cytotoxic proteins. Aberrant phenotypes represent a diagnostic pitfall and may be the cause of misdiagnoses. We reviewed 35 cases of pcALCL (M:F = 19:16; mean age, 50.8 years; range, 14-92 years), to better characterize the immunophenotypic spectrum of the disease. Twelve cases (34%) had a T-helper phenotype (CD4⁺/CD8⁻), and TIA-1 was positive in 5 of 8 stained cases. Six cases (18%) had a T-cytotoxic phenotype (CD4⁻/CD8⁺) and were also positive for TIA-1. Positivity for both CD4 and CD8 was observed in 7 cases (20%), 4 of which were stained for TIA-1 and found to be positive, whereas both CD4 and CD8 were negative in 9 cases (26%, only 1/8 tested cases being TIA-1 positive). CD2 was positive in 21 of 27 tested cases (78%), CD3 in 21 of 34 cases (62%), and CD5 in 15 of 31 cases (48%). Interestingly, 11 cases (31%) showed a profoundly aberrant phenotype lacking simultaneously several T-cell markers. Our data allow a better characterization of pcALCL with aberrant phenotypes, showing the remarkable variability in expression of different markers.

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“…Both solid tumors and hematopoietic neoplasms are associated with eosinophilia. Eosinophilia and tissue eosinophilia are frequent findings in Hodgkin lymphoma [ 25 ] and are sometimes observed in patients with lymphoma, predominantly T cell lymphoma or occasionally anaplastic large cell lymphoma [ 26 , 27 ]. Historically, large B cell lymphoma with marked eosinophilia is rare, and only a few cases of mediastinal/thymic large B cell lymphoma may present a few reactive infiltrating lymphocytes and eosinophils.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis of primary pulmonary T- cell/histiocyte-rich large B cell lymphoma with tissue eosinophilia via clinicopathological observation and molecular assay

et al. 2014

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Background: Primary pulmonary lymphoma (PPL) is rare and easily misdiagnosed because of the lack of typical clinical features. It most commonly involves elderly patients aged between 60 and 70 years, and pathological diagnosis depends mainly on chest surgery rather than bronchial mucosal biopsy. Via percutaneous needle aspiration biopsy of the lung of a 33-year-old woman, which had distinct tissue eosinophilia, we diagnosed a rare case of rapidly growing large B cell lymphoma. Methods: Bronchial mucosal biopsy and computed tomography-guided percutaneous needle aspiration biopsy were performed to determine the nature of the lesion, and we identified its immunophenotype using immunohistochemistry. We used BIOMED-2 gene rearrangement PCR to determine lymphocyte clonality; laser microdissection was used to confirm the clonality of suspicious malignant lymphocytes.

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Neutrophil/eosinophil‐rich type of primary cutaneous anaplastic large cell lymphoma: a clinicopathological, immunophenotypic and molecular study of nine cases

Cited by 26 publications

References 14 publications

Cutaneous Hematolymphoid and Histiocytic Proliferations in Children

Cutaneous Hematolymphoid and Histiocytic Proliferations in Children

Phenotypic Variability in Primary Cutaneous Anaplastic Large T-cell Lymphoma

Diagnosis of primary pulmonary T- cell/histiocyte-rich large B cell lymphoma with tissue eosinophilia via clinicopathological observation and molecular assay

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