2020
DOI: 10.1016/j.intimp.2020.106902
|View full text |Cite
|
Sign up to set email alerts
|

Neutrophil extracellular traps promote corneal neovascularization-induced by alkali burn

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

3
17
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 30 publications
(20 citation statements)
references
References 19 publications
3
17
0
Order By: Relevance
“…Though the direct evidence of NETs in angiogenesis and vascular permeability in the context of tumor is scarce, a functional link between NETs and angiogenesis has been implicated in tissue repair [ 63 ] as well as in vascular pathology, including pulmonary hypertension [ 64 ] and corneal neovascularization [ 65 ]. The possible mechanism could be NETs-mediated activation of endothelial cells via TLR-4/ NFκB signalling [ 64 ], inflammation-induced upregulation of proangiogenic factors such as vascular endothelial growth factor (VEGF) [ 65 , 66 ] , and the newly identified mechanism relying on the NETs clearance of senescent endothelial cells [ 67 ]. In addition to angiogenesis, NETs have been found to increase vascular permeability by disrupting the endothelial barrier.…”
Section: Nets Promote Metastasismentioning
confidence: 99%
“…Though the direct evidence of NETs in angiogenesis and vascular permeability in the context of tumor is scarce, a functional link between NETs and angiogenesis has been implicated in tissue repair [ 63 ] as well as in vascular pathology, including pulmonary hypertension [ 64 ] and corneal neovascularization [ 65 ]. The possible mechanism could be NETs-mediated activation of endothelial cells via TLR-4/ NFκB signalling [ 64 ], inflammation-induced upregulation of proangiogenic factors such as vascular endothelial growth factor (VEGF) [ 65 , 66 ] , and the newly identified mechanism relying on the NETs clearance of senescent endothelial cells [ 67 ]. In addition to angiogenesis, NETs have been found to increase vascular permeability by disrupting the endothelial barrier.…”
Section: Nets Promote Metastasismentioning
confidence: 99%
“…To further support metastatic colocalization, the pre-metastatic niche may enhance angiogenesis and vascular permeability. Despite the lack of direct evidence of NETs in tumor angiogenesis and vascular permeability, a functional relationship between NETs and angiogenesis has been proposed in tissue regeneration as well as in vascular disease [ 20 , 101 , 102 ]. NET-embedded proteases such as neutrophil elastase (NE), myeloperoxidase (MPO), and matrix metalloproteases (MMP) are shown to cleave the vascular endothelial cadherin that compromises junction integrity, thus promoting vascular permeability [ 103 ].…”
Section: Neutrophil Extracellular Traps In Cancer Metastasismentioning
confidence: 99%
“…The role of NETs in corneal wound healing and homeostasis is not clearly known. However, previous studies reported that NETs were detected on the ocular surface in dry eye disease (DED) and other corneal disorders such as alkali burn, indicating that the presence of NETs in the precorneal and cornea may induce corneal inflammation and corneal neovascularization [ 66 , 67 ]. The mediators released from the activated macrophages attract more immune cells for the wound healing process.…”
Section: Wound Healingmentioning
confidence: 99%