Neutrophil extracellular traps promote M1 macrophage polarization in gouty inflammation via targeting hexokinase-2

Tan, Haibo; Zhang, Shan; Zhang, Zhihao; Zhang, Jianyong; Wang, Ziyu; Liao, Junlan; Qiu, Xia; Jia, Ertao

doi:10.1016/j.freeradbiomed.2024.09.009

Free Radical Biology and Medicine

2024

DOI: 10.1016/j.freeradbiomed.2024.09.009

|View full text |Cite

Neutrophil extracellular traps promote M1 macrophage polarization in gouty inflammation via targeting hexokinase-2

Haibo Tan,

Shan Zhang,

Zhihao Zhang

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Bioactivity-Oriented Separation of “Pepper Alkaloids” from Piper sintenense Hatusima with Potential Antigouty Arthritis Activity

Yao,

Li,

Jin

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

Piper sintenense Hatusima (PsH) is a member of the Piper genus used as food and folk medicine in China. However, the detailed chemical ingredients and potential pharmacological effects are still underexploited. In this study, we evaluated the antiinflammatory and antigouty arthritis effect of the ethanolic extract of P. sintenense. Active compounds were isolated from the petroleum ether fraction resulting in six novel amide alkaloids (1−6) and 13 known analogues (7−19). All of the compounds exhibited excellent anti-inflammatory activities. Bioinformatics analysis and in vitro experiments showed that compound 4 had antiinflammatory properties (IC 50 = 4.86 ± 0.32 μM) and antigouty arthritis activity. Mechanistic studies revealed that compound 4 exerted its favorable efficacy by regulating macrophage polarization by inhibiting P-STAT1/4. These findings provide new insights into the chemical composition and function of P. sintenense and expand its promising application as a functional food in the prevention and treatment of gouty arthritis.

show abstract

Bioactivity-Oriented Separation of “Pepper Alkaloids” from Piper sintenense Hatusima with Potential Antigouty Arthritis Activity

Yao,

Li,

Jin

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Neutrophil extracellular traps promote M1 macrophage polarization in gouty inflammation via targeting hexokinase-2

Cited by 1 publication

References 41 publications

Bioactivity-Oriented Separation of “Pepper Alkaloids” from Piper sintenense Hatusima with Potential Antigouty Arthritis Activity

Bioactivity-Oriented Separation of “Pepper Alkaloids” from Piper sintenense Hatusima with Potential Antigouty Arthritis Activity

Contact Info

Product

Resources

About