Neutrophil Function Disorders

Comazzi, S.; Aresu, Luca; Weiss, Douglas J.

doi:10.1002/9781119500537.ch44

Cited by 2 publications

(5 citation statements)

References 29 publications

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“…However, the genotype associated with the Pelger–Huët phenotype in animals was not known 2 . While in humans, this condition has an autosomal dominant inheritance pattern, in animals, this inherited disorder has traditionally been considered an autosomal dominant trait with incomplete penetrance, in which heterozygous animals have the typical phenotype (hyposegmentation) but are usually without clinical signs 2,3 . In Australian Shepherd dogs, Pelger–Huët anomaly is now known to be caused by a splice site mutation in the LMBR1L (Limb Development Membrane Protein 1 Like) gene and has an autosomal recessive mode of inheritance 4…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to the typical Pelger–Huët anomaly, an acquired condition (pseudo‐Pelger–Huët anomaly) has been described that is usually transient and secondary to inflammation, myeloid neoplasms, administration of certain drugs or myelodysplasia with asynchronous neutrophil maturation 2,3 . Typically, cases of pseudo‐Pelger–Huët anomaly show only a minority of hyposegmented cells, as opposed to the inherited form in which most cells are affected 2 .…”

Section: Discussionmentioning

confidence: 99%

“…Neutrophils (and other cells such as eosinophils, basophils, or megakaryocytes) appear with a hypolobulated or even round nuclei due to a failure in nuclear segmentation, with a clumped chromatin pattern and absence of toxic change. 2,3 In humans, the underlying causative mutation involves the gene encoding the Lamin B receptor (an integral membrane protein in the nuclear envelope). However, the genotype associated with the Pelger-Huët phenotype in animals was not known.…”

Section: Discussionmentioning

confidence: 99%

“…Peripheral blood smear micrographs on Day 48 from a dog with pseudo-Pelger-Huët anomaly, showing hyposegmented neutrophils and eosinophils, basophils (arrowhead), lymphocytes and segmented neutrophils (asterisks). Modified Wright stain, original magnification ×100 objective.In contrast to the typical Pelger-Huët anomaly, an acquired condition (pseudo-Pelger-Huët anomaly) has been described that is usually transient and secondary to inflammation, myeloid neoplasms, administration of certain drugs or myelodysplasia with asynchronous neutrophil maturation 2,3. Typically, cases of pseudo-Pelger-Huët anomaly show only a minority of hyposegmented cells, as opposed to the inherited form in which most cells are affected 2.…”

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confidence: 99%

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Presumed pseudo‐Pelger–Huët anomaly and basophilia secondary to chronic lymphocytic leukemia in a dog

Martínez‐Caro,

Agulla,

Viñeta

et al. 2024

Veterinary Clinical Pathol

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A 10‐year‐old neutered male Maltese dog was presented for an investigation of lymphocytosis. The dog was up‐to‐date on vaccinations and deworming. Physical examination did not reveal any significant abnormalities. A complete blood cell count (CBC) showed mild leukocytosis with moderate lymphocytosis, basophilia, and moderate neutropenia, but no significant left shift or toxic change. Serum biochemistry and urinalysis were unremarkable. All performed tests for infectious agents common in this geographical region were negative. No significant abnormalities were found on abdominal ultrasound examination. Multiparametric flow cytometry of peripheral blood showed a CD8+ T‐cell lymphocytosis, and PCR for antigen receptor rearrangement revealed a clonal expansion of the T‐cell receptor gamma chain genes. A clinical diagnosis of chronic lymphocytic leukemia (CLL) was made, and follow‐up was recommended. On Day 48 post‐presentation, the CBC showed mild non‐regenerative anemia (NRA), moderate leucocytosis due to moderate to marked lymphocytosis, basophilia, and a marked increase in hyposegmented neutrophils with mild toxic change in the absence of neutrophilia or neutropenia. Treatment with chlorambucil and prednisolone was initiated. On Days 87 and 197 post‐presentation, the CBC showed mild NRA, with progressively decreasing numbers of hyposegmented neutrophils. The dog remained without clinical signs. Basophilia and probable pseudo‐Pelger–Huët anomaly were possibly secondary to CLL. To the authors' knowledge, this is the first report of these two hematologic conditions secondary to CLL in dogs. Recognition of a pseudo‐Pelger–Huët anomaly is clinically relevant to avoid misinterpretation as a marked left shift due to severe inflammation and prevent unnecessary urgent therapeutic actions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Presumed pseudo‐Pelger–Huët anomaly and basophilia secondary to chronic lymphocytic leukemia in a dog

Martínez‐Caro,

Agulla,

Viñeta

et al. 2024

Veterinary Clinical Pathol

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“…Pelger‐Huët anomaly is most common among Australian Shepherds, although it can occur in a variety of other breeds and mixed‐breed dogs 1 . This anomaly has also been noted in cats, rabbits, horses, humans, and mice 2 …”

Section: Figurementioning

confidence: 99%