Neutrophil Function in an Inflammatory Milieu of Rheumatoid Arthritis

Chen, Weiqian; Wang, Qin; Ke, Yini; Lin, Jin

doi:10.1155/2018/8549329

Cited by 59 publications

(39 citation statements)

References 97 publications

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“…Currently, serveral studies indicated that multiple immune cells were involved in the development of arthritis. For example, neutrophil could be enrolled in the site of inflammation and play an important role in the disease [11]. In RA patients, 90% of cells in the synovial fluid are neutrophils [19].…”

Section: Discussionmentioning

confidence: 99%

“…The changes in immune cells after C.sinensis infection in CIA mice Current studies indicated that neutrophils, monocytes, T cells, and B cells, can be attracted and quickly recruited into the sites of infection, and play essential roles in rheumatoid arthritis [11,12]. In the study, we assessed whether C.sinensis infection could affect these immune cells in CIA mice.…”

Section: Csinensis Infection Alters the Humoral Immune Response In Cmentioning

confidence: 99%

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The impact of Clonorchis sinensis infection on immune response in mice with type II collagen-induced arthritis

Yang

Qin

et al. 2020

BMC Immunol

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Background: Clonorchis sinensis infection could trigger strong immune responses in mice and humans. However, whether the C.sinensis infection has an impact on arthritis is unknown. Here we investigated the effect of C.sinensis infection on type II collagen-induced arthritis in BALB/c mice. Results: The mice were firstly infected with 45 C.sinensis metacercariae by oral gavage. Four weeks later, arthritis in mice was induced by type II collagen. Joint inflammation with severe redness and swelling in hind paws was observed in type II collagen-induced arthritis (CIA) mice. Besides, the physical activity was significantly reduced, but the respiratory exchange ratio was increased in CIA mice. Compared with CIA mice, C.sinensis infection could increase the severity of arthritis in CIA mice, based on the results of disease score and pathological changes. Compared to CIA mice, increased neutrophils and Ly6C hi monocytes, decreased B cells and CD4 + T cells, were found in C.sinensis infected CIA mice. Besides these, C.sinensis infected mice also displayed significantly higher levels of serum IL-4 and IL-17 than those in CIA mice. Conclusions: Taken together, our data suggest that C.sinensis infection have a bad effect on arthritis, and could induce the abnormality of the immune response in mice with CIA.

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Section: Discussionmentioning

confidence: 99%

Section: Csinensis Infection Alters the Humoral Immune Response In Cmentioning

confidence: 99%

The impact of Clonorchis sinensis infection on immune response in mice with type II collagen-induced arthritis

Yang

Qin

et al. 2020

BMC Immunol

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“…Increased NET formation is observed in autoimmune diseases such as systemic lupus erythematosus and RA, where NETs can contribute to autoimmunity by exposing autoantigens, stimulating the inflammasome and activating complement . NETs contribute to the production of autoantibodies against citrullinated proteins in RA . NET release from neutrophils is emerging as an important factor in thrombogenesis, so‐called immunothrombosis, which takes place in sepsis (ie disseminated intravascular coagulation) and malignancy .…”

Section: Introductionmentioning

confidence: 99%

NETs analysed by novel calprotectin‐based assays in blood donors and patients with multiple myeloma or rheumatoid arthritis: A pilot study

Fagerhol

Johnson

Tangen³

et al. 2020

Scand J Immunol

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Two novel enzyme‐linked immunosorbent assays (ELISAs), designed to detect complexes containing DNA, leucocyte calprotectin and S100A12 proteins, were generated for improved specificity and rapid measurement of neutrophil extracellular traps (NETs). The assays were applied on plasma and serum samples from blood donors for establishment of reference values, and from patients with multiple myeloma (MM) or rheumatoid arthritis (RA) in order to examine putatively increased values in the two different inflammatory conditions. Although NETs were hardly detectable in healthy individuals, NET levels were as expected highly and statistically significantly increased in RA patients. The detection of statistically significantly increased NET levels in MM is a novel finding.

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“…The presence of hyperactive neutrophils in RA synovial fluid and pannus tissue, in particular NETosis (formation of neutrophil extracellular traps or NETs), has been confirmed by multiple studies. [198][199][200] NETs are chromatin-derived extracellular snares that are externalized from neutrophils in response to microbial infections or inflammation. 201 Neutrophils and NETosis are key components in the perpetual inflammatory response encountered in RA patients.…”

Section: Neutrophils and Netosismentioning

confidence: 99%

The Central Role of Acute Phase Proteins in Rheumatoid Arthritis: Involvement in Disease Autoimmunity, Inflammatory Responses, and the Heightened Risk of Cardiovascular Disease

Bezuidenhout

Pretorius

2020

Semin Thromb Hemost

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Rheumatoid arthritis (RA) is an autoimmune disease of complex etiopathogenic origin and traditionally characterized by chronic synovitis and articular erosions. Furthermore, there is strong evidence that infectious agents, including those that become dormant within the host, play a major role in much of the etiology of RA and its hallmark of inflammation. A combination of genetic predisposition, environmental exposure, and presence of infectious agents may therefore lead to a loss of immune tolerance to citrullinated proteins, which present as self-antigens to the human immune system. This results in generation of highly RA-specific autoantibodies, known as anti-citrullinated protein antibodies (ACPAs). Protein citrullination occurs via posttranslational deamination of arginine residues by peptidylarginine deiminase enzymes, which have confirmed sources of both endogenous and infectious origins. A recognized plasma protein target of citrullination and RA autoantibody generation is fibrin and its soluble precursor fibrinogen, both key components of hemostasis and acute phase reaction. Increased titers of ACPAs that accompany rapid progression to clinical RA disease have been shown to drive a variety of proinflammatory processes, and therefore results in aberrant fibrin clot formation and increased cardiovascular risk. However, the full extent to which hemostasis is affected in RA remains controversial, owing to the differential impact that citrullinated fibrin(ogen) and concurrent systemic inflammation may have on resulting hemostatic outcome. This review highlights key events in initiation of autoimmune-driven inflammatory events, including the role of bacterial infectious agents, which subsequently result in clinical RA disease and associated secondary cardiovascular disease risk, with specific focus on plasma proteins that are heavily involved throughout the immunopathological progression process.

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Neutrophil Function in an Inflammatory Milieu of Rheumatoid Arthritis

Cited by 59 publications

References 97 publications

The impact of Clonorchis sinensis infection on immune response in mice with type II collagen-induced arthritis

The impact of Clonorchis sinensis infection on immune response in mice with type II collagen-induced arthritis

NETs analysed by novel calprotectin‐based assays in blood donors and patients with multiple myeloma or rheumatoid arthritis: A pilot study

The Central Role of Acute Phase Proteins in Rheumatoid Arthritis: Involvement in Disease Autoimmunity, Inflammatory Responses, and the Heightened Risk of Cardiovascular Disease

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