Neutrophil Function in Elderly Persons Assessed by Flow Cytometry

Esparza, B.; Sánchez, H Catalina Salinas; Ruiz, Margaret; Barranquero, M.; Sabino, Ester C.; Merino, Fernando

doi:10.3109/08820139609059301

Cited by 64 publications

(52 citation statements)

References 30 publications

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“…Research to date suggests that any age-related decline in neutrophil function in healthy elderly individuals is largely due to a decline in phagocytic capacity, because chemotaxis remains largely unaltered in the elderly (MacGregor & Shalit, 1990) and similar data have been obtained for superoxide production in response to fMLP (Esparza et al, 1996;Butcher et al, 2001). Studies measuring phagocytosis of opsonized bacteria or yeast and opsonized zymosan as the neutrophil target have all shown a significant reduction in phagocytic ability in the elderly (Emanuelli et al, 1986;Mege et al, 1988;Esparza et al, 1996;Wenisch et al, 2000;Butcher et al, 2001). We have shown that one of the receptors involved in recognizing antibodies on the surface of bacteria, CD16, is significantly reduced with age and may contribute to the observed decline in neutrophil phagocytic function with age (Butcher et al, 2001).…”

Section: Effect Of Age On Adrenal Hormones and Immune Functionmentioning

confidence: 55%

Stress responses and innate immunity: aging as a contributory factor

2004

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SummaryEvolutionary pressure has selected individuals with traits that allow them to survive to reproduction, without consideration of the consequences for the post-child rearing years and old age. In the 21st century, society is populated increasingly by the elderly and with the falling birth rate and improved health care this trend is set to continue for the foreseeable future. To minimize the potential burden on health services one would hope that 'growing old gracefully' should also mean 'growing old healthily'. However, for too many the aging process is accompanied by increasing physical and mental frailty producing an elevated risk of physical and psychological stress in old age. Stress is a potent modulator of immune function, which in youth can be compensated for by the presence of an optimal immune response. In the elderly the immune response is blunted as a result of the decline in several components of the immune system (immune senescence) and a shifting to a chronic pro-inflammatory status (the so-called 'inflammaging' effect). We discuss here what is known of the effects of both stress and aging upon the innate immune system, focusing in particular upon the age-related alterations in the hypopituitary-adrenal axis. We propose a double hit model for age and stress in which the age-related increase in the cortisol/sulphated dehydroepiandrosterone ratio synergizes with elevated cortisol during stress to reduce immunity in the elderly significantly.

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Section: Effect Of Age On Adrenal Hormones and Immune Functionmentioning

confidence: 55%

Stress responses and innate immunity: aging as a contributory factor

2004

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“…Elderly people are more susceptible to infection with various pathogenic organisms than middle-aged or young adults because T-lymphocyte production and proliferation decline with age, resulting in decreased cell-mediated immunity and decreased antibody production to new antigens [30][31][32][33][34]. Additionally, their cardiopulmonary reverse is limited.…”

Section: Discussionmentioning

confidence: 99%

Endoscopic submucosal dissection with a combination of small-caliber-tip transparent hood and flex knife for superficial esophageal neoplasia. Is it safe for elderly patients?

et al. 2010

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“…16,17 Also, reduced phagocytosis has been described in subjects >65 years. 18 Little is known about phagocyte function in stroke, but there are hints that it may also be disturbed. One study reported impaired neutrophil burst in a small cohort of patients with intracranial hemorrhage who required neurosurgical intervention, 19 whereas an earlier report suggested the occurrence of alterations in neutrophil function in patients with stroke, as indicated by measurement of the granulocyte antisedimentation rate.…”

mentioning

confidence: 99%

Stroke Alters Respiratory Burst in Neutrophils and Monocytes

Ruhnau

Schulze

Gaida

et al. 2014

Stroke

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Background and Purpose— Stroke-induced immune alterations predispose patients to infections. Although the relationship between stroke and the adaptive immune system has been investigated in detail, to date it is unknown whether the innate immune system, which forms the first line of antibacterial defense, is also impaired in patients with stroke. Therefore, we investigated whether chemotaxis, phagocytosis, oxidative burst, degranulation of defensins, and NETosis in monocytes and in neutrophil granulocytes are altered in patients with stroke compared with controls. Methods— Sixty-three patients having acute ischemic stroke were recruited within 12 hours of symptom onset; blood was sampled on admission and on days 1, 3, 5, and 7. Thirty-seven age-matched controls were also recruited. Cell migration, phagocytosis, and oxidative burst of phagocytes were determined in vitro. Human neutrophil peptides 1 to 3 and serum metanephrine levels were measured by enzyme-linked immunosorbent assay, and NETosis was quantified by immunohistochemistry. Results— The key mechanisms required for bacterial killing, oxidative burst, and NETosis were significantly reduced in samples taken from patients with stroke compared with controls, whereas migration, phagocytic function, and defensin production remained unimpaired in monocytes and granulocytes from patients with stroke. Conclusions— Stroke-induced immune alterations include impairment of the first-line defense performed by specialized phagocytes against bacteria. The hypothesis that these changes enhance susceptibility to acquired infections is supported by our observation that on admission oxidative burst in monocytes was more impaired in patients with stroke with subsequent stroke-associated infections.

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Neutrophil Function in Elderly Persons Assessed by Flow Cytometry

Cited by 64 publications

References 30 publications

Stress responses and innate immunity: aging as a contributory factor

Stress responses and innate immunity: aging as a contributory factor

Endoscopic submucosal dissection with a combination of small-caliber-tip transparent hood and flex knife for superficial esophageal neoplasia. Is it safe for elderly patients?

Stroke Alters Respiratory Burst in Neutrophils and Monocytes

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