Neutrophil function in lymphoreticular malignancy

Hancock, B. W.; Bruce, Lesley J.; Richmond, John C.

doi:10.1038/bjc.1976.80

Cited by 15 publications

(12 citation statements)

References 10 publications

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“…This result confirms the finding of Sbarra (1964) but contradicts that of Steigbigel et al (1976) andHancock et al (1976), who found normal bactericidal activity. This discrepancy may be partly due to technical factors, since, in the experiments of Steigbigel et al, the tests were carried out using longer incubation with bacteria, and delay in phagocytosis and killing would not have been detected.…”

Section: Idiscussionsupporting

confidence: 82%

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Neutrophil function during chemotherapy for Hodgkin's disease

Gandossini¹,

Souhami²,

Babbage³

et al. 1981

Br J Cancer

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Summary.-Simultaneous measurement of neutrophil migration, phagocytic activity, candidacidal and bactericidal activity were made during quadruple chemotherapy of advanced Hodgkin's disease (HD). Measurements were also made in normal individuals, hospital patients not on chemotherapy, untreated patients with advanced HD and patients off chemotherapy for over a year.Neutrophil migratory activity was usually normal in untreated HD patients and those on chemotherapy, but > 200O of all tests showed depressed values, some of which were corrected by plasma. Similar results were found with neutrophil phagocytosis. Abnormalities in these functions were found in both early and late cycles, but there was a tendency for migration to deteriorate during later chemotherapy cycles. Neutrophil candidacidal and bactericidal activity were frequently depressed in patients on treatment and there was deterioration in candidacidal activity during the chemotherapy cycle. These abnormalities of killing activity were frequently corrected in control plasma.Neutrophil function is normal in most patients with advanced HD and in patients in remission. In a minority of patients on treatment there are marked functional defects, especially in killing activity. These defects are partly cell-associated and partly plasma-related. Susceptibility to infection during chemotherapy of HD may be partly due to defective neutrophil function.

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Section: Idiscussionsupporting

confidence: 82%

“…disease and of treatment. Results have therefore been conflicting; neutrophil microbial-killing activity for example being reported as depressed (Lehrer & Cline, 1971) or normal (Steigbigel et al, 1976;Hancock et al, 1976).…”

mentioning

confidence: 99%

Neutrophil function during chemotherapy for Hodgkin's disease

Gandossini¹,

Souhami²,

Babbage³

et al. 1981

Br J Cancer

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“…6 and Steigbigel et al23 found these neutrophil functions to be essentially normal or enhanced in patients with lymphoreticular malignancies. Lehrer and Clines also reported neutrophil phagocytic and candidacidal activity to be normal in patients with lymphoma and Stages I, 11, and I11 Hodgkin's disease.…”

Section: Cancer September 1979mentioning

confidence: 95%

Neutrophil function in lymphoreticular malignancy

McCormack

Nelson

Bloomfield

et al. 1979

Cancer

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Neutrophil chemotaxis, phagocytosis, and metabolic stimulation were studied in 25 patients with untreated lymphoreticular malignancies, 8 patients with untreated carcinomas, and 8 patients undergoing therapy for lymphoreticular tumors. Phagocytic activity and metabolic stimulation during phagocytosis were comparable to controls in all patient groups. Slight, but significant, differences were found in chemotactic responsiveness of untreated patient groups when compared to controls. In almost all instances, chemotactic responsiveness reverted to normal in most patients studied after therapy for the malignant process. In patients with intact immunologic function these minor differences in chemotactic responsiveness are probably not sufficient to predispose to infection. However, this defect could be additive, and when present in combination with impaired immunity may contribute to compromised host defense.Cancer 44:920-926, 1979.

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“…It is worth noting that leucocyte alkaline phosphatase (LAP) activity was also found to be decreased in patients with solid tumours who had no evidence of disease when studied (Lokich, 1977). An enhanced spontaneous NBT reduction and phagocyte killing capacity has been frequently reported in patients with lymphoma (Silverman and Reed, 1973;Chang et al, 1974;Hancock et al, 1976;Steigbigel et al, 1976). In our study, the capacity of reduction in these cases was comparable to that in healthy controls and markedly higher than in patients with other solid tumours.…”

Section: Discussionmentioning

confidence: 92%

Comparative study of the endotoxin-stimulated nitroblue tetrazolium test in disease and health.

Haim¹,

Obedeanu²,

Meshulam³

et al. 1978

J Clin Pathol

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SUMMARY Endotoxin-stimulated nitroblue tetrazolium (NBT) reduction was evaluated in 853 individuals: 270 healthy controls, 334 with various non-neoplastic conditions, 220 with solid non-lymphomatous tumours, and 29 with lymphoma. Each of the above groups was divided into three age subgroups: < 60, 60-69, and > 70 years.In the controls and in patients with nonmalignant diseases, significantly lower values were recorded for elderly subjects (. 60 years) compared with younger subjects of the same group, whereas in cancer patients the results were independent of age. Under the age of 60, stimulated values for both patient groups were significantly lower than the control values, and in patients with solid non-lymphomatous tumours significantly lower values were attained than in the other patients. NBT reduction in lymphoma patients was comparable to that of the controls. In the elderly (age > 70) no significant differences were noted between patients and controls.It is suggested that stimulated NBT reduction declines with advancing age. While this test clearly demonstrates some leucocyte dysfunction in solid cancer, its value in investigating neutrophil behaviour in elderly subjects is questioned.According to recent observations made in our laboratory, peripheral polymorphonuclear leucocytes (PMNs) from patients with solid cancer have a diminished capacity to reduce nitroblue tetrazolium (NBT) dye to formazan when maximally stimulated with endotoxin (Haim et al., 1977a(Haim et al., , 1977b

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Neutrophil function in lymphoreticular malignancy

Cited by 15 publications

References 10 publications

Neutrophil function during chemotherapy for Hodgkin's disease

Neutrophil function during chemotherapy for Hodgkin's disease

Neutrophil function in lymphoreticular malignancy

Comparative study of the endotoxin-stimulated nitroblue tetrazolium test in disease and health.

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