Neutrophil gelatinase-associated lipocalin as a prognostic biomarker of severe acute respiratory distress syndrome

Son, Eunjeong; Cho, Woo Hyun; Jang, Jin Ho; Kim, Tae-Hwa; Jeon, Doosoo; Kim, Yun Seong; Yeo, Hye Ju

doi:10.1038/s41598-022-12117-4

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…Additionally, LCN2 has been shown to induce antioxidants in vitro [ 17 ]. Elevated LCN2 expression has been observed in patients with chronic obstructive pulmonary disease and acute respiratory distress syndrome, which have been associated with increased oxidative stress levels [ 18 – 20 ]. Moreover, Ikezoe et al reported that patients with IPF had higher LCN2 levels in bronchoalveolar lavage fluid (BALF) than those with other interstitial pneumonia [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Lipocalin-2 as a prognostic marker in patients with acute exacerbation of idiopathic pulmonary fibrosis

Tanahashi,

Iwamoto,

Yamaguchi

et al. 2024

Respir Res

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Background Lipocalin-2 (LCN2) is a secretory glycoprotein upregulated by oxidative stress; moreover, patients with idiopathic pulmonary fibrosis (IPF) have shown increased LCN2 levels in bronchoalveolar lavage fluid (BALF). This study aimed to determine whether circulatory LCN2 could be a systemic biomarker in patients with IPF and to investigate the role of LCN2 in a bleomycin-induced lung injury mouse model. Methods We measured serum LCN2 levels in 99 patients with stable IPF, 27 patients with acute exacerbation (AE) of IPF, 51 patients with chronic hypersensitivity pneumonitis, and 67 healthy controls. Further, LCN2 expression in lung tissue was evaluated in a bleomycin-induced lung injury mouse model, and the role of LCN2 was investigated using LCN2-knockout (LCN2 -/-) mice. Results Serum levels of LCN2 were significantly higher in patients with AE-IPF than in the other groups. The multivariate Cox proportional hazards model showed that elevated serum LCN2 level was an independent predictor of poor survival in patients with AE-IPF. In the bleomycin-induced lung injury mouse model, a higher dose of bleomycin resulted in higher LCN2 levels and shorter survival. Bleomycin-treated LCN2 -/- mice exhibited increased BALF cell and protein levels as well as hydroxyproline content. Moreover, compared with wild-type mice, LCN2-/- mice showed higher levels of circulatory 8-isoprostane as well as lower Nrf-2, GCLC, and NQO1 expression levels in lung tissue following bleomycin administration. Conclusions Our findings demonstrate that serum LCN2 might be a potential prognostic marker of AE-IPF. Moreover, LCN2 expression levels may reflect the severity of lung injury, and LCN2 may be a protective factor against bleomycin-induced acute lung injury and oxidative stress.

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Section: Introductionmentioning

confidence: 99%

Lipocalin-2 as a prognostic marker in patients with acute exacerbation of idiopathic pulmonary fibrosis

Tanahashi,

Iwamoto,

Yamaguchi

et al. 2024

Respir Res

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“…Considering that lung injury can occur during COVID-19, it is significant that lung epithelial damage is associated with elevated serum NGAL (sNGAL) levels. It was demonstrated that increased sNGAL can be a biomarker of pulmonary injuries in mechanically ventilated patients and can be associated with early mortality in patients with ARDS [13,14]. Physiologically, NGAL is present in the bloodstream at very low levels, which can increase significantly in the event of ischemic or toxic injury.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil Gelatinase-Associated Lipocalin as a Biomarker in Post-Acute COVID-19 Syndrome

Żmudka,

Gałeczka-Turkiewicz,

Wroniecka

et al. 2024

JCM

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Background: Neutrophil gelatinase-associated lipocalin (NGAL) is part of the innate immune system and acute-phase protein. Current data state that acute COVID-19 patients have higher levels of serum NGAL (sNGAL), but it is not known if higher protein levels are maintained in the convalescents. As post-COVID complications are currently the most important aspect of the disease, further research into metabolic and immunological consequences of the disease is needed. Methods: We aimed to determine the levels of sNGAL in a patient population 3 months after the acute phase of the disease and to identify the factors that may be related to the elevation of sNGAL levels in the mentioned cohort. The study included 146 patients diagnosed with COVID-19 in different stages of the disease. Three months after COVID-19 diagnosis, patients’ sera were sampled and tested. Results: We demonstrate an association between the severity of the disease in the acute phase and elevated sNGAL levels three months after recovery, with the exception of the most severe hospitalized patients, who received early treatment. Moreover, we establish that sNGAL levels could be associated with prolonged dyspnea and the regulation of hunger and satiety in COVID-19 convalescents. Conclusions: These observations support the view that the introduction of antiviral treatment, steroids, and intense oxygen therapy reduces post-COVID immune-associated complications.

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“…ALI is a common clinical syndrome that often results in acute respiratory failure [17], typically characterized by severe pulmonary edema and uncontrolled inflammation of the lungs [18]. The inflammatory response and pulmonary edema can rapidly deteriorate lung function, which may ultimately result in respiratory failure and multiple organ dysfunction syndrome [19,20]. Inflammation and oxidative stress are the primary triggers of ALI development [21].…”

Section: Introductionmentioning

confidence: 99%

Preventive Effect of Arctium lappa Polysaccharides on Acute Lung Injury through Anti-Inflammatory and Antioxidant Activities

Lu,

Wei,

Gong

et al. 2023

Nutrients

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The objective of this study was to investigate the preventive effects of polysaccharides extracted from the roots of Arctium lappa (ALP) against acute lung injury (ALI) models induced by lipopolysaccharide (LPS). The polysaccharides were extracted and characterized, and their anti-inflammatory and antioxidant capacities were assessed. The findings demonstrated that ALP could mitigate the infiltration of inflammatory cells and reduce alveolar collapse in LPS-induced ALI in mice. The expression levels of the pro-inflammatory factor TNF-α decreased, while the anti-inflammatory factor IL-10 increased. Furthermore, the administration of ALP improved the activities of lung antioxidant enzymes, including SOD, GSH, and CAT, and lowered MDA levels. These results suggest that ALP exhibits a preventive effect on ALI and has potential as an alternative treatment for lung injury.

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Neutrophil gelatinase-associated lipocalin as a prognostic biomarker of severe acute respiratory distress syndrome

Cited by 4 publications

References 22 publications

Lipocalin-2 as a prognostic marker in patients with acute exacerbation of idiopathic pulmonary fibrosis

Lipocalin-2 as a prognostic marker in patients with acute exacerbation of idiopathic pulmonary fibrosis

Neutrophil Gelatinase-Associated Lipocalin as a Biomarker in Post-Acute COVID-19 Syndrome

Preventive Effect of Arctium lappa Polysaccharides on Acute Lung Injury through Anti-Inflammatory and Antioxidant Activities

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