Neutrophil gelatinase-associated lipocalin in peritoneal dialysis reflects status of peritoneum

Lacquaniti, Antonio; Chirico, Valeria; Mondello, Stefania; Buemi, Antoine; Lupica, Rosaria; Fazio, Maria Rosaria; Buemi, Michele; Aloisi, Carmela

doi:10.5301/jn.5000271

Cited by 9 publications

(7 citation statements)

References 28 publications

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“…Expansion of peritoneal vasculature and augmented vessel permeability are important determinants of increased small solute transport across the peritoneal membrane and UF failure [7]. Chronic inflammation can increase the peritoneal NGAL [8]. Many other factors may also affect the peritoneal NGAL level, such as peritoneal mesothelial cell's function, serum NGAL, residual renal function [3].…”

Section: Discussionmentioning

confidence: 99%

Untitled

2021

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Section: Discussionmentioning

confidence: 99%

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2021

AJBSR

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“…However, there is a paucity of data available directly concerning its meaning in the diagnosis of peritonitis (14,15). Axelsson et al enrolled patients not in PD with peritonitis recovered in the surgery department (14), whereas Leung et al ‘s study and Lacquaniti et al ‘s study were based on only 27 and 30 PD patients (15,16). Finally, we had previously reported on 30 PD patients demonstrating that NGAL had great performance in the diagnosis of peritonitis (17).…”

Section: Discussionmentioning

confidence: 99%

“…However, there is a paucity of data available directly concerning its meaning in the diagnosis of peritonitis (14,15 (15,16). Finally, we had previously reported on 30 PD patients demonstrating that NGAL had great performance in the diagnosis of peritonitis (17).…”

Section: Discussionmentioning

confidence: 99%

“…Specifically, Axelsson et al demonstrated severe acute peritonitis was accompanied by an increase of NGAL levels in plasma and in peritoneal exudates (14). Similarly, 2 studies reported an increase of NGAL levels in PDE during peritonitis (15,16). Finally, in a preliminary study, we reported NGAL levels in peritoneal effluent (peritoneal NGAL) as a putative indicator for the early diagnosis of peritonitis (17).…”

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The Role of NGAL in Peritoneal Dialysis Effluent in Early Diagnosis of Peritonitis: Case-Control Study in Peritoneal Dialysis Patients

et al. 2015

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♦ Background: Peritoneal dialysis (PD) is frequently complicated by high rates of peritonitis, which result in hospitalization, technique failure, transfer to hemodialysis, and increased mortality. Early diagnosis, and identification of contributing factors are essential components to increasing effectiveness of care. In previous reports, neutrophil gelatinase-associated lipocalin (NGAL), a lipocalin which is a key player in innate immunity and rapidly detectable in peritoneal dialysis effluent (PDE), has been demonstrated to be a useful tool in the early diagnosis of peritonitis. This study investigates predictive value of PDE NGAL concentration as a prognostic indicator for PD-related peritonitis.

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“…Furthermore, peritoneal inflammation can also increase dialysate NGAL level in peritonitis patients due to overproduction by mesothelial cells and neutrocyte [4]. It is reported that neutrophil gelatinase-associated lipocalin in peritoneal dialysis could reflects status of peritoneum [5], as evidenced by an inverse correlation between dialysate NGAL and peritoneal ultrafiltration volume [3].…”

Section: Introductionmentioning

confidence: 99%

The Ratio of Dialysate NGAL to Plasm NGAL (NGAL D/P) Can Reflect Peritoneal Transport in CAPD Patients

Wen

2021

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Objectives: To probe the role of peritoneal NGAL in reflecting peritoneum function.Methods: 20 CAPD anuria patients without peritonitis in our peritoneal dialysis center were recruited from July 2016 to July 2018. These patients were divided into high-transport peritoneum group and non-high transport peritoneum group according to peritoneal transport type. Patients from both groups received the same dialysis solutions and dialysis modality. Peritoneal transport type, serum C-reactive protein, peritoneal equilibrium test results, dialysate NGAL, plasm NGAL, the ratio of dialysate NGAL to plasm NGAL (D/P NGAL) from both groups were recorded. Spearman's correlation coefficient was employed to examine the relations between variables. Receiver operating characteristic (ROC) curve analysis was used to calculate the area under the curve (AUC) for ratio of dialysate NGAL to plasm NGAL (D/P NGAL) and peritoneal creatinine to serum creatinine (D/P creatinine).Results: we had recruited 20 patients (11 male and 9 female, 7 high transport and 13 non-high transport group,). D/P NGAL had a correlation with D/P creatinine in CAPD patients (p < 0.05). The area under the ROC curve for D/P NGAL was 0.81. Conclusion:The ratio of dialysate NGAL to plasm NGAL (D/P NGAL) can reflect peritoneal transport in CAPD patients.

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Neutrophil gelatinase-associated lipocalin in peritoneal dialysis reflects status of peritoneum

Abstract: Mesothelial cells have an active role in the structural and functional alteration of the peritoneum during PD, and NGAL represents a valid biomarker for peritoneum evaluation.

Cited by 9 publications

References 28 publications

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The Role of NGAL in Peritoneal Dialysis Effluent in Early Diagnosis of Peritonitis: Case-Control Study in Peritoneal Dialysis Patients

The Ratio of Dialysate NGAL to Plasm NGAL (NGAL D/P) Can Reflect Peritoneal Transport in CAPD Patients

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