Neutrophil gelatinase-associated lipocalin (NGAL) for the early detection of contrast-induced nephropathy after percutaneous coronary intervention

Liebetrau, Christoph; Gaede, Luise; Doerr, Oliver; Blumenstein, Johannes; Rixe, Johannes; Teichert, Olaf; Willmer, Matthias; Weber, Michael A.; Rolf, Andreas; Möllmann, Helge; Hamm, Christian W.; Nef, Holger

doi:10.3109/00365513.2013.860615

Cited by 37 publications

(31 citation statements)

References 32 publications

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“…Despite published data demonstrating that urinary neutrophil gelatinase-associated lipocalin (U-NGAL) is a real-time marker [31], our result showed that there was a significant difference between the serum and urinary NGAL biomarker levels after administration of CP at a high dose of 50 mg/m 2 , which was seen at the highest range of NGAL gene expression at urinary; in agreement with this finding, Liebetrau et al suggested that the urinary NGAL as a marker of tubular damage depends on these parameters as well [32]. The present study demonstrated that U-NGAL compared with serum NGAL is a major biomarker for the early risk stratification of ACRI after CP chemotherapy and is superior to prognosis for the early detection of kidney injuries.…”

Section: Discussionsupporting

confidence: 93%

RETRACTED ARTICLE: The value of U-NGAL expression as a potential prognostic biomarker in patients with renal cancer after neoadjuvant chemotherapy with cisplatin

Ebrahimi¹,

Pirasteh

Rezakhaniha

et al. 2015

Tumor Biol.

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Urinary neutrophil gelatinase-associated lipocalin (U-NGAL) is assumed to be a highly sensitive and early particular factor of chronic kidney injury (CKI) in patients with kidney tumors after short-and long-term cisplatin (CP) chemotherapy. In this study, we evaluated events in serum/urine neutrophil gelatinase-associated lipocalin (NGAL) levels (ng/ mL, ELISA assay) at 1, 2, and 4 h and 2, 3, 4, 7, 10, 14, and 28 days after drug injection (50 mg/m 2 ) versus baseline in seven successive cases of solid kidney tumors with CKI and three consecutive controls without CKI. Furthermore, shortterm cisplatin chemotherapy (STC, 1 day) was compared to long-term (LTC, 28 days) treatment using plasma and urine NGAL. We found that CKI was associated with higher levels of serum NGAL (p<0.001) and urine NGAL (p<0.021) compared with exposed controls. Patients with CKI associated LTC had increased level of S-NGAL (p < 0.05) and U-NGAL (p<0.05) compared with CKI patients without cisplatin treatment. Our data suggest that U-NGAL may be considered to be reliable markers to monitor renal injury in CKI patients undergoing LTC and exposed to CP. In fact, elevation of U-NGAL was associated with a high cisplatin nephrotoxicity profile.

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Section: Discussionsupporting

confidence: 93%

RETRACTED ARTICLE: The value of U-NGAL expression as a potential prognostic biomarker in patients with renal cancer after neoadjuvant chemotherapy with cisplatin

Ebrahimi¹,

Pirasteh

Rezakhaniha

et al. 2015

Tumor Biol.

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“…In SHRs with CI-AKI, the area under the receiver operating characteristic curve (AUROC) value of NGAL is 0.73, which is accepted as a value of failure [6] . In contrast, in humans with CI-AKI, 4 of 8 studies showed an excellent value (0.93-1.0) [39][40][41][42] , 2 of 8 studies showed a good value of NGAL (0.83-0.84) [43,44], and 2 of 8 studies showed a poor value of NGAL (0.63-0.68) [29,45] . In CKD patients undergoing elective coronary angiography with contrast, postprocedural NGAL increases from baseline in each stage of CKD [46] .…”

Section: Similar Pathogenesis Of Ed and Asymmetric Dimethylarginine Imentioning

confidence: 93%

Aging Male Spontaneously Hypertensive Rat as an Animal Model for the Evaluation of the Interplay between Contrast-Induced Acute Kidney Injury and Cardiorenal Syndrome in Humans

Zhang

Fallahzadeh

McCullough³

2016

Cardiorenal Med

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Background:Although there are some animal models for biomarkers of contrast-induced acute kidney injury (CI-AKI), for cardiorenal syndrome (CRS) and for acute renal failure, the interplay between CI-AKI and CRS has yet to be evaluated. Insight into the pathogenesis of CRS is urgently needed from animal models in order to foster the discovery and implementation of novel biomarkers for this disease. Specially designed animal models for type 1 and 3 CRS, particularly CI-AKI, have not yet emerged. Summary: We hypothesize that the aging male spontaneously hypertensive rat (SHR) is likely to be a suitable model. The SHR model is able to mimic risk factors for preclinical CRS that appears in the clinical setting, specifically hypertension, age, preexisting damage and dysfunction of the heart and kidney, endothelial dysfunction, increased level of reactive oxygen species, decreased level and bioavailability of nitric oxide (NO), impairment of the L -arginine-NO pathway, and insulin resistance. In the SHR, CI-AKI results in a different profile of AKI biomarkers than is seen with preexisting chronic kidney injury. Key Messages: The SHR model can be used to evaluate the interaction between CI-AKI and CRS type 1 and 3 and to verify neutrophil gelatinase-associated lipocalin (NGAL) as a reliable CI-AKI biomarker for clinical application. Further research is warranted with a large number of aging male SHRs to prove NGAL as a sensitive, specific, highly predictive, early biomarker for CI-AKI.

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“…Haase et al (28) analyzed data from 191 patients in 3 studies and found that when urinary NGAL is measured within 6 hours after contrast medium administration, it has better sensitivity than serum creatinine alone for acute kidney injury detection. Moreover, recent studies and a meta-analysis have demonstrated the role of serum and urinary NGAL in the prediction of CIN (15,16,(29)(30)(31)(32)(33)(34)(35)(36) and, although this biomarker has also been reported to have a low sensitivity in predicting CIN in specific settings, such as ACS (37), a previous study also suggested that it can also predict the severity of CIN (38).…”

Section: Discussionmentioning

confidence: 99%

Cystatin C, but not urinary or serum NGAL, may be associated with contrast induced nephropathy after

Cecchi

Avveduto

DʼAlfonso

et al. 2017

AMA

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Neutrophil gelatinase-associated lipocalin (NGAL) for the early detection of contrast-induced nephropathy after percutaneous coronary intervention

Abstract: Urinary NGAL is a biomarker for predicting CI-AKI when measured 1 day after PCI.

Cited by 37 publications

References 32 publications

RETRACTED ARTICLE: The value of U-NGAL expression as a potential prognostic biomarker in patients with renal cancer after neoadjuvant chemotherapy with cisplatin

RETRACTED ARTICLE: The value of U-NGAL expression as a potential prognostic biomarker in patients with renal cancer after neoadjuvant chemotherapy with cisplatin

Aging Male Spontaneously Hypertensive Rat as an Animal Model for the Evaluation of the Interplay between Contrast-Induced Acute Kidney Injury and Cardiorenal Syndrome in Humans

Cystatin C, but not urinary or serum NGAL, may be associated with contrast induced nephropathy after

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