Neutrophil granulocytes as host cells and transport vehicles for intracellular pathogens: Apoptosis as infection-promoting factor

Laskay, Tamás; Zandbergen, Ger van; Solbach, Werner

doi:10.1016/j.imbio.2007.11.010

Cited by 138 publications

(137 citation statements)

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“…At the 5 mg/mL concentration, the observed percentages of fluorescence positivities were 17.5 ± 0.412% and 5.6 ± 0.316% (mean ± SD), for untreated PMNLs and PMA-stimulated PMNLs, respectively. enzymes (such as elastase) to destroy microorganisms (Laskay et al, 2008). ROS and elastase are involved in the pathogenesis of several diseases and tissue damage processes (Paula et al, 2009;Derochette et al, 2013).…”

Section: Pmn Elastase Activity By Flow Cytometric Rgeselastase Testmentioning

confidence: 99%

“…Polymorphonuclear leukocytes (PMNLs) (neutrophils) are a class of white blood cells that play an important role in an organism's defense against infectious agents such as microorganisms, virally infected cells, and tumor cells (Lorenzen et al, 2000;Laskay et al, 2008;Paula et al, 2009). Once an inflammatory response is initiated, neutrophils are activated and recruited to the sites of infection to ingest and destroy infectious agents by phagocytosis.…”

Section: Introductıonmentioning

confidence: 99%

“…Once an inflammatory response is initiated, neutrophils are activated and recruited to the sites of infection to ingest and destroy infectious agents by phagocytosis. Activated neutrophils use both oxygen-dependent and oxygenindependent mechanisms to kill microorganisms (Laskay et al, 2008).…”

Section: Introductıonmentioning

confidence: 99%

“…In the oxygen independent killing mechanism, primary (azurophilic) granules of neutrophils release their proteolytic enzymes, such as elastase and cathepsins, and bactericidal proteins in phagolysosomes to digest phagocytized microorganisms (Laskay et al, 2008). Proteolytic enzymes secreted by neutrophils contribute to the regulation of innate immunity, inflammation, and infection, and degrade the extracellular matrix components (Paula et al, 2009).…”

Section: Introductıonmentioning

confidence: 99%

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Effects of Turkish propolis extract on secretion of polymorphonuclear elastase following respiratory burst

Barlak¹,

Uçar²,

Cakıroglu³

2015

Turk J Biol

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Section: Pmn Elastase Activity By Flow Cytometric Rgeselastase Testmentioning

confidence: 99%

Section: Introductıonmentioning

confidence: 99%

Section: Introductıonmentioning

confidence: 99%

Section: Introductıonmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Turkish propolis extract on secretion of polymorphonuclear elastase following respiratory burst

Barlak¹,

Uçar²,

Cakıroglu³

2015

Turk J Biol

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“…In case of the infection with extracellular pathogens, programmed death of neutrophil granulocytes has a protective impact, targeting to the elimination of the pathogen and restoration of cellular homeostasis of the organism. Intracellular pathogens use the apoptosis of the infected neutrophils to their advantage as the protection against the immune defenses of the organism, causing further advancement of the pathological process and its transformation into the chronic form [9,68,69].…”

Section: Influence Of Bacteria Viruses and Fungi On The Neutrophil Amentioning

confidence: 99%

The Role of Neutr Ophils and Their Apoptosis in There Solution of Inflammation

Pavlyshyn¹,

Sarapuk²

2015

PU-HSP

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puls Uczelni 2015 (9) 4Niniejszy materiał jest udostępniony na licencji creative commons -Uznanie autorstwa 4.0 pL.Pełne postanowienia tej licencji są dostępne na: http://creativecommons.org/licenses/by-nc-sa/4.0/legalcode Prace poglądowe | Reviews DOI: 10.5604/2081DOI: 10.5604/ -2021 tHe rOLe OF NeUtrOpHiLS AND tHeir ApOptOSiS iN tHe reSOLUtiON OF iNFLAMMAtiONRola granulocytów obojętnochłonnych i ich apoptozy w zwalczaniu stanu zapalnego A -przygotowanie projektu badania | study design, B -zbieranie danych | data collection, C -analiza statystyczna | statistical analysis, D -interpretacja danych | data interpretation, E -przygotowanie maszynopisu | manuscript preparation, F -opracowanie piśmiennictwa | literature search, G -pozyskanie funduszy | funds collection SUMMARY Inflammation, as a part of the body's immune response, is present in the progression of most diseases. Neutrophils form the first line of the defense against invading pathogens and subsequently play a prominent role in the resolution of inflammation.They have a protective function as they release antibacterial enzymes and generate reactive oxygen species. Neutrophils are able to regulate the inflammatory reaction by undergoing apoptosis. Apoptosis, then, facilitates cellular homeostasis ( immune defense), promotes the elimination of activated cells of the immune system, and can act as a major pathogenetic link of an inflammation process, defining its character. This review highlights the mechanisms of apoptosis, the influence of external and internal factors and infectious agents (viruses, extracellular and intracellular microorganisms) on the enactment of neutrophil programmed death and the resolution of inflammation. Keywords: neutrophils, apoptosis, inflammation STRESZCZENIEStan zapalny jako część odpowiedzi immunologicznej organizmu jest patologiczną podstawą większości chorób. Granulocyty obojętnochłonne tworzą pierwszą linię obrony przed inwazją patogenów i odgrywają znaczącą rolę w zwalczaniu stanu zapalnego. Realizują one funkcję ochronną poprzez uwalnianie enzymów przeciwbakteryjnych i wytwarzanie wolnych rodników. Granulocyty obojętnochłonne są w stanie regulować reakcję zapalną poprzez apoptozę. Apoptoza zapewnia homeostazę komórek, ochronę immunologiczną, nasila eliminację aktywowanych komórek układu odpornościowego oraz może stanowić znaczący związek patogenetyczny z procesem zapalnym, określając jego charakter. W artykule zwrócono uwagę na mechanizmy apoptozy, wpływ czynników zewnętrznych i wewnętrznych oraz czynników zakaźnych (wirusy, wewnątrzkomórkowe i zewnątrz-komórkowe mikroorganizmy) na realizację zaprogramowanej śmierci granulocytów obojętnochłonnych i zwalczanie stanu zapalnego.Słowa kluczowe: granulocyty obojętnochłonne, apoptoza, stan zapalny (PU-HSP 2015; 9, 4: 18-25)

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Leishmaniases

Chang¹

2012

Encyclopedia of Life Sciences

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Leishmaniases are parasitic diseases, which are transmitted by the blood‐sucking sand flies as the vectors. These diseases are largely zoonotic, but considered as anthroponotic in some endemic sites. The reservoir animals include canines, rodents, edentates and other wild animals. A spectrum of clinical manifestations is associated with these diseases, ranging from self‐healing cutaneous lesions to facial mucocutaneous disfiguration to visceralization with fatal consequence. According to the World Health Organisation, there are 12 million cases of these diseases in approximately 90 countries with an annual incidence of approximately 2 million. Treatment of leishmaniases depends on very few drugs for chemotherapy, which are either expensive or toxic and have lost effectiveness due to drug‐resistance. The causative agents are the trypanosomatid protozoa Leishmania , widespread in tropical and subtropical areas. Intraphagolysosomal parasitism of macrophages by these parasites is a key feature in considering molecular mechanisms of their virulence relevant to developing effective drugs and vaccines needed. Key Concepts: Trypanosomatid protozoa in the genus of Leishmania cause Leishmaniases. They have evolved mechanisms to live in macrophage endosomes/lysosomes. The diseases are wide‐spread mainly in tropical and subtropical areas of the world. The diseases are largely zoonotic and transmitted by blood‐sucking sand flies. Reservoirs include domestic and wild animals, for example, canines, rodents & edentates. Clinically, there are cutaneous, mucocutaneous and visceral Leishmaniasis. The clinical spectrum results from host immunopathology to Leishmania infection. Chemotherapy relies on toxic drugs and loses its effectiveness to drug‐resistance. Drug development programs by targeting unique parasite enzymes are very few. Control programs include the use of anti‐vector pesticide/repellents.

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Neutrophil granulocytes as host cells and transport vehicles for intracellular pathogens: Apoptosis as infection-promoting factor

Cited by 138 publications

References 61 publications

Effects of Turkish propolis extract on secretion of polymorphonuclear elastase following respiratory burst

Effects of Turkish propolis extract on secretion of polymorphonuclear elastase following respiratory burst

The Role of Neutr Ophils and Their Apoptosis in There Solution of Inflammation

Leishmaniases

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