Neutrophil infiltration leads to fetal growth restriction by impairing the placental vasculature in DENV-infected pregnant mice

Zhang, Yingying; Sheng, Ziyang; Chen, Qiaozhu; Zhou, Anni; Cao, Jin; Xue, Fei; Ye, Yanzhen; Wu, Na; Gao, Na; Fan, Dongying; Liu, Libo; Li, Yuetong; Wang, Peigang; Li, Liang; Zhou, Dujin; Zhang, Fuchun; Li, Fang; An, Jing

doi:10.1016/j.ebiom.2023.104739

Cited by 5 publications

(3 citation statements)

References 76 publications

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“…Many etiological factors have been identified in the pathogenesis of FGR, encompassing various pathways (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Among the most significant are inflammation, inadequate angiogenesis, and oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…It is associated with long-term complications such as metabolic syndrome, cardiovascular disease, and diabetes, as well as short-term complications like low birth weight, prematurity, neonatal exit, and a high number of neonates in the intensive care unit (1)(2)(3)(4). The pathogenesis is multifactorial, involving genetic factors, maternal inflammation, immune system abnormalities, infections, oxidative stress, defects in spiral artery remodeling, and endocrine causes (4)(5)(6)(7)(8)(9)(10)(11).…”

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confidence: 99%

“…It is well-known that inflammation plays a major role in tissue homeostasis (12). To prevent tissue rejection at the beginning of pregnancy, there is a physiological rearrangement of the innate immune system and cytokine network (6,7,11,12). Changes occur in the inflammatory and infectious balance, especially in the activity of T cells, with the goal of maintaining the fetomaternal relationship in balance.…”

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confidence: 99%

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The significance of Systemic Immune Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) in fetuses with fetal growth restriction

Ağaoğlu

2023

Acad J Health

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Objectives: Our aim was to investigate the significance of parameters such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune inflammatory index (SII), and systemic inflammatory response index (SIRI) in late fetal growth restriction (FGR) cases.Methods: After applying the exclusion criteria, 70 late FGR cases and 70 healthy pregnant cases matched by maternal age and week of gestation were included in the study. In addition to demographic characteristics, neonatal outcomes, and peripheral blood parameters, we examined whether there were differences between groups in NLR, PLR, MLR, SII, and SIRI scores. We also investigated the association between systemic inflammatory markers and neonatal intensive care unit (NICU) admission. P-values < 0.05 were interpreted as statistically significant. Results:The FGR group had higher leukocyte, neutrophil, NLR, and SII values than the control group (p=0.019; p=0.007; p=0.011; p=0.005, respectively). For the diagnosis of FGR, an optimal cut-off value of ≥4.7946 was found for NLR (with 54.7% sensitivity and 85.7% specificity) and a value of ≥918.15 for SII (with 67.1% sensitivity and 60% specificity). PLR and SII were higher in the FGR group with NICU admission than in the FGR group without NICU admission (p=0.024; p=0.012, respectively). Conclusion:SII, in addition to other clinical data, may contribute to both the diagnosis of FGR and the prediction of NICU admission in FGR cases. This finding is supported by randomized controlled trials with large series of prospective subgroup analyses.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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The significance of Systemic Immune Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) in fetuses with fetal growth restriction

Ağaoğlu

2023

Acad J Health

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Transamniotic Stem Cell Therapy Modulates Uterine Natural Killer Cell Activity in the Hypoxia Model of Intrauterine Growth Restriction

Whitlock,

Moskowitzova,

Kycia

et al. 2024

Stem Cells and Development

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Role of Inflammatory Markers and Doppler Parameters in Late‐Onset Fetal Growth Restriction: A Machine‐Learning Approach

Ulusoy,

Kurt,

Seyhanli

et al. 2024

American J Rep Immunol

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ObjectivesThis study evaluates the association of novel inflammatory markers and Doppler parameters in late‐onset FGR (fetal growth restriction), utilizing a machine‐learning approach to enhance predictive accuracy.Materials and MethodsA retrospective case–control study was conducted at the Department of Perinatology, Ministry of Health Etlik City Hospital, Ankara, from 2023 to 2024. The study included 240 patients between 32 and 37 weeks of gestation, divided equally between patients diagnosed with late‐onset FGR and a control group. We focused on novel inflammatory markers—systemic immune‐inflammation index (SII), systemic inflammatory response index (SIRI), and neutrophil‐percentage‐to‐albumin ratio (NPAR)—and their correlation with Doppler parameters of umbilical and uterine arteries. Machine‐learning algorithms were employed to analyze the data collected, including demographic, neonatal, and clinical parameters, to develop a predictive model for FGR.ResultsThe machine‐learning model, specifically the Random Forest algorithm, effectively integrated the inflammatory markers with Doppler parameters to predict FGR. NPAR showed a significant correlation with FGR presence, providing a robust tool in the predictive model (Accuracy 77%, area under the curve [AUC] 0.851). In contrast, SII and SIRI, while useful, did not achieve the same level of predictive accuracy (Accuracy 75% AUC 0.818 and Accuracy 73% AUC 0.793, respectively). The model highlighted the potential of combining ultrasound measurements with inflammatory markers to improve diagnostic accuracy for late‐onset FGR.ConclusionsThis study illustrates the efficacy of integrating machines with traditional diagnostic methods to enhance the prediction of late‐onset FGR. Further research with a larger cohort is recommended to validate these findings and refine the predictive model, which could lead to improved clinical outcomes for affected pregnancies.Trial RegistrationClinicalTrials.gov identifier: NCT06372938

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Neutrophil infiltration leads to fetal growth restriction by impairing the placental vasculature in DENV-infected pregnant mice

Cited by 5 publications

References 76 publications

The significance of Systemic Immune Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) in fetuses with fetal growth restriction

The significance of Systemic Immune Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) in fetuses with fetal growth restriction

Transamniotic Stem Cell Therapy Modulates Uterine Natural Killer Cell Activity in the Hypoxia Model of Intrauterine Growth Restriction

Role of Inflammatory Markers and Doppler Parameters in Late‐Onset Fetal Growth Restriction: A Machine‐Learning Approach

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