2024
DOI: 10.7150/thno.90370
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Neutrophil-like pH-responsive pro-efferocytic nanoparticles improve neurological recovery by promoting erythrophagocytosis after intracerebral hemorrhage

Linfeng Fan,
Lulu Jin,
Tianchi Tang
et al.

Abstract: Rationale: Intracerebral hemorrhage (ICH) is a devastating cerebrovascular disease resulting from blood extravasating into the brain parenchyma. Escalation of erythrophagocytosis (a form of efferocytosis), avoiding the consequent release of the detrimental erythrocyte lysates, may be a promising target of ICH management. The ADAM17 inhibitor and liver X receptor (LXR) agonist could promote efficient efferocytosis and injury repair. Nevertheless, the poor bioavailability and restriction of the blood-… Show more

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“…This suggests that combining natural cell membranes with nanomaterials is a novel and reliable method for drug delivery. 46…”
Section: Application Of Nanomaterials In the Treatment Of Ichmentioning
confidence: 99%
“…This suggests that combining natural cell membranes with nanomaterials is a novel and reliable method for drug delivery. 46…”
Section: Application Of Nanomaterials In the Treatment Of Ichmentioning
confidence: 99%