Neutrophil/lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorder

Abstract

Objectives: This study aims at researching the inflammatory cells and their ratios as inflammation markers in different phases of patients with bipolar disorder (BD). Methods: In this retrospective study, 79 manic, 61 depressed, 59 euthymic drug-naive patients with BD, and 86 control subjects have been evaluated for their complete blood count. Results: Neutrophil/lymphocyte ratio (NLR) was found to be significantly higher in manic, euthymic, and depressed patients with BD compared to control group. However, no difference was found between all patient and control groups regarding platelet/lymphocyte ratio (PLR). There was no difference among different phases of patient groups in terms of NLR and PLR. Conclusions: Our findings suggest that inflammatory process may have a role in all mood episodes of BD and NLR may be a useful trait inflammation marker for BD independent of mood episodes. However, further studies need to be conducted on the effect of inflammatory mechanisms on mood states of BD. ARTICLE HISTORY

Neutrophil-to-Lymphocyte Ratio, a Novel Inflammatory Marker, as a Predictor of Bipolar Type in Depressed Patients: A Quest for Biological Markers

“…NLR, PLR and MLR have been studied in psychiatric disorders, including MDD and BD [24]. Numerous studies have established NLR and PLR as biomarkers for the manic phase of bipolar disorder [29][30][31][32][33][34][35]. These results have been confirmed by a meta-analysis conducted by Mazza et al (2018).…”

Evaluation of the Indicators of Inflammation in Children and Adolescents with Attention Deficit and Hyperactivity Disorder: Effect of Sex and Subtype

“…In a study on platelet and MPV levels in ADHD, MPV found to be higher than controls, but no difference found in platelet levels (22). There are some studies which indicate NLR as an inflammatory marker can increase in depression, bipolar disorder and schizophrenia (19,(23)(24)(25)(26). PLR is a sensitive inflammatory marker and prognostic factor in some malignancies (27).…”

Comparison of the intensity of peripheral inflammation between major depressive disorder and bipolar depression by means of neutrophil-lymphocyte and plateletlymphocyte ratios: The possible role of clinical severity and psychotic features

“…NLR has been repetitively tested as a candidate parameter for systemic inflammation in neuropsychiatric disorders such as Alzheimer's disease [13] and schizophrenia [14,15]. A few studies also attempted to examine peripheral inflammatory response in mood disorders by means of NLR and/or PLR, with their findings collectively suggesting that MDD [16], as well as different mood episodes of BD [17] are associated with increased NLR and/or PLR compared to HC. On the other hand, some other studies addressing the relationship between clinical severity of MDD and NLR-PLR provided rather inconsistent findings [18,19].…”