Neutrophil:Lymphocyte Ratio and Intraoperative Use of Ketorolac or Diclofenac are Prognostic Factors in Different Cohorts of Patients Undergoing Breast, Lung, and Kidney Cancer Surgery

Forget, Patrice; Machiels, Jean‐Pascal; Coulie, Pierre G.; Berlière, Martine; Poncelet, Alain; Tombal, Bertrand; Stainier, A.; Legrand, Catherine; Canon, Jean-Luc; Kremer, Y.; Kock, Marc De

doi:10.1245/s10434-013-3136-x

Cited by 140 publications

(126 citation statements)

References 40 publications

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“…Several studies reported that high NLR value is always associated with inflammation, poor survival and a higher risk of distant metastasis [52,53]. The patients could be separated into two groups according to their NLR values.…”

Section: Discussionmentioning

confidence: 99%

Autofluorescence Imaging and Spectroscopy of Human Lung Cancer

et al. 2016

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Lung cancer is one of the most common cancers, with high mortality rate worldwide. Autofluorescence imaging and spectroscopy is a non-invasive, label-free, real-time technique for cancer detection. In this study, lung tissue sections excised from patients were detected by laser scan confocal microscopy and spectroscopy. The autofluorescence images demonstrated the cellular morphology and tissue structure, as well as the pathology of stained images. Based on the spectra study, it was found that the majority of the patients showed discriminating fluorescence in tumor tissues from normal tissues. Therefore, autofluorescence imaging and spectroscopy may be a potential method for aiding the diagnosis of lung cancer.

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Section: Discussionmentioning

confidence: 99%

Autofluorescence Imaging and Spectroscopy of Human Lung Cancer

et al. 2016

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“…The peripheral blood absolute neutrophil count/absolute lymphocyte count ratio (ANC/ALC) or the neutrophil/lymphocyte ratio (NLR) at diagnosis is also a prognostic indicator in malignant tumors including breast cancer [45][46][47][48]. Furthermore, recent studies have revealed that NLR is a negative predictive factor of advanced esophageal cancer [49], stage III-IV gastric cancer [50], and breast cancer with ER/PR-positivity and HER2-negativity in the NAC setting [51].…”

Section: Discussionmentioning

confidence: 99%

Prognostic and predictive value of NanoString-based immune-related gene signatures in a neoadjuvant setting of triple-negative breast cancer: relationship to tumor-infiltrating lymphocytes

Lee

Song

et al. 2015

Breast Cancer Res Treat

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The prognostic significance of tumor-infiltrating lymphocytes and immune signals has been described previously in triple-negative breast cancer (TNBC). Furthermore, recent studies have shown that immunologic parameters are relevant for the response to neoadjuvant chemotherapy (NAC) in breast cancer as well as for outcomes after adjuvant chemotherapy. However, immune signals are variable, and which signals are important is largely unknown. We, therefore, evaluated the expression of immune-related genes in TNBC treated with NAC. We retrospectively evaluated biopsy tissue from 55 patients with primary TNBC treated with NAC (anthracycline, cyclophosphamide, and docetaxel) against the NanoString nCounter GX Human Immunology Panel (579 immune-related genes). Higher expression of cytotoxic molecules, T cell receptor signaling pathway components, cytokines related to T helper cell type 1 (Th1), and B cell markers was associated with a pathologic complete response (pCR). Higher expression of NFKB1, MAPK1, TRAF1, CXCL13, GZMK, and IL7R was significantly associated with pCR, higher Miller-Payne grade, and lower residual cancer burden class. Expression of NFKB1, TRAF1, and CXCL13genes, in particular, was significantly correlated with a longer disease-free survival rate. Conversely, patients those who failed to achieve a pCR showed increased expression of genes related to neutrophils. Higher expression of cytotoxic molecules, T cell receptor signaling pathway components, Th1-related cytokines, and B cell markers is correlated with pCR and survival in TNBC patients treated with NAC. Our results suggest that the activation status of neutrophils may provide additional predictive information for TNBC patients treated with NAC.

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“…For clinical application, we have to confirm the predictive role of the immediate postoperative NLR and examine whether the control of perioperative inflammation decreases the NLR and finally leads to good clinical outcomes. Forget et al [11,14] showed that the intraoperative administration of nonsteroidal anti-inflammatory drugs (NSAIDs) and lower NLR levels were associated with longer disease-free and overall survival in breast cancer. However, they did not show a direct correlation between the administration of NSAIDs and the lowering of the NLR.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have investigated the prognostic value of the NLR at each stage and by several treatments in a variety of tumors, mostly in the gastrointestinal tract [5,6,7,8,9,10]. Although studies examining the NLR and breast cancer have been relatively small, they have consistently shown that preoperative inflammation measured with the NLR was associated with poor outcomes in breast cancer [11,12,13,14,15,16]. …”

Section: Introductionmentioning

confidence: 99%

Immediate Postoperative Inflammation Is an Important Prognostic Factor in Breast Cancer

et al. 2015

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Objective: Inflammation is associated with worse outcomes in cancer. Operations induce an acute inflammatory response and could impact the clinical outcomes in breast cancer. The neutrophil-lymphocyte ratio (NLR) is a well-known indicator of inflammation. We investigated the prognostic significance of perioperative inflammation with the NLR in breast cancer. Methods: We reviewed the clinical and pathological records of women diagnosed with invasive breast carcinoma at the Samsung Medical Center between 2000 and 2010. The NLR levels in the immediate preoperative period and the postoperative periods (1 week and 1 month) were assessed. Results: The NLRs of a total of 3,116 breast cancer patients were examined. In the univariate analysis, the NLR in postoperative week 1, total mastectomy, the presence of lymphovascular invasion, a higher nuclear grade and pathologic TNM stage, and negative hormone receptor and subtypes were factors associated with poor disease-specific survival. The NLR in postoperative week 1 remained a significant prognostic factor in the multivariate analysis. A cutoff level of 5.2, determined by the minimum p value approach, was found to be a significant level for discriminating the impact on breast cancer-specific mortality (p = 0.0116 adjusted by the Bonferroni correction). Conclusions: Immediate postoperative inflammation is an important prognostic marker in breast cancer patients.

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Neutrophil:Lymphocyte Ratio and Intraoperative Use of Ketorolac or Diclofenac are Prognostic Factors in Different Cohorts of Patients Undergoing Breast, Lung, and Kidney Cancer Surgery

Abstract: In these cohorts, these analyses show that NLR is a strong perioperative prognosis factor for breast, lung, and kidney cancers. In this context, intraoperative NSAIDs administration could be associated with a better outcome.

Cited by 140 publications

References 40 publications

Autofluorescence Imaging and Spectroscopy of Human Lung Cancer

Autofluorescence Imaging and Spectroscopy of Human Lung Cancer

Prognostic and predictive value of NanoString-based immune-related gene signatures in a neoadjuvant setting of triple-negative breast cancer: relationship to tumor-infiltrating lymphocytes

Immediate Postoperative Inflammation Is an Important Prognostic Factor in Breast Cancer

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