Neutrophil/lymphocyte ratio and mean platelet volume in central serous chorioretinopathy

Abstract

PurposeThis study aimed to evaluate mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) values and their relationship with clinical findings in patients with central serous chorioretinopathy (CSCR).MethodsOverall, 87 patients fulfilling inclusion criteria and 320 age- and sex-matched healthy individuals as controls were included in the study. The CSCR patients (n=87) were classified into 2 groups as acute CSCR (group 1, n=43) and chronic CSCR (group 2, n=44).ResultsIt was found that NLR (P<0.05) and C-reactive protein (CRP) (P<0.05) values were higher in acute CSCR group than the other groups. MPV value was found to be higher in chronic CSCR group than the other groups (P<0.001).ConclusionIt seems that neutrophils play a major role in acute CSCR while platelets are involved in progression to chronic CSCR. Larger, prospective studies are needed on this topic.

Monocyte to high-density lipoprotein and neutrophil-to-lymphocyte ratios in patients with acute central serous chorioretinopathy

“…investigated NLRs and CRP levels in patients with acute or chronic CSC and found that both factors were significantly higher in patients with acute CSC than all others. [ 12 ] However, in multivariate analysis, NLRs and CRP values did not emerge as independent predictors of acute CSC. Their results are comparable with our findings.…”

“…Since the pathogenesis of CSC is associated with systemic inflammation, some researchers have used a range of candidate biomarkers from peripheral blood to investigate the systemic inflammatory and oxidative status in patients with CSC. [ 12 14 26 27 ] In two studies, in particular, the thiol-to-disulfide ratio from peripheral blood samples was investigated as a biomarker of oxidative stress in patients with either acute or chronic CSC. [ 14 26 ] The results of both studies indicated that the thiol-to-disulfide ratio was significantly lower in patients with chronic or acute CSC when compared with healthy subjects.…”

“…Some biochemical and radiological aspects, including C-reactive protein (CRP) levels, endothelium-dependent flow-mediated vasodilation, disulfide-to-thiol ratios, and neutrophil-to-lymphocyte ratios (NLR), have recently been studied as predictors of inflammation in patients with CSC. [ 12 13 14 ] At the same time, monocytes are important cells for inflammatory reactions and high-density lipoprotein (HDL) is known for its anti-inflammatory and antioxidant effects. [ 15 16 ] Thus, elevated monocyte counts and reduced high-density lipoprotein levels have been assessed as possible biomarkers of the systemic inflammatory process of the disorder.…”

Commentary: Systemic immune-inflammatory indices and their association with ocular disorders—Do we have economical and reliable biomarkers?

“…In CSCR, Erol and colleagues have demonstrated that NLR and C-reactive protein (CRP) are higher in patients with acute CSCR when compared to normal volunteers and patients with chronic CSCR. [ 11 ] They also noted that, in chronic CSCR, mean platelet volume was higher. The present paper by Sirakaya et al .…”

Comments on

“…They did not observe any difference in CRP or ESR values, attributing it to small sample size; nor did another cited study. [ 2 ]…”