Neutrophil–lymphocyte ratio as a new predictive and prognostic factor at the hearing loss of diabetic patients

Abstract

Diabetes mellitus (DM) is a systemic inflammatory disease. Sensorineural hearing loss (SNHL) is seen more frequently in diabetic patients and it is believed that vascular complications of DM may be the cause of SNHL via inflammation. Neutrophil-to-lymphocyte ratio (NLR) was defined as a novel-potential marker to determine inflammation. We aimed to investigate the relationship between NLR levels and SNHL in diabetic patients using high-frequency audiometry (8–16 kHz) for the first time. The study included 58 patients diagnosed with DM. The control group was composed of 45 age–sex–BMI–matched healthy subjects. An automated blood cell counter was used for NLR measurements. The hearing assessments of the patients were carried out by Interacoustics Clinical Audiometer AC 40 device. The mean NLR values of the patients were significantly higher than the control group (p = 0.015). Speech recognition threshold values were higher and the speech discrimination values were lower in patients (p = 0.002, p < 0.001), respectively. Pure tone average of the patients at 500, 1,000, 2,000 Hz frequencies was divided into two groups (group 1 >25 dB and group 2 <25 dB). NLR levels of the diabetic patients with >25 dB were higher than the other diabetics (p = 0.007). In conclusion, while diabetic patients are evaluating, audiologic assessments of these patients should be performed because they are at more risk of SNHL and NLR may be considered as a predictive and prognostic marker of hearing loss or its beginning in these patients as a useful and reliable marker without any cost.

Study of neutrophil-lymphocyte ratio as novel marker for diabetic nephropathy in type 2 diabetes

“…[26] Multiple studies have established that inflammatory markers such as neutrophilia and relative lymphocytopenia are independent markers of many diseases, especially complications of DM, such as DN. [101112202127] However, establishing a diagnosis individually based on WBC, neutrophil, or lymphocyte counts has its own biases, unlike NLR, which is a dynamic parameter that has a higher prognostic value. [111228]…”

“…Another recent study by Ulu et al . [27] concluded that NLR can be considered as a predictive and prognostic marker for sensorineural hearing loss in diabetic patients. A study conducted in geriatric population also suggested that increased NLR levels were in itself an independent predictor for microvascular complications of DM.…”

Could the Platelet-to-Lymphocyte Ratio be a Novel Marker for Predicting Invasiveness of Cervical Pathologies?

“…NLR was defined as a potential marker to determine inflammation in systemic disease (Walsh et al, 2005;Rudiger et al, 2006;Bucak et al, 2013;Ulu et al, 2013;Acmaz et al, 2014). Chronic inflammation in DM, like other chronic diseases, is well known (Schmidt MI, 1999).…”

Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes?

“…NLR was calculated as a ratio between the absolute neutrophil and lymphocyte counts (Ulu et al, 2014). Initially, patients with abnormal finding in glucose levels, creatinine, total cholesterol and triglycerides were excluded.…”