Neutrophil Lymphocyte Ratio as an Inflammatory Marker in Chronic Kidney Disease: Determinants and Correlates

Uduagbamen, Peter Kehinde; Oyelese, Adesola T.; AdebolaYusuf, Abdallah Olukayode; Thompson, Mary Umoh; Alalade, Boladale Ajani Afeez; Ehioghae, O.

doi:10.4236/ojneph.2022.121003

Cited by 5 publications

(12 citation statements)

References 28 publications

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“…In addition, elevated NLR was defined in our study using a cut-off of greater than 1.86 compared to the study by Ogiator et al (22) that used a lower cut-off of greater than 1.5. The prevalence of elevated NLR in our study is higher than 19.7% reported by Uduagbamen et al (15) in a study that was conducted among pre-dialysis CKD where a cut-off of ≥ 3 was used to define elevated NLR. However, the study by Uduagbamen et al (15) involved early stages of CKD (stages 1-4) unlike our study which involved stages 3-5.…”

Section: Discussioncontrasting

confidence: 76%

“…The prevalence of elevated NLR in our study is higher than 19.7% reported by Uduagbamen et al (15) in a study that was conducted among pre-dialysis CKD where a cut-off of ≥ 3 was used to define elevated NLR. However, the study by Uduagbamen et al (15) involved early stages of CKD (stages 1-4) unlike our study which involved stages 3-5. This may partly explain the higher prevalence of elevated NLR in our study compared to that of Uduagbamen et al (15).…”

Section: Discussioncontrasting

confidence: 76%

“…However, the study by Uduagbamen et al (15) involved early stages of CKD (stages 1-4) unlike our study which involved stages 3-5. This may partly explain the higher prevalence of elevated NLR in our study compared to that of Uduagbamen et al (15). In the same vein, the median value of PLR was significantly higher in the CKD group compared with the control group with normal renal function.…”

Section: Discussioncontrasting

confidence: 62%

“…N=minimum sample size; Z1-a/2= level of significance at 95% confidence interval = 1.96; P= available prevalence of elevated NLR (19. 7%) from a previous study done among CKD patients (15); d = degree of precision limit required =5 % (0.05) so n = 243. For small finite population, the corrected sample size is; Nf = n/1+n-1/N.…”

Section: Sample Size Determinationmentioning

confidence: 99%

“…The PLR was calculated by dividing absolute platelet count by absolute lymphocyte count. An NLR and PLR values of >1.86 and >160 respectively, were considered elevated (10,15).…”

Section: Data Collectionmentioning

confidence: 99%

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Surrogate Inflammatory Markers and Some Correlates in Pre-dialysis Chronic Kidney Disease Patients: a cross-sectional study

Mamven

Ucha

Adejumo

2022

Babcock Univ. Med. J.

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Objective: Chronic kidney disease is characterized by a state of chronic inflammation which is associated with poor cardiovascular disease outcomes. The study determined the prevalence of elevated neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as surrogate markers of inflammation and their association with some cardiovascular risk factors among pre-dialysis CKD patients. Method: This was a cross-sectional study to determine and compare the prevalence of elevated NLR and PLR. The correlation between these surrogate inflammatory markers and some cardiovascular risk factors was determined. Data were analyzed using SPSS version 21 software. P-value of < 0.05 was taken as significant. Results: This study involved 51 pre-dialysis CKD patients and 51 controls with mean ages of 50.96±11.42 years and 48.31±9.83 years, respectively. The prevalence of elevated NLR was significantly higher in the CKD group (35.3% vs13.7%; P=0.010). In the CKD group, there was significant negative correlation between NLR and eGFR (r= -0.393; P=0.004), hemoglobin concentration (r= -0.543; P=<0.001) and HDL (r= -0.292; P=0.037). There was significant positive correlation between NLR and PLR (r=0.669; P=<0.001), TC:HDL (r=0.334; P=0.017), AIP(r=0.289; P=0.042) and LDL:HDL (r=0.320; P=0.020). There was significant positive correlation between PLR, NLR (r=0.695; P=<0.001) and AIP (r=0.283; P=0.047). There was significant negative correlation between PLR and estimated GFR (r=- 0.448; P=0.001), hemoglobin concentration (r= -0.596; P=<0.001), serum albumin (r= -0.388; P=0.005), serum HDL-C (r= -0.387; P= 0.005). Conclusion: NLR and PLR were significantly higher in pre-dialysis CKD patients and were associated with cardiovascular risk. They should be routinely used to identify those with high cardiovascular risk.

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Section: Discussioncontrasting

confidence: 76%

Section: Discussioncontrasting

confidence: 76%

Section: Discussioncontrasting

confidence: 62%

Section: Sample Size Determinationmentioning

confidence: 99%

“…The PLR was calculated by dividing absolute platelet count by absolute lymphocyte count. An NLR and PLR values of >1.86 and >160 respectively, were considered elevated (10,15).…”

Section: Data Collectionmentioning

confidence: 99%

See 3 more Smart Citations

Surrogate Inflammatory Markers and Some Correlates in Pre-dialysis Chronic Kidney Disease Patients: a cross-sectional study

Mamven

Ucha

Adejumo

2022

Babcock Univ. Med. J.

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COVID-19 increases mortality in hemodialysis patients: exploring links with inflammation and telomere attrition

Milosevic,

Naumovic,

Sopic

et al. 2024

Mol Biol Rep

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Pattern of Eosinophil and Neutrophil/ Lymphocyte Ratio in Different Stages of Chronic Kidney Disease.

Ali,

Devi

et al. 2024

Bangladesh Med J

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Various expensive interventions are used to diagnosis the different stages of chronic kidney disease (CKD). This research is aimed to determine the pattern of eosinophil and neutrophil/ lymphocyte ratio in different stages of CKD. Data was collected in January 2023 from the patients of CKD and from their files of reports. Permission was taken from the patients. The individuals were from civil hospital Karachi and they were the patients of CKD. Sample size was 200. There was irregular pattern of eosinophil and neutrophil/lymphocyte ratio in different stages of CKD. The eosinophil count and neutrophil/ lymphocyte ratio were higher in higher stages of CKD. The eosinophil and neutrophil/ lymphocyte ratio were higher in higher stages of CKD and the pattern was irregular. Study finds that eosinophil and neutrophil/ lymphocyte ratio were higher and the pattern was irregular in higher stages of CKD. Bangladesh Med J. 2023 Jan; 52(1): 24-29

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Neutrophil Lymphocyte Ratio as an Inflammatory Marker in Chronic Kidney Disease: Determinants and Correlates

Cited by 5 publications

References 28 publications

Surrogate Inflammatory Markers and Some Correlates in Pre-dialysis Chronic Kidney Disease Patients: a cross-sectional study

Surrogate Inflammatory Markers and Some Correlates in Pre-dialysis Chronic Kidney Disease Patients: a cross-sectional study

COVID-19 increases mortality in hemodialysis patients: exploring links with inflammation and telomere attrition

Pattern of Eosinophil and Neutrophil/ Lymphocyte Ratio in Different Stages of Chronic Kidney Disease.

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