Neutrophil: lymphocyte ratio is positively associated with subclinical diabetic cardiomyopathy

Huang, Xiaoli; Qin, Zihan; Xu, Min; Zhang, Feifei; Jiang, Xiaohong; Fang, Hua; Tao, Lichan

doi:10.1186/s12902-020-00571-y

Cited by 12 publications

(10 citation statements)

References 37 publications

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“…Neutrophils are first-responders and secrete various inflammatory mediators, such as cytokines, microparticles, and neutrophil extracellular traps (NETs), which induce sustained inflammation. Of note, an increased neutrophil/lymphocyte ratio was recently identified as an indicator associated with subclinical DCM ocurrence ( Huang et al, 2020 ). Furthermore, elevated NET release following protein arginine deiminase upregulation in neutrophils ( Wong et al, 2015 ) aggravates cardiac injury due to neutrophil-mediated cell death (NETosis) in diabetes ( Fadini et al, 2016 ).…”

Section: Myocardial Inflammation In Diabetic Cardiomyopathymentioning

confidence: 99%

Mechanisms and Therapeutic Prospects of Diabetic Cardiomyopathy Through the Inflammatory Response

et al. 2021

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The incidence of heart failure (HF) continues to increase rapidly in patients with diabetes. It is marked by myocardial remodeling, including fibrosis, hypertrophy, and cell death, leading to diastolic dysfunction with or without systolic dysfunction. Diabetic cardiomyopathy (DCM) is a distinct myocardial disease in the absence of coronary artery disease. DCM is partially induced by chronic systemic inflammation, underpinned by a hostile environment due to hyperglycemia, hyperlipidemia, hyperinsulinemia, and insulin resistance. The detrimental role of leukocytes, cytokines, and chemokines is evident in the diabetic heart, yet the precise role of inflammation as a cause or consequence of DCM remains incompletely understood. Here, we provide a concise review of the inflammatory signaling mechanisms contributing to the clinical complications of diabetes-associated HF. Overall, the impact of inflammation on the onset and development of DCM suggests the potential benefits of targeting inflammatory cascades to prevent DCM. This review is tailored to outline the known effects of the current anti-diabetic drugs, anti-inflammatory therapies, and natural compounds on inflammation, which mitigate HF progression in diabetic populations.

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Section: Myocardial Inflammation In Diabetic Cardiomyopathymentioning

confidence: 99%

Mechanisms and Therapeutic Prospects of Diabetic Cardiomyopathy Through the Inflammatory Response

et al. 2021

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“… 11–14 In addition, other researchers have found that NLR levels association with diagnosis and prognosis of infectious diseases such as community-acquired pneumonia, 15 bacteremia, and sepsis. 16–20 Elevated NLR also has been found in patients with chronic diseases including prediabetes and diabetes mellitus, 21 , 22 autoimmune diseases, 23 , 24 and metabolic syndrome. 25 These evidence suggest NLR as a risk factor of various diseases, but the insufficient number of participants and the short follow-up period undermine the validity of the results.…”

Section: Introductionmentioning

confidence: 99%

Association Between Neutrophil-Lymphocyte Ratio and All-Cause Mortality and Cause-Specific Mortality in US Adults, 1999–2014

Chen¹,

Wang²,

Zeng³

et al. 2021

IJGM

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Background Neutrophil-lymphocyte ratio (NLR) is a novel marker of inflammation. Emerging studies have evaluated the relationship of NLR with cardiovascular diseases and malignant conditions. However, rare studies regarded the association between NLR and long-term health status. This study aimed to evaluate the association of NLR with all-cause mortality and cause-specific mortality among adults in the United States. Methods We obtained eight cycles data of National Health and Nutrition Examination Surveys (NHANES) from 1999 to 2014, and enrolled 32328 participants after certain screening. By weighted chi-square test and linear regression analysis, we analyzed the correlation between NLR and baseline characteristics of the participants. Kaplan–Meier curves and Cox regression models were used to assess the survival relevance of NLR. We conducted stratified analysis, interaction analysis, and sensitivity analysis to robustness of our results. Results Participants with high NLR levels had a higher risk of death. After adjustment for baseline characteristics, the hazard ratio comparing the higher vs lower NLR levels was 1.43 (95% CI, 1.18–1.73) for all-cause mortality, 1.27 (95% CI, 0.84–1.92) for cancer mortality, and 1.44 (95% CI, 0.96–2.16) for cardiovascular disease mortality. Stratified analysis found that the observed associations between NLR levels and mortality did not differ significantly. Conclusion In this nationally representative cohort of US adults, higher NLR was significantly associated with an increased risk of all-cause mortality.

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“…As the first line of defense in the inflammatory response, neutrophils play an important role in the immune response. Studies have shown that neutrophil-to-lymphocyte ratios (NLR) are associated with diabetic heart damage ( 47 , 48 ). A recent study suggested that inflammatory serine proteases produced by neutrophils can aggravate diabetic cardiomyopathy and promote the development of HF ( 49 ).…”

Section: Discussionmentioning

confidence: 99%

Identification and verification of immune-related biomarkers and immune infiltration in diabetic heart failure

Zhong

Zhang²,

Xu³

et al. 2022

Front. Cardiovasc. Med.

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PurposeDiabetic heart failure (DHF) or cardiomyopathy is a common complication of diabetes; however, the underlying mechanism is not clear. In the present study, the authors searched for differentially expressed genes associated with DHF and the molecular types of immune cells based on bioinformatics.MethodsThe RNA expression dataset of DHF was obtained from the NCBI Gene Expression Omnibus (GEO) database. After preprocessing the data, the differentially expressed genes (DEGs) between the DHF group and the non-diabetic heart failure (NHF) group were screened and intersected with immune-related genes (IRGs) in the ImmPort database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed using the DAVID tool. The ssGSEA algorithm was used to evaluate immune infiltration of the heart tissue in each group. In addition, the protein-protein interaction (PPI) network and miRNA-mRNA network were constructed using the STRING online website and Cytoscape program. Finally, validation analysis was performed using animal models.ResultsEight immune-related core genes were identified. GO and KEGG showed that core genes were mainly enriched in angiogenesis and cytokine-cytokine receptor interaction. Immune infiltration results showed that activated dendritic cells, central memory CD4 T cells, central memory CD8 T cells, myeloid-derived suppressor cells (MDSCs), neutrophils, and regulatory T cells may be involved in DHF. Neutrophils may play a key role in the pathogenesis of HF in diabetes.ConclusionImmune-related core genes and immune infiltrating cells provide a new perspective on the pathogenesis of DHF.

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Neutrophil: lymphocyte ratio is positively associated with subclinical diabetic cardiomyopathy

Cited by 12 publications

References 37 publications

Mechanisms and Therapeutic Prospects of Diabetic Cardiomyopathy Through the Inflammatory Response

Mechanisms and Therapeutic Prospects of Diabetic Cardiomyopathy Through the Inflammatory Response

Association Between Neutrophil-Lymphocyte Ratio and All-Cause Mortality and Cause-Specific Mortality in US Adults, 1999–2014

Identification and verification of immune-related biomarkers and immune infiltration in diabetic heart failure

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