Neutrophil-lymphocyte ratio may be superior to C-reactive protein for predicting the occurrence of postmenopausal osteoporosis

Yilmaz, Hınç; Uyfun, M; Yilmaz, Tayfun; Namuslu, Mehmet; İnan, Osman; Taşkın, Abdullah; Çakmak, Murat; Bilgiç, Mukadder Ayşe; Bavbek, Nükhet; Akçay, Ali; Koşar, Alim

doi:10.4149/endo_2014_01_25

Cited by 38 publications

(51 citation statements)

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“…In this context, it has been suggested a synergistic effect of hyperglycemia and coeliac autoimmunity on low BMD [58]. Although Post-M presented more comorbidities (Table 2) and osteoporosis (Table 3) and, overall, subjects with osteoporosis had higher recent NLR compared to patients with osteopenia or normal BMD (Table 4), as previously reported [54], Pre-MPP had higher recent NLR (Table 5).…”

Section: Discussionsupporting

confidence: 77%

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Neutrophil-to-Lymphocyte Ratio, Mediterranean Diet, and Bone Health in Coeliac Disease Patients: A Pilot Study

Palmacci¹,

Toti

Raguzzini

et al. 2019

Oxidative Medicine and Cellular Longevity

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Neutrophil-to-lymphocyte ratio (NLR) has been proposed as a bone loss index in postmenopausal women and as a marker of inflammation in coeliac patients. The aims of this work were to evaluate the effect of gluten-free diet (GFD) on NLR retrospectively and study the relationship between NLR and Mediterranean diet adherence and selected food groups (fruits, vegetables, red meat, potatoes, and unrefined and refined cereals). Adult individuals (n=50), who had been on a strict GFD by at least 6 months, were recruited. The degree of adherence to the Mediterranean diet was calculated with two different scores: the Mediterranean Diet Score (MDS-14), assessed through the validated 14-item questionnaire of the PREDIMED study, and the MEDScore (Score-55) proposed by Panagiotakos. The latter includes the consumption of unrefined cereals (UC). High percentages of osteopenia and osteoporosis were found within the recruited subjects, who furnished the reports of bone mineral density (BMD), in particular in postmenopausal (Post-M) women. Recent NLR was higher in subjects with osteoporosis compared to osteopenia and normal BMD. However, retrospective analysis showed both increase and decrease in NLR after GFD, with no significant differences between Marsh grade, anemia, and BMD status. Moreover, premenopausal previous pregnancy (Pre-MPP) and Post-M had higher NLR at diagnosis compared to Men and premenopausal (Pre-M), but higher differences were observed in recent NLR between Pre-MPP and Men only. Chocolate consumption was associated with lower recent NLR, whereas the latter was correlated with Score-55, but not with MDS-14. Moreover, refined cereal consumption was correlated with recent NLR. Although large prospective studies are needed in order to clarify the relationship between UC and NLR in coeliac patients, in this pilot study, we have investigated for the first time the relationship between NLR, dietary habit, and osteoporosis in coeliac disease.

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Section: Discussionsupporting

confidence: 77%

“…From 50 subjects, after the selection for anti-Tg at diagnosis, we retrospectively evaluated 46 adult-diagnosed (Table 2) coeliac disease patients at GFD. In this study, we evaluated NLR, being a marker of inflammation in coeliac disease [8, 9] related to postmenopausal osteoporosis [8, 54].…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio, Mediterranean Diet, and Bone Health in Coeliac Disease Patients: A Pilot Study

Palmacci¹,

Toti

Raguzzini

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…Fisher et al,21 stated that high N/L displayed as a potential indicator of bone fracture. Although Yılmaz et al,22 showed that N/L and CRP were significantly higher in the osteoporotic group than in the control group, N/L was found to be more effective for predicting PMO than CRP. There is only one study exploring the association of P/L and PMO along with N/L 23.…”

Section: Discussionmentioning

confidence: 86%

Platelet/lymphocyte ratio is an independent predictor for osteoporosis

Eroğlu

Karataş²

2019

SMJ

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Objectives: To investigate the intercourse between the platelet/lymphocyte (P/L) and neutrophil/lymphocyte ratio (N/L), and vitamin D (Vit-D) levels in low bone mineral density (BMD) of women. Methods: Two hundred fifty-two postmenopausal female outpatients who were admitted to the obstetrics and gynecology and physical therapy clinics between July 2016 and December 2017 were retrospectively analyzed. The patients were grouped in relation to their T-score (normal [n=92], osteopenia [n=112], and PMO [n=48]). The serum levels of P/L, N/L, Vit-D, BMD and complete blood count of the patients were retrospectively examined. Results: The median P/L was significantly higher and Vit-D levels were significantly lower in the PMO group (130.75 [52.89-385] versus 123.05 [54-232.5], p =0.02 and 15.4 [4-34] versus 20.1 [4-47], p =0.003). While BMD and P/L were negatively correlated, a positive correlation between BMD and Vit-D was found. Vitamin D levels were negatively correlated with P/L ( p <0.001) and N/L ( p =0.04). Older age (≥65 years), Vit-D deficiency and P/L values >125.06 were found as independent prognostic factors for PMO in regression analysis. Conclusion: Higher P/L seems to be a quite simple marker to help predict postmenopausal PMO. As seen in our study, having low levels of Vit-D is crucial for PMO.

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“…A recent study conducted by Yilmaz et al indicated that NLR was better than CRP for predicting the occurrence of osteoporosis [35]. Several potential mechanisms may explain the association between NLR and cardiovascular disease: neutrophils are proinflammatory cells, which could aggravate endothelial dysfunction, activate macrophages, and promote foam cell formation [36]; meanwhile, lymphopenia is associated with the progression of atherosclerosis and adverse cardiovascular outcomes, which may be due to the apoptosis of lymphocytes [37].…”

Section: Discussionmentioning

confidence: 99%

High Neutrophil-to-Lymphocyte Ratio is a Significant Predictor of Cardiovascular and All-Cause Mortality in Patients Undergoing Peritoneal Dialysis

Wang

Zhang

et al. 2018

Kidney Blood Press Res

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Background/Aims: Chronic inflammation is associated with increased risk of cardiovascular death in patients with end-stage renal disease (ESRD). Although elevated neutrophil-tolymphocyte ratio (NLR), a novel inflammatory marker, has been shown to predict cardiovascular disease and all-cause mortality in the general population, limited evidence is available for its role in ESRD. Methods: We enrolled 86 patients undergoing peritoneal dialysis (PD) for a 36-month follow-up to investigate the association between the NLR and arterial stiffness markers, namely, carotid-femoral pulse wave velocity (cfPWV) and carotid augmentation index (AIx), and mortality in PD patients. The primary endpoints were cardiovascular mortality and all-cause mortality. Kaplan-Meier curves were used to show the cumulative incidence of cardiovascular mortality and all-cause mortality. Results: High NLR was found to be a predictor of increased cfPWV (β = 1.150; P < 0.001) and AIx (β = 3.945; P < 0.001) in patients on PD. Patients with higher NLR had lower survival during follow-up. Kaplan-Meier curves showed that the cumulative incidences of both cardiovascular mortality and all-cause mortality were significantly higher in patients with NLR ≥ 4.5 (both P < 0.01). Conclusion: Our results suggest that high NLR is independently associated with arterial stiffness and predicts cardiovascular and all-cause mortality in PD patients.

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Neutrophil-lymphocyte ratio may be superior to C-reactive protein for predicting the occurrence of postmenopausal osteoporosis

Abstract: Our data indicate that NLR may be a better predictor than CRP for occurrence of osteoporosis in postmenopausal women.

Cited by 38 publications

References 0 publications

Neutrophil-to-Lymphocyte Ratio, Mediterranean Diet, and Bone Health in Coeliac Disease Patients: A Pilot Study

Neutrophil-to-Lymphocyte Ratio, Mediterranean Diet, and Bone Health in Coeliac Disease Patients: A Pilot Study

Platelet/lymphocyte ratio is an independent predictor for osteoporosis

High Neutrophil-to-Lymphocyte Ratio is a Significant Predictor of Cardiovascular and All-Cause Mortality in Patients Undergoing Peritoneal Dialysis

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