Neutrophil-mediated Thrombosis and NETosis in Behçet's Disease: a Hypothesis

Batu, Ezgi Deniz

doi:10.3346/jkms.2020.35.e213

Cited by 13 publications

(11 citation statements)

References 33 publications

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“…As a result of systemic inflammation, oral-genital ulcers, ocular, cerebral, and gastrointestinal disorders can accompany the clinical presentation. 1 2 3 BD has a geographic distribution and is more common in countries along the route known as the ancient Silk Road. The spread of various genetic factors, including HLA-B51, along this route, may trigger the emergence of such a distribution.…”

Section: Introductionmentioning

confidence: 99%

Bibliometric and Altmetric Analyses of Publication Activity in the Field of Behcet's Disease in 2010–2019

Koçyiğit

Akyol

2021

J Korean Med Sci

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Background Behcet's disease (BD) is a systemic vasculitis accompanied by oral-genital ulcers, ocular, cerebral, and gastrointestinal disorders. The aim of this study was to evaluate BD articles published between 2010–2019 bibliometrically and to provide up-to-date data. A secondary aim was to present a different perspective using altmetric assessments. Methods This bibliometric and altmetric research was performed with data obtained from the Web of Science database. The key terms “Behcet's disease,” “Behcet's syndrome,” and “Behcet” were used for listing the articles. The number of articles, citation data, and active countries were determined. Trend and correlation analyses were performed. Altmetric attention scores (AASs) and Mendeley readers count (MRC) of the articles were acquired for the altmetric evaluations. Results A total of 5,201 articles were listed. After the exclusion criteria, a total of 2,163 articles were obtained for further analysis. A significant and increasing trend was detected in the number of articles from 2010 to 2019 ( P < 0.001). Turkey (28.24%), China (9.57%), South Korea (9.20%), Japan (6.38%), and Italy (5.64%) were the five most productive countries. France, the United States and, the United Kingdom were the top three countries in respect of the average number of citations per article. A weak significant correlation was detected between the number of citations and AAS ( P < 0.001). The number of citations was significantly and strongly correlated with the MRC ( P < 0.001). Conclusion An increasing trend was found in BD research productivity. Although the Silk Road countries were prominent in the number of articles, a similar ranking was not valid for the average number of citations per article.

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Section: Introductionmentioning

confidence: 99%

Bibliometric and Altmetric Analyses of Publication Activity in the Field of Behcet's Disease in 2010–2019

Koçyiğit

Akyol

2021

J Korean Med Sci

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“…Impaired endothelium is a significant cause of vascular obstruction. Meanwhile, damaged endothelial cells also release procoagulant factors and facilitate neutrophils and platelet aggregation, leading to a thrombotic tendency (31). Moreover, increased ROS leads to fibrinogen posttranslational modifications and reduces fibrin susceptibility to plasmin lysis, which augments coagulation (30).…”

Section: Discussionmentioning

confidence: 99%

The clinical features, image findings and risk factors of vena cava syndrome in Behçet's syndrome

Zhou

Wang

Hou

et al. 2022

Clinical and Experimental Rheumatology

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Objective To investigate the clinical features, image findings, and potential risk factors of vena cava syndrome (VCS) inBehçet's syndrome (BS). MethodsWe conducted a case-control study in our BS registry database from 2012 to 2021. Fifty-five BS patients with VCS were enrolled in the case group, and two BS patients without VCS were selected as controls for each VCS case using risk-set-sampling. Multivariable logistic regression was used to detect the risk factors of VCS, and the outcome of these patients was also analysed. We also conducted an exploratory study to evaluate spectral computed tomography (CT) imaging in detecting thrombosis in BS patients with inferior VCS (IVCS).

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“…Indeed, it has been recently shown that neutrophil activation promotes fibrinogen oxidation and thrombosis formation in BS. Specifically, these findings suggest that altered fibrinogen structure and fibrinogen function are related to neutrophil activation and production of enhanced ROS, which are mainly derived from neutrophil NADPH oxidases (55). In addition to the role of ROS, other mechanisms implicated in typical thrombo-inflammation are also documented, including the release of neutrophil extracellular traps (NETs) (56).…”

Section: Immunological Etiology Neutrophil Mediated Mechanism Of Damagementioning

confidence: 98%

“…Hyperactivated neutrophils in perivascular infiltration and tissue injury have been described in BS patients (54). These granulocytes have shown increased phagocytosis and superoxide production, potentially contributing to clot formation by fibrinogen oxidation (55). Indeed, it has been recently shown that neutrophil activation promotes fibrinogen oxidation and thrombosis formation in BS.…”

Section: Immunological Etiology Neutrophil Mediated Mechanism Of Damagementioning

confidence: 99%

Pathogenesis of Behçet's Syndrome: Genetic, Environmental and Immunological Factors

et al. 2021

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Behçet's syndrome (BS) is a rare systemic vasculitis, characterized by a wide range of different clinical involvements and unpredictable phases of recurrence and remission. BS can be described as a multifactorial disease with an incompletely known etiopathogenesis; in fact, though presenting some peculiar features, such as its typical geographic distribution and the strong association with the well-known genetic predisposing factor HLA-B*51, the cause behind the onset and progression of the disease remains currently not fully understood. Besides genetic HLA and non-HLA predisposing associations and epigenetic influence, environmental factors also play an important role in the pathogenesis of the disease, and among these, infectious agents (both bacterial and viral) and specific microbiome alterations are considered of particular relevance in BS pathogenesis. BS has been included for decades among autoimmune diseases, in light of evidence showing T- and B-cell aberrant responses. However, because of recurrent mucocutaneous lesions and episodes of inflammation without antigen-specific T-cell or autoantibody responses, BS has also been classified among autoinflammatory disorders. Nevertheless, differently from autoinflammatory diseases, BS mildly responds to therapies targeting IL-1, its onset is not usually in childhood, and has high neutrophilic vasculitic involvement. Finally, given the association with HLA class I alleles, similar to spondyloarthropathies, the concept of BS as a major histocompatibility complex (MHC) I -opathy has been introduced. Understanding the complex etiopathogenesis of BS is essential to identify modifiable risk factors of BS occurrence or exacerbation and to develop targeted therapies. This review summarizes current evidence on the main genetic, environmental and immunological factors contributing to BS development.

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Neutrophil-mediated Thrombosis and NETosis in Behçet's Disease: a Hypothesis

Cited by 13 publications

References 33 publications

Bibliometric and Altmetric Analyses of Publication Activity in the Field of Behcet's Disease in 2010–2019

Bibliometric and Altmetric Analyses of Publication Activity in the Field of Behcet's Disease in 2010–2019

The clinical features, image findings and risk factors of vena cava syndrome in Behçet's syndrome

Pathogenesis of Behçet's Syndrome: Genetic, Environmental and Immunological Factors

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