Neutrophil membrane-mimicking nanodecoys with intrinsic anti-inflammatory properties alleviate sepsis-induced acute liver injury and lethality in a mouse endotoxemia model
“…As shown in Fig. 1 B and C, the plasma levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), which are used as biomarkers for acute liver dysfunction, 13 gradually became elevated over time. Similarly, MDA content, MPO activity, and histological injury in the liver also increased gradually with time, indicating that sepsis could induce lipid peroxidation and neutrophil infiltration during its pathological progression ( Fig.…”
Section: Resultsmentioning
confidence: 99%
“…However, simultaneously exaggerated activation and uncontrolled tissue infiltration of neutrophils cause excess oxidative stress, inflammation, and subsequent tissue injury, 35 thus making them a potential therapeutic target to treat sepsis in our study and others. 13 , 36 However, neutrophil populations in sepsis are not homogenous; therefore, exploring neutrophil heterogeneity will help regulate neutrophils accurately to obtain a balance between protective immunity and tissue injury.…”
Section: Resultsmentioning
confidence: 99%
“…Furthermore, endothelial cell–neutrophil interactions are crucial for neutrophil infiltration to the liver. 13 Notably, ECs-4, the major subcluster of endothelial cells at 24 h after CLP, expressed relatively high levels of chemokines ( Ccl2 and Ccl5 ), cytokines ( Csf3 / G-CSF ), and adhesion molecules ( Sele and Selp ), whereas the corresponding receptors were widely expressed in Neu-3, suggesting that functional interactions between Neu-3 and ECs-4 may play significant roles in enhancing neutrophil infiltration into liver tissues ( Fig. 5 B).…”
“…As shown in Fig. 1 B and C, the plasma levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), which are used as biomarkers for acute liver dysfunction, 13 gradually became elevated over time. Similarly, MDA content, MPO activity, and histological injury in the liver also increased gradually with time, indicating that sepsis could induce lipid peroxidation and neutrophil infiltration during its pathological progression ( Fig.…”
Section: Resultsmentioning
confidence: 99%
“…However, simultaneously exaggerated activation and uncontrolled tissue infiltration of neutrophils cause excess oxidative stress, inflammation, and subsequent tissue injury, 35 thus making them a potential therapeutic target to treat sepsis in our study and others. 13 , 36 However, neutrophil populations in sepsis are not homogenous; therefore, exploring neutrophil heterogeneity will help regulate neutrophils accurately to obtain a balance between protective immunity and tissue injury.…”
Section: Resultsmentioning
confidence: 99%
“…Furthermore, endothelial cell–neutrophil interactions are crucial for neutrophil infiltration to the liver. 13 Notably, ECs-4, the major subcluster of endothelial cells at 24 h after CLP, expressed relatively high levels of chemokines ( Ccl2 and Ccl5 ), cytokines ( Csf3 / G-CSF ), and adhesion molecules ( Sele and Selp ), whereas the corresponding receptors were widely expressed in Neu-3, suggesting that functional interactions between Neu-3 and ECs-4 may play significant roles in enhancing neutrophil infiltration into liver tissues ( Fig. 5 B).…”
“…In a mouse model with sepsis, NM administration showed good biocompatibility and significantly reduced plasma levels of inflammatory cytokines and biomarkers of liver injury, including aspartate aminotransferase, alanine aminotransferase, and direct bilirubin. Therefore, it provides a promising therapeutic strategy for treating acute liver injury caused by sepsis ( 155 ).…”
Cardiovascular disease remains one of the leading causes of death in China, with increasingly serious negative effects on people and society. Despite significant advances in preventing and treating cardiovascular diseases, such as atrial fibrillation/flutter and heart failure over the last few years, much more remains to be done. Therefore, developing innovative methods for identifying and managing cardiovascular disorders is critical. Nanomaterials provide multiple benefits in biomedicine, primarily better catalytic activity, drug loading, targeting, and imaging. Biomimetic materials and nanoparticles are specially combined to synthesize biomimetic nanoparticles that successfully reduce the nanoparticles’ toxicity and immunogenicity while enhancing histocompatibility. Additionally, the biological targeting capability of nanoparticles facilitates the diagnosis and therapy of cardiovascular disease. Nowadays, nanomedicine still faces numerous challenges, which necessitates creating nanoparticles that are highly selective, toxic-free, and better clinically applicable. This study reviews the scientific accomplishments in this field over the past few years covering the classification, applications, and prospects of noble metal biomimetic nanozymes and biomimetic nanocarriers.
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