Neutrophil Phagocytic Function and Humoral Immune Response with Reference to Ascorbate Supplementation in Aging Humans

Jayachandran, Muthuvel; Rani, Packiasamy Juliet Arockia; Arivazhagan, Palaniyappan; Panneerselvam, Chinnakkannu

doi:10.1089/rej.1.2000.3.37

Cited by 19 publications

(22 citation statements)

References 5 publications

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“…Interestingly, multiple studies showed that the effect of vitamin C on phagocytic function of neutrophil is dose dependent. Vitamin C supplement in a dose of 200 mg to 1 g daily for 1–4 months improved neutrophilic phagocytic activity [ 43 , 44 ]. However, administration of 2 g of vitamin C on a daily basis for 2 weeks impaired bacterial killing activity of neutrophil [ 45 ].…”

Section: Immunomodulatory Effect Of Vitamin Cmentioning

confidence: 99%

“…Multiple studies showed that experimentally induced vitamin C deficiency leads to impaired cellular and humoral immune response [ 47 ]. Age-related vitamin C deficiency is associated with low IgG and IgM serum levels [ 43 ]. Evidence showed that vitamin C enhances proliferation, differentiation and maturation of T lymphocytes in vitro [ 48 , 49 ].…”

Section: Immunomodulatory Effect Of Vitamin Cmentioning

confidence: 99%

“…An in vitro evidence showed that vitamin C increased production of immunoglobulins by peripheral blood lymphocytes [ 51 ]. Moreover, vitamin C supplement of 200 mg/day for 1–3 months increased IgG and IgM serum levels and improved humoral immune response in elderly [ 43 ]. An animal study showed that vitamin C inhibited the negative immunoregulatory effect of T regulatory cells, which in turn enhanced T cell-medicated response leading to improvement of sepsis and sepsis-induced multi-organ failure [ 11 ].…”

Section: Immunomodulatory Effect Of Vitamin Cmentioning

confidence: 99%

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Overview of the possible role of vitamin C in management of COVID-19

2020

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The mainstay of management of coronavirus disease 2019 (COVID-19) is mainly supportive as to date there is no effective antiviral treatment, apart from remdesivir which has been approved by Food and Drug administration (FDA) for treatment of COVID-19, or vaccine. Supplementation with micronutrients, such as vitamins and minerals, has gained an increasing interest as part of the supportive management of COVID-19. Vitamin C levels in serum and leukocytes are depleted during the acute stage of infection owing to increased metabolic demands. High-dose vitamin C supplement helps to normalise both serum and leukocytes vitamin C levels. Vitamin C has multiple pharmacological characteristics, antiviral, anti-oxidant, anti-inflammatory and immunomodulatory effects, which make it a potential therapeutic option in management of COVID-19. The use of high dose of intravenous vitamin C for management of COVID-19 in China and the United Stated has shown promising results. There were no reported adverse reactions with the short-term use of high dose of vitamin C. Given the fact that vitamin C is cheap, available and safe drug with beneficial effects in management of viral infections and critically ill patients reported in previous clinical trials, it is sensible to add it to COVID-19 management protocol particularly if the current ongoing clinical trials testing the effect of vitamin C in management of COVID-19 show positive results.

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Section: Immunomodulatory Effect Of Vitamin Cmentioning

confidence: 99%

Section: Immunomodulatory Effect Of Vitamin Cmentioning

confidence: 99%

Section: Immunomodulatory Effect Of Vitamin Cmentioning

confidence: 99%

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Overview of the possible role of vitamin C in management of COVID-19

2020

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“…Intracellular concentrations of vitamin C in human leukocytes have been shown to decline with increasing age, accompanied by neutrophil function impairment. Oral administration of vitamin C resulted in improved neutrophil functions and serum immunoglobulin levels [40] . An earlier investigation showed that administration of 1 g of vitamin C together with 200 mg of vitamin E for 16 weeks to healthy elderly women enhanced neutrophil chemotaxis and phagocytosis, and decreased concentrations in serum lipid peroxides, which is indicative of improved resistance to oxidative stress [41] .…”

Section: Vitamin C and The Immune Systemmentioning

confidence: 99%

Immune-Enhancing Role of Vitamin C and Zinc and Effect on Clinical Conditions

Wintergerst

Maggini

Hornig³

2006

Ann Nutr Metab

355

292

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Vitamin C concentrations in the plasma and leukocytes rapidly decline during infections and stress. Supplementation of vitamin C was found to improve components of the human immune system such as antimicrobial and natural killer cell activities, lymphocyte proliferation, chemotaxis, and delayed-type hypersensitivity. Vitamin C contributes to maintaining the redox integrity of cells and thereby protects them against reactive oxygen species generated during the respiratory burst and in the inflammatory response. Likewise, zinc undernutrition or deficiency was shown to impair cellular mediators of innate immunity such as phagocytosis, natural killer cell activity, and the generation of oxidative burst. Therefore, both nutrients play important roles in immune function and the modulation of host resistance to infectious agents, reducing the risk, severity, and duration of infectious diseases. This is of special importance in populations in which insufficient intake of these nutrients is prevalent. In the developing world, this is the case in low- and middle-income countries, but also in subpopulations in industrialized countries, e.g. in the elderly. A large number of randomized controlled intervention trials with intakes of up to 1 g of vitamin C and up to 30 mg of zinc are available. These trials document that adequate intakes of vitamin C and zinc ameliorate symptoms and shorten the duration of respiratory tract infections including the common cold. Furthermore, vitamin C and zinc reduce the incidence and improve the outcome of pneumonia, malaria, and diarrhea infections, especially in children in developing countries.

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“…4 Our recent studies show that supplementation with ascorbic acid improves neutrophil phagocytic function, humoral immunity, and antioxidants in aging humans. 5,6 Compounds able to restore reduced glutathione are of therapeutic interest to ensure the antioxidative function of glutathione within the cell. One such antioxidant is lipoate, which is an essential cofactor in several mitochondrial dehydrogenase complexes.…”

Section: Introductionmentioning

confidence: 99%

α-Lipoic Acid Enhances Reduced Glutathione, Ascorbic Acid, and α-Tocopherol in Aged Rats

Arivazhagan¹,

Samuel²,

Elango³

et al. 2002

Journal of Anti-Aging Medicine

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It is hypothesized that a reduction in the level of antioxidants with age leads to an impairment in the quenching of free radicals, which in turn increases the risk of succumbing to ageassociated disorders. Male albino rats of Wistar strain (both young and aged rats) were treated with lipoic acid for 7 and 14 days. Analyses were carried out in blood, liver, kidney, and brain for lipid peroxidation, reduced glutathione, ascorbic acid, and a-tocopherol. The levels of reduced glutathione, and vitamins C and E were found to be lowered in aged rats, whereas the level of lipid peroxidation was found to be high. After intraperitoneal administration of lipoate (a thiol antioxidant) to the aged rats, a time-dependent reduction in the level of lipid peroxidation and elevation in the levels of reduced glutathione, and vitamins C and E were observed. From our observations, we conclude that lipoic acid, a dithiol, normalizes lipid peroxidation and prevents the oxidation of reduced glutathione, possibly through recycling mechanisms, thereby maintaining normal metabolic function. Thus, lipoic acid supplementation could be beneficial in minimizing age-associated disorders where free radicals are the major cause. 265

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Neutrophil Phagocytic Function and Humoral Immune Response with Reference to Ascorbate Supplementation in Aging Humans

Cited by 19 publications

References 5 publications

Overview of the possible role of vitamin C in management of COVID-19

Overview of the possible role of vitamin C in management of COVID-19

Immune-Enhancing Role of Vitamin C and Zinc and Effect on Clinical Conditions

α-Lipoic Acid Enhances Reduced Glutathione, Ascorbic Acid, and α-Tocopherol in Aged Rats

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