Neutrophil response of anaerobic jump trained diabetic rats

Souza, Carine Ferreira de; Machado, Andressa Franzoi; Bonatto, Sandro José Ribeiro; Grando, Fernanda Cristine Ceccon; Pessini, Cristina; Alves, Luciana e Sá; Lima, C.D.; Brito, Gleisson Allison Pereira de; Nunes, Everson Araújo; Fernandes, Luíz Cláudio

doi:10.1007/s00421-008-0865-9

Cited by 5 publications

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References 44 publications

(54 reference statements)

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“…These animals exhibit many changes similar to those seen in humans with type 1 DM, such as hyperglycemia, dyslipidemia, and weight loss (8). We investigate here the effect of interval training, using low-volume and highintensity exercise, on blood biochemical and immune parameters in type 1 diabetic rats.…”

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confidence: 99%

Interval training attenuates the metabolic disturbances in type 1 diabetes rat model

Rocha

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Pequito

et al. 2013

Arq Bras Endocrinol Metab

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Objective: This study investigated the effect of interval training on blood biochemistry and immune parameters in type 1 diabetic rats. Materials and methods: Male Wistar rats were divided into four groups: sedentary (SE, n = 15), interval training (IT, n = 17), diabetic sedentary (DSE, n = 17), diabetic interval training (DIT, n = 17). Diabetes was induced by i.v. injection of streptozotocin (60 mg/kg). Swimming Interval Training consisted of 30-s exercise with 30-s rest, for 30 minutes, during 6 weeks, four times a week, with an overload of 15% of body mass. Plasma glucose, lactate, triacylglycerol and total cholesterol concentrations, phagocytic capacity, cationic vesicle content, and superoxide anion and hydrogen peroxide production by blood neutrophils and peritoneal macrophages were evaluated. Proliferation of mesenteric lymphocytes was also estimated. Results: Interval training resulted in attenuation of the resting hyperglycemic state and decreased blood lipids in the DIT group. Diabetes increased the functionality of blood neutrophils and peritoneal macrophages in the DSE group. Interval training increased all functionality parameters of peritoneal macrophages in the IT group. Interval training also led to a twofold increase in the proliferation of mesenteric lymphocytes after 6 weeks of exercise in the DIT group. Conclusion: Low-volume high-intensity physical exercise attenuates hyperglycemia and dislipidemia induced by type 1 diabetes, and induces changes in the functionality of innate and acquired immunity. Arq Bras Endocrinol Metab. 2013;57(8):594-602 Keywords Interval training; diabetes mellitus; immune system; hyperglycemia RESUMO Objetivo: Este estudo investigou os efeitos do treinamento intervalado sobre parâmetros bioquí-micos e imunológicos em ratos diabéticos do tipo 1. Materiais e métodos: Ratos Wistar machos foram divididos em quatro grupos: sedentário (SE, n = 15), treinamento intervalado (TI, n = 17), sedentário diabético (SED, n = 17) e treinamento intervalado diabético (TID, n = 17). O diabetes foi induzido por uma injeção intravenosa de estreptozotocina (60 mg/kg). O treinamento intervalado de natação consistiu de 30s de exercício com 30s de recuperação, 30 minutos, durante 6 semanas, 4 vezes por semana, com sobrecarga de 15% da massa corporal. Foram avaliados glicemia, lactato sanguíneo, concentração de triacilglicerol e colesterol total, capacidade fagocítica, conteúdo de vesí-culas catiô nicas, produção de ânion superóxido e peróxido de hidrogênio por neutrófilos sanguíneos e macrófagos peritoneais. A proliferação de linfócitos mesentéricos também foi avaliada. Resultados: O treinamento intervalado resultou em atenuação do estado hiperglicêmico e diminuiu os lipídeos sanguíneos no grupo TID. O diabetes aumentou a funcionalidade dos neutrófilos sanguíneos e macrófagos peritoneais do grupo SED. O treinamento intervalado aumentou todos os parâmetros funcionais dos macrófagos peritoneais do grupo TI. O treinamento intervalado também aumentou duas vezes a proliferação dos linfóci...

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confidence: 99%

Interval training attenuates the metabolic disturbances in type 1 diabetes rat model

Rocha

Coelho

Pequito

et al. 2013

Arq Bras Endocrinol Metab

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“…Concerning the anaerobic training protocols, many studies have used efforts with jumps performed in water 3,4 and on platform through eletric stimulation 5,6 in different nutritional 7 and pathological conditions 3 . The training protocols with jumps are composed of 3-4 sets of 10-12 jumps with intervals of 60-90s 6,7 .…”

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confidence: 99%

“…The training protocols with jumps are composed of 3-4 sets of 10-12 jumps with intervals of 60-90s 6,7 . Additionally, the intensity increase is performed with weight addition corresponding to the body weight 4 or a maximum repetition 8 . High-intensity physical training performed for short periods of time has significant effects on the anaerobic glycolytic system, in a way that the increase of the ATP production is followed by increase of muscular lactate production 9 .…”

Section: Introductionmentioning

confidence: 99%

Respostas lactacidêmicas de ratos ao treinamento intermitente de alta intensidade

Panveloski-Costa

Papoti

Moreira

et al. 2012

Rev Bras Med Esporte

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During high-intensity intermittent muscle contractions for short periods of time there is an important involvement of glycolytic metabolism and consequent increased blood lactate concentrations. This study aimed to evaluate the blood lactate responses in Wistar rats submitted to high-intensity intermittent training (jump squat) protocol during 6 weeks, 3 sessions, 12 x/session, 60s of interval between sessions. There was significant increase of blood lactate concentrations during the acute bout of high-intensity intermittent exercise (basal blood lactate vs blood lactate after last effort, P<0.001); however, after six weeks of training, there was significant reduction (49%) in blood lactate response to the exercise in comparison to the first session, P=0.0002. The high-intensity intermittent exercise performed at intervals of 60 seconds stimulated the glycolytic system; nevertheless, the training promoted reduction in blood lactate responses to high--intensity intermittent protocol, suggesting hence improvement in phosphocreatine recovery capacity and in mitochondrial biogenesis.

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“…These animals exhibit many changes similar to those seen in humans with DM, such as hyperglycemia and dyslipidemia 10 . Our group have previously shown that, after six weeks of IT, STZ-induced diabetic rats present a significant reduction of glycaemia 11 .…”

Section: Introductionmentioning

confidence: 84%

Interval Training Is Insufficient to Attenuate Metabolic Disturbances in Diabetic Rats

Rocha

Nunes

Venera

et al. 2016

Rev Bras Med Esporte

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Introduction: Type 1 diabetes is a metabolic disease associated to blood disturbances and disorder of the innate immune system functionality. Objective: This study investigated the effect of two weeks interval training on blood biochemistry and immunological parameters in rats with type 1 diabetes. Methods: Male Wistar rats were divided into three groups: sedentary (SE, n = 10), diabetic sedentary (DI, n = 10), diabetic interval training (DIT, n = 10). IV injection of streptozotocin (45 mg/kg) induced diabetes. Interval training consisted of swimming exercise for 30 seconds with 30 seconds of rest for 30 minutes three times a week during two weeks, with an overload of 15% of the total body mass. The evaluations performed were fasting blood glucose, triglycerides, very low-density lipoprotein cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and total cholesterol concentrations, phagocytic capacity, cationic vesicles content, superoxide anion, and production of hydrogen peroxide of blood neutrophils and peritoneal macrophages. Results: The results showed that two weeks interval training did not attenuate the hyperglycemic state at rest and did not decrease blood lipids in the DIT group. Diabetes increased the functionality of blood neutrophils and peritoneal macrophages in the DI group. Interval training increased the content of cationic vesicles and the phagocytic capacity of blood neutrophils and peritoneal macrophages in the DIT group. Conclusion: It was found that two weeks of interval training increased the functionality parameters of innate immune cells, although this has been insufficient to attenuate the biochemical disorders caused by diabetes.

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Neutrophil response of anaerobic jump trained diabetic rats

Cited by 5 publications

References 44 publications

Interval training attenuates the metabolic disturbances in type 1 diabetes rat model

Interval training attenuates the metabolic disturbances in type 1 diabetes rat model

Respostas lactacidêmicas de ratos ao treinamento intermitente de alta intensidade

Interval Training Is Insufficient to Attenuate Metabolic Disturbances in Diabetic Rats

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