Neutrophil rich CD30 Positive Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Report and Review of Literature

Abstract

We describe a case of neutrophil rich variant of primary cutaneous anaplastic large cell lymphoma (PCALCL) and the clinicopathological features of cases reported in the literature. In all cases the male to female ratio is 1.4?:?1. The age at presentation ranges between 12 and 82 years with a mean age of 50.73 years. Various clinical lesions including nodules (47.8?%), tumormasses (34.8?%), plaques (21.7?%) and unusual variants (13.4?%) are noted. 47.8?% of lesions are associated with ulceration. Multifocal lesions are seen in about 18.4?% of cases. Lesions are located in extremities (44.7?%), trunk (36.8?%), head and neck (34.2?%). Around 10.5?% of patients are immunocompromised. About 5.3?% of cases show peripheral neutrophilia. Histopathological examinations show diffuse dermal infiltrate of large anaplastic (53.5?%), pleomorphic (27.9?%) or small to medium sized atypical lymphocytes (18.6?%) in inflammatory background. Subcutaneous tissues are involved in about 43.5?% of biopsies. Some biopsies show epidermal changes as epidermotropism (32.6?%), hyperplasia (20.9?%) or ulceration (7?%). 18.6?% of specimens show necrosis and angiodestruction. We try to increase awareness of this rare variant.