Neutrophil-Rich, Ki-1-Positive Anaplastic Large-Cell Malignant Lymphoma

Mann, Karen P.; Hall, Barbara; Kamino, Hideko; Borowitz, Michael J.; Ratech, Howard

doi:10.1097/00000478-199504000-00002

Cited by 117 publications

(71 citation statements)

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“…In consistent with strong effects of IL-17 on neutrophils, extensive neutrophil infiltration has been observed in some cases of ALCL, as referred to as neutrophil-rich ALCL, which can sometimes be misdiagnosed as an inflammatory disease rather than lymphoma. [45][46][47] Frequent B symptoms in ALCL also might be attributable to this IL-17-producing immunophenotype. In this study, antisense-based miR135b blockade reduced tumor angiogenesis and growth in an in vivo tumor model, which observation is consistent with the proangiogenic function of IL-17 ( Figure 6).…”

Section: Discussionmentioning

confidence: 99%

miR-135b mediates NPM-ALK–driven oncogenicity and renders IL-17–producing immunophenotype to anaplastic large cell lymphoma

Matsuyama

Suzuki

Nishimori

et al. 2011

Blood

168

149

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Many transformed lymphoma cells show immune-phenotypes resembling the corresponding normal lymphocytes; thus, they provide a guide for proper diagnosis and present promising routes to improve their pathophysiologic understanding and to identify novel therapeutic targets. However, the underlying molecular mechanism(s) of these aberrant immunephenotypes is largely unknown. Here, we report that microRNA-135b (miR-135b) mediates nucleophosmin-anaplastic lymphoma kinase (

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Section: Discussionmentioning

confidence: 99%

miR-135b mediates NPM-ALK–driven oncogenicity and renders IL-17–producing immunophenotype to anaplastic large cell lymphoma

Matsuyama

Suzuki

Nishimori

et al. 2011

Blood

168

149

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“…1,[4][5][6][7]18 However, it is not yet clear whether these morphological variants have prognostic implications, although previous reports have suggested that the small-cell variant cases have some distinctive clinical features. Indeed, involvement of peripheral blood is rare in ALCL, whereas the small-cell variant, which represents only 8% (31/410) of ALCL (G Delsol, personal observations, 2003), may be more frequently associated with a leukemic phase.…”

Section: Discussionmentioning

confidence: 99%

“…Although these lymphomas have distinct morphological, phenotypical and cytogenetic features and constitute a well-defined entity, they show a broad spectrum of morphological subtypes including common type, lymphohistiocytic and small cell variants. [3][4][5][6][7][8][9] The small-cell variant is characterized by a predominant population of small cells with only scattered large cells ('hallmark cells'). These latter cells are often concentrated around small blood vessels.…”

Section: Introductionmentioning

confidence: 99%

Establishment of a novel anaplastic large-cell lymphoma-cell line (COST) from a ‘small-cell variant’ of ALCL

et al. 2004

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Anaplastic large-cell lymphoma (ALCL) is a distinct biological and cytogenetic entity with a broad spectrum of morphological features (common type, small-cell variant and lymphohistiocytic variant). Few cell lines of ALCL are available and they all originate from primary tumors demonstrating the common type morphology (ie large-sized lymphoma cells). We established a new ALCL cell line (COST) from the peripheral blood of a patient with a small-cell variant of ALCL, at diagnosis. Cells growing in vitro and in SCID mice consisted of two populations, that is, small-and large-sized cells as seen in the patient's tumor. Both large and small malignant cells were positive for CD43/MT1 T-cell associated antigen, perforin, granzyme B and TIA-1, but negative for CD2, CD3, CD5, CD7, CD4 and CD8 antigens. Standard cytogenetic studies as well as multiplex FISH confirmed the presence of the canonical t(2;5)(p23;q35) translocation, but also revealed additional numerical and structural abnormalities. The COST cell line is the first ALCL small-cell variant cell line, and thus provides a potentially useful tool for further functional and molecular studies that should improve our understanding of the small-cell variant of ALCL, which is more frequently complicated by a leukemic phase.

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“…Plasma cells may be numerous, but eosinophils are infrequent. In most cases polymorphonuclear leukocytes are absent, although rare cases containing abundant neutrophils or eosinophils have been described (34,35).…”

Section: Histologic Featuresmentioning

confidence: 99%

Anaplastic Large Cell Lymphoma: The Shifting Sands of Diagnostic Hematopathology

2001

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Anaplastic large cell lymphoma (ALCL) is a paradigm for the process used to define new disease entities, and provides a model that is applicable to all areas of pathology. ALCL was first recognized based on characteristic histologic features (sinusoidal invasion) and a distinctive immunophenotype (CD30؉). However, neither sinusoidal invasion nor CD30-positivity proved to be entirely specific. Subsequently, a characteristic cytogenetic abnormality was identified, the t(2;5), that led to identification of the genes involved in the translocation (NPM/ALK) and insights into the pathogenesis. Generation of monoclonal antibodies to the aberrantly expressed anaplastic large cell lymphoma kinase (ALK) such as ALK-1 can be used diagnostically, and have led to improved definition of the diagnostic entity with important clinical and prognostic implications. These studies also have clarified the relationship of ALCL to Hodgkin's disease, another lymphoid malignancy associated with CD30 expression. We have learned that the ultimate histologic spectrum of ALCL is both narrower and broader than originally believed. The small cell and lymphohistiocytic variants of ALCL are ALK-positive, and are an accepted part of the disease entity, although the neoplastic cells may appear neither large nor anaplastic. Conversely, most cases of Hodgkin's-like ALCL have proved to be more closely related to true Hodgkin's disease, and are unrelated to ALCL.

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Neutrophil-Rich, Ki-1-Positive Anaplastic Large-Cell Malignant Lymphoma

Cited by 117 publications

References 0 publications

miR-135b mediates NPM-ALK–driven oncogenicity and renders IL-17–producing immunophenotype to anaplastic large cell lymphoma

miR-135b mediates NPM-ALK–driven oncogenicity and renders IL-17–producing immunophenotype to anaplastic large cell lymphoma

Establishment of a novel anaplastic large-cell lymphoma-cell line (COST) from a ‘small-cell variant’ of ALCL

Anaplastic Large Cell Lymphoma: The Shifting Sands of Diagnostic Hematopathology

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