Neutrophil to albumin ratio: a biomarker in non-alcoholic fatty liver disease and with liver fibrosis

Bao, Banghe; Xu, Shuang; Sun, Peng; Zheng, Liduan

doi:10.3389/fnut.2024.1368459

Cited by 2 publications

References 55 publications

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Association between Gamma-glutamyl transpeptidase-to-lymphocyte ratio with hepatic steatosis and liver fibrosis: a nationally representative cross-sectional study from NHANES 2017 to 2020

Xiao,

Jiang,

Liu

et al. 2024

Preprint

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Background: The prediction and tracking of hepatic steatosis progression is of critical importance, yet there is a notable absence of reliable biomarkers. This study was conducted to identify a novel biomarker to enable accurate forecasting of hepatic steatosis and liver fibrosis. Method: The data for this study were derived from the 2017-2020 National Health and Nutrition Examination Survey (NHANES). The multivariate linear regression models were used to investigate the relationship between the Gamma-glutamyl transpeptidase -to-lymphocyte ratio (GLR), controlled attenuation parameters (CAP), and liver stiffness measurements (LSM). The fitted smooth curve and threshold effect analyses were used to address non-linearity. Subgroup analyses were performed based on gender, age, diabetes, hypertension, and smoking. Result: In total, 6481 patients were enrolled in the analysis. In the multivariate linear regression analysis, GLR is positively correlated with hepatic steatosis [CAP, β=0.29, 95% confidence interval (CI) (0.13, 0.44), P=0.0003]. This positive association is stable among all subgroups. An inverse L-shaped relationship between GLR and CAP was observed, with a stronger correlation when GLR<8.276. The correlation between GLR and liver fibrosis remained significantly linear in the multivariate regression analysis. [LSM β=0.03, 95% CI (0.02, 0.05), P<0.0001]. This association was more potent among participants over 50 years old (P for interaction < 0.05). Conclusion: Our investigation revealed an association between GLR, CAP, and LSM. This association suggests that GLR holds predictive potential for assessing hepatic steatosis and liver fibrosis.

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Association between Gamma-glutamyl transpeptidase-to-lymphocyte ratio with hepatic steatosis and liver fibrosis: a nationally representative cross-sectional study from NHANES 2017 to 2020

Xiao,

Jiang,

Liu

et al. 2024

Preprint

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Neutrophil-to-albumin Ratio as a Prognostic Factor in Patients with Acute Ischemic Stroke

Bao,

Zhang,

et al. 2024

CNR

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Background: Neutrophil-To-Albumin Ratio (NAR) is a novel inflammatory biomarker. However, the potential prognostic value of NAR in acute ischemic stroke (AIS) remains unclear. This study aimed to evaluate whether NAR levels correlated with the 3-month modified Rankin scale (mRS) in patients with AIS. Methods: AIS patients were included in this retrospective study. NAR was calculated as the ratio of absolute neutrophil count to serum albumin level. Logistic regression analyses were used to investigate the effect of NAR on 3-month mRS of AIS. The predictive values of NAR, albumin level, and neutrophil count were compared utilizing receiver operating characteristic (ROC) curves. Moreover, subgroup analyses and interaction tests were conducted to evaluate the consistency of NAR’s effect on AIS prognosis. Results: Of the 780 patients included, 403 (51.67%) had a poor clinical outcome (mRS 3-6) at 3 months. NAR was independently correlated to 3-month poor functional outcome after adjusting for confounders (Odds ratios (OR), 9.34; 95% confidence intervals (CI), 1.09 to 80.13; p =0.0417). Subgroup analysis showed a relative effect consistent with the overall population results, and no statistical interactions were found in the subgroups (all p for interaction > 0.05). The ROC curve showed that the prognosis-related cutoff value for NAR was 0.123, with corresponding specificity and sensitivity of 53.55% and 63.94%, respectively. When comparing the predictive power, NAR (0.590; 95%CI 0.549–0.630) exhibited the highest area under the curve (AUC) of ROC compared to neutrophils (0.584; 95%CI 0.543–0.624) and albumin (0.540; 95%CI 0.500–0.581). Conclusion: There is a positive relationship between NAR levels and 3-month poor functional outcomes in AIS patients, supporting the potential of NAR as a readily available and economic serum biomarker for the early identification of AIS prognosis. Further studies are required to validate the prognostic value and clinical utility of the NAR. result: Of those 780 patients, 403 (51.67%) had poor clinical outcome (mRS 3-6) at 3 months. NAR was independently correlated to 3-month poor functional outcome after adjusting for confounders (Odds ratios (OR), 9.34; 95% confidence intervals (CI), 1.09 to 80.13; p=0.0417). Subgroup analysis showed a relative effect consistent with the overall population results, and no statistical interactions were found in the subgroups (all p for interaction &gt; 0.05). The ROC curve demonstrated that the prognosis-related cutoff value of NAR was 0.123, with corresponding specificity and sensitivity of 53.55% and 63.94%. When comparing the predictive power of neutrophils and albumin, NAR (0.590; 95%CI 0.549–0.630) displayed the highest area under the curve (AUC) of ROC compared to neutrophils (0.584; 95%CI 0.543–0.624) and albumin (0.540; 95%CI 0.500–0.581).

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Neutrophil to albumin ratio: a biomarker in non-alcoholic fatty liver disease and with liver fibrosis

Cited by 2 publications

References 55 publications

Association between Gamma-glutamyl transpeptidase-to-lymphocyte ratio with hepatic steatosis and liver fibrosis: a nationally representative cross-sectional study from NHANES 2017 to 2020

Association between Gamma-glutamyl transpeptidase-to-lymphocyte ratio with hepatic steatosis and liver fibrosis: a nationally representative cross-sectional study from NHANES 2017 to 2020

Neutrophil-to-albumin Ratio as a Prognostic Factor in Patients with Acute Ischemic Stroke

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