Neutrophil to C-reactive Protein Ratio (NCR); An Estimating Factor for Intestinal Ischemia Prior to the Surgery of Incarcerated Inguinal Hernia

Eyvaz, Kemal

doi:10.14744/nci.2021.26878

“…NCR was described as a prognostic factor of bowel resection in incarcerated inguinal hernia. A level of 0.45 was the cutoff value for prediction resection of bowel 20 . In another study, NCR and LCR used for prediction the severity of acute appendicitis 21 .…”

Section: Discussionmentioning

confidence: 99%

Relación preoperatoria de neutrófilos a proteína C reactiva como predictor de complicaciones posoperatorias del cáncer de pancreas

Eyvaz,

Dinçer,

Aydemir

et al. 2024

CIRU

0

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Objective: We would like to investigate the prognostic utility of the previously described factors and offer a new parameter called neutrophil-to-C-reactive protein ratio (NCR) as a predictor of post-operative complications of pancreas cancer. Methods: 92 patients underwent pancreaticoduodenectomy for the pancreatic head tumor were enrolled in this study. Receiver operating curve analysis was performed to detect the cutoff values, and logistic regression analyses were performed to identify the independent risk factors of complications. Results: In univariate analysis, complications were observed in lymphocyte-to-C-reactive protein ratio levels below 0.06

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“…NCR was described as a prognostic factor of bowel resection in incarcerated inguinal hernia. A level of 0.45 was the cutoff value for prediction resection of bowel 20 . In another study, NCR and LCR used for prediction the severity of acute appendicitis 21 .…”

Section: Discussionmentioning

confidence: 99%

¿La vía de señalización de sonic hedgehog desempeña un papel en el mecanismo antirreflujo de la vejiga en los niños?

Tokat,

Tan,

GuÓrocak

2024

CIRU

0

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Objective: We would like to investigate the prognostic utility of the previously described factors and offer a new parameter called neutrophil-to-C-reactive protein ratio (NCR) as a predictor of post-operative complications of pancreas cancer. Methods: 92 patients underwent pancreaticoduodenectomy for the pancreatic head tumor were enrolled in this study. Receiver operating curve analysis was performed to detect the cutoff values, and logistic regression analyses were performed to identify the independent risk factors of complications. Results: In univariate analysis, complications were observed in lymphocyte-to-C-reactive protein ratio levels below 0.06

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Diagnostic accuracy of biomarkers to detect acute mesenteric ischaemia in adult patients: a systematic review and meta-analysis

Reintam Blaser,

Starkopf,

Björck

et al. 2023

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Background Acute mesenteric ischaemia (AMI) is a disease with different pathophysiological mechanisms, leading to a life-threatening condition that is difficult to diagnose based solely on clinical signs. Despite widely acknowledged need for biomarkers in diagnosis of AMI, a broad systematic review on all studied biomarkers in different types of AMI is currently lacking. The aim of this study was to estimate the diagnostic accuracy of all potential biomarkers of AMI studied in humans. Methods A systematic literature search in PubMed, The Cochrane Library, Web of Science and Scopus was conducted in December 2022. Studies assessing potential biomarkers of AMI in (at least 10) adult patients and reporting their diagnostic accuracy were included. Meta-analyses of biomarkers’ sensitivity, specificity, and positive and negative likelihood ratios were conducted. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed, and the study quality was assessed with the QUADAS-2 tool. Results Seventy-five studies including a total of 9914 patients assessed 18 different biomarkers in serum/plasma and one in urine (each reported in at least two studies), which were included in meta-analyses. None of the biomarkers reached a conclusive level for accurate prediction. The best predictive value overall (all studies with any type and stage of AMI pooled) was observed for Ischaemia-modified albumin (2 studies, sensitivity 94.7 and specificity 90.5), interleukin-6 (n = 4, 96.3 and 82.6), procalcitonin (n = 6, 80.1 and 86.7), and intestinal fatty acid-binding protein (I-FABP) measured in serum (n = 16, 73.9 and 90.5) or in urine (n = 4, 87.9 and 78.9). In assessment of transmural mesenteric ischaemia, urinary I-FABP (n = 2, 92.3 and 85.2) and D-dimer (n = 3, 87.6 and 83.6) showed moderate predictive value. Overall risk of bias was high, mainly because of selected study populations and unclear timings of the biomarker measurements after onset of symptoms. Combinations of biomarkers were rarely studied, not allowing meta-analyses. Conclusions None of the studied biomarkers had sufficient sensitivity and specificity to diagnose AMI, although some biomarkers showed moderate predictive accuracy. Future studies should focus on timing of measurements of biomarkers, distinguishing between early stage and transmural necrosis, and between different types of AMI. Additionally, studies on combinations of biomarkers are warranted. PROSPERO registration: CRD42022379341.

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Neutrophil to C-reactive Protein Ratio (NCR); An Estimating Factor for Intestinal Ischemia Prior to the Surgery of Incarcerated Inguinal Hernia

Cited by 4 publications

References 28 publications

Relación preoperatoria de neutrófilos a proteína C reactiva como predictor de complicaciones posoperatorias del cáncer de pancreas

Relación preoperatoria de neutrófilos a proteína C reactiva como predictor de complicaciones posoperatorias del cáncer de pancreas

¿La vía de señalización de sonic hedgehog desempeña un papel en el mecanismo antirreflujo de la vejiga en los niños?

Diagnostic accuracy of biomarkers to detect acute mesenteric ischaemia in adult patients: a systematic review and meta-analysis

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